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公开(公告)号：US20100222331A1
公开(公告)日：2010-09-02
申请号：US12664162
申请日：2008-06-09
申请人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
发明人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
IPC分类号： A61K31/551 , C07D403/04 , A61K31/517 , C07D413/14 , A61K31/536 , C07D403/14 , A61K31/4184 , A61K31/5377 , C07D417/14 , A61K31/5415 , A61P29/00 , A61P31/00 , A61P37/00 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2，R 3，Q，W，X，Y和Z如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 其用途是制备具有上述性质的药物。
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公开(公告)号：US08207179B2
公开(公告)日：2012-06-26
申请号：US12664162
申请日：2008-06-09
申请人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
发明人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
IPC分类号： A61K31/517
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2，R 3，Q，W，X，Y和Z如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 其用途是制备具有上述性质的药物。
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公开(公告)号：US07521457B2
公开(公告)日：2009-04-21
申请号：US11206703
申请日：2005-08-17
申请人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
发明人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
IPC分类号： C07D239/42 , C07D239/46 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，W，X，Y，Z，Ra，Rb，Rc，R 1和R 3如权利要求1中所定义，其适用于治疗以过量 或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。
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4.发明授权公开(公告)号：US07569561B2
公开(公告)日：2009-08-04
申请号：US11675936
申请日：2007-02-16
申请人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Juergen Quant , Flavio Solca , Martin Steegmaier , Stephan Karl Zahn
发明人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Juergen Quant , Flavio Solca , Martin Steegmaier , Stephan Karl Zahn
IPC分类号： C07D403/12 , C07D413/12 , C07D498/04 , C07D487/04 , A61K31/551 , A61K31/553 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D498/04 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, as well as the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 6，X和Y如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，以及其用于制备 具有上述性质的药物组合物。
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5.发明申请INDOLINE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER 审中-公开吲哚衍生物及其在治疗疾病如癌症中的应用公开(公告)号：US20100184747A1
公开(公告)日：2010-07-22
申请号：US12663876
申请日：2008-06-09
申请人： Matthias Treu , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Jens Juergen Quant , Stephan Karl Zahn
发明人： Matthias Treu , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Jens Juergen Quant , Stephan Karl Zahn
IPC分类号： A61K31/551 , A61P35/04 , A61P31/00 , A61P29/00 , C07D403/12 , A61K31/4184 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/497 , C07D413/14 , A61K31/5377
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 4如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物组合物的药物组合物， 上述属性。
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6.发明授权Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权二氢蝶啶酮，其制备方法及其作为药物组合物的用途公开(公告)号：US06861422B2
公开(公告)日：2005-03-01
申请号：US10374876
申请日：2003-02-26
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D295/073 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途 作为药物组合物。
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7.发明授权Dihydropteridione derivatives, process for their manufacture and their use as medicament 有权二氢丙啶衍生物，其制备方法及其作为药物的用途公开(公告)号：US07414053B2
公开(公告)日：2008-08-19
申请号：US11210379
申请日：2005-08-24
IPC分类号： A61K31/5355 , A61K31/5025 , A61K31/4985 , C07D413/14 , C07D487/04 , C07D475/00 , C07D265/30 , C07D295/135 , C07D295/30 , C07D241/12 , A61P35/00
CPC分类号： C07D295/155 , C07D487/04 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译： 公开了式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4， ＆lt;＆gt;和＆lt; 5＆gt;具有本文提供的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物组合物的用途。
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8.发明申请Intermediate Compounds for making Dihydropteridinones Useful as Pharmaceutical Compositions 有权用作制备二氢蝶呤的中间体化合物可用作药物组合物公开(公告)号：US20080171747A1
公开(公告)日：2008-07-17
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。
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9.发明申请New dihydropteridione derivatives, process for their manufacture and their use as medicament 有权新的二氢二萜衍生物，其制备方法及其作为药物的用途公开(公告)号：US20060046989A1
公开(公告)日：2006-03-02
申请号：US11210379
申请日：2005-08-24
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/155 , C07D487/04 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译： 公开了式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4， ＆lt;＆gt;和＆lt; 5＆gt;具有本文提供的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物组合物的用途。
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公开(公告)号：US08003786B2
公开(公告)日：2011-08-23
申请号：US12873687
申请日：2010-09-01
申请人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
发明人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
IPC分类号： C07D475/00
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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