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公开(公告)号：US08796216B2
公开(公告)日：2014-08-05
申请号：US12969810
申请日：2010-12-16
申请人： Stephen Johnstone , Philip Marks , Keith Foster
发明人： Stephen Johnstone , Philip Marks , Keith Foster
CPC分类号： C12N9/52 , A61K38/00 , C07K2319/035 , C07K2319/06 , C12P21/06
摘要： The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumor cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptor a melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalized and inhibits secretion from said tumor cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
摘要翻译： 本发明涉及抑制神经内分泌疾病的方法。 该疗法使用非细胞毒性蛋白酶，其优选靶向神经内分泌肿瘤细胞，优选通过生长抑素或皮质抑素受体，GHRH受体，生长素释放肽受体，铃蟾肽受体，泌尿生素受体，黑色素浓缩激素受体1 ; KiSS-1受体或催乳素释放肽受体。 当这样传递时，蛋白酶被内化并且抑制来自所述肿瘤细胞的分泌。 本发明还涉及用于所述方法的多肽和核酸。
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公开(公告)号：US20110160135A1
公开(公告)日：2011-06-30
申请号：US12969810
申请日：2010-12-16
申请人： Stephen JOHNSTONE , Philip MARKS , Keith FOSTER
发明人： Stephen JOHNSTONE , Philip MARKS , Keith FOSTER
CPC分类号： C12N9/52 , A61K38/00 , C07K2319/035 , C07K2319/06 , C12P21/06
摘要： The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptor a melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalised and inhibits secretion from said tumour cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
摘要翻译： 本发明涉及抑制神经内分泌疾病的方法。 该疗法使用非细胞毒性蛋白酶，其优选靶向神经内分泌肿瘤细胞，优选通过生长抑素或皮质抑素受体，GHRH受体，生长素释放肽受体，铃蟾肽受体，泌尿生素受体，黑色素浓缩激素受体1 ; KiSS-1受体或催乳素释放肽受体。 当这样传递时，蛋白酶被内化并且抑制来自所述肿瘤细胞的分泌。 本发明还涉及用于所述方法的多肽和核酸。
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3.发明授权公开(公告)号：US07843977B2
公开(公告)日：2010-11-30
申请号：US12142114
申请日：2008-06-19
IPC分类号： H01S3/10
CPC分类号： H01S5/0687 , H01S5/005 , H01S5/06837 , H01S5/4025
摘要： A light source and the method for operating the same are disclosed. The light source includes first and second lasers, and first and second wavelength control assemblies. The lasers emit first and second light beams, respectively, at wavelengths that are determined by first and second wavelength control signals. First and second beam splitters split the first and second light beams, respectively, to create first and second sampling light beams. The first and second wavelength control assemblies receive sampling light beams and generate the first and second wavelength control signals such that the wavelengths of the first and second light beams differ by no more than a predetermined amount. The first and second wavelength control assemblies each include an absorption cell having a gas that has an optical absorption that varies with the wavelength of the first and second sampling light beams at wavelengths around the output wavelength of the light source.
摘要翻译： 公开了一种光源及其操作方法。 光源包括第一和第二激光器以及第一和第二波长控制组件。 激光器分别以由第一和第二波长控制信号确定的波长发射第一和第二光束。 第一和第二分束器分别分开第一和第二光束以产生第一和第二采样光束。 第一和第二波长控制组件接收采样光束并产生第一和第二波长控制信号，使得第一和第二光束的波长不同于预定量。 第一和第二波长控制组件各自包括具有气体的吸收单元，该气体具有随着在光源的输出波长附近的波长的第一和第二取样光束的波长而变化的光学吸收。
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4.发明申请Light Source That Utilizes Small Footprint Reference Gas Cells for Multiple Laser Frequency Stabilization 有权利用小型脚印参考气体细胞进行多激光频率稳定的光源公开(公告)号：US20090316740A1
公开(公告)日：2009-12-24
申请号：US12142114
申请日：2008-06-19
CPC分类号： H01S5/0687 , H01S5/005 , H01S5/06837 , H01S5/4025
摘要： A light source and the method for operating the same are disclosed. The light source includes first and second lasers, and first and second wavelength control assemblies. The lasers emit first and second light beams, respectively, at wavelengths that are determined by first and second wavelength control signals. First and second beam splitters split the first and second light beams, respectively, to create first and second sampling light beams. The first and second wavelength control assemblies receive sampling light beams and generate the first and second wavelength control signals such that the wavelengths of the first and second light beams differ by no more than a predetermined amount. The first and second wavelength control assemblies each include an absorption cell having a gas that has an optical absorption that varies with the wavelength of the first and second sampling light beams at wavelengths around the output wavelength of the light source.
摘要翻译： 公开了一种光源及其操作方法。 光源包括第一和第二激光器以及第一和第二波长控制组件。 激光器分别以由第一和第二波长控制信号确定的波长发射第一和第二光束。 第一和第二分束器分别分开第一和第二光束以产生第一和第二采样光束。 第一和第二波长控制组件接收采样光束并产生第一和第二波长控制信号，使得第一和第二光束的波长不同于预定量。 第一和第二波长控制组件各自包括具有气体的吸收单元，该气体具有随着在光源的输出波长附近的波长的第一和第二取样光束的波长而变化的光学吸收。
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公开(公告)号：US07440113B2
公开(公告)日：2008-10-21
申请号：US11316855
申请日：2005-12-23
申请人： William R Trutna, Jr. , Geraint Owen , Alan B Ray , James Prince , Eric Stephen Johnstone , Miao Zhu , Leonard S Cutler
发明人： William R Trutna, Jr. , Geraint Owen , Alan B Ray , James Prince , Eric Stephen Johnstone , Miao Zhu , Leonard S Cutler
摘要： An apparatus and method for measuring displacement includes a light beam directed to an interferometer core that splits the light beam into first and second component beams. The first component beam is directed to a diffraction grating at approximately a Littrow angle. A diffraction is received by the interferometer core and is combined with the second component beam. The combination of the first and second component beams is measured to determine displacement of the diffraction grating.
摘要翻译： 用于测量位移的装置和方法包括指向干涉仪芯的光束，其将光束分成第一和第二分量光束。 第一分量光束以大约Littrow角度被引导到衍射光栅。 衍射由干涉仪芯接收并与第二分量光束组合。 测量第一和第二分量光束的组合以确定衍射光栅的位移。
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公开(公告)号：US20080226693A1
公开(公告)日：2008-09-18
申请号：US11685832
申请日：2007-03-14
CPC分类号： B05D1/26 , A61F2/82 , A61F2250/0067 , B05D1/002
摘要： The apparatus and method for preparing a polymeric structure from which a number of medical devices may be constructed is described. The structures are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a stage and converted into a structure. The solvent is evaporated from the structure. The dried solution forms a structure that is removed from the stage and further dried before being stored in an inert environment. Thereafter, a medical device such as a stent may be constructed from the structure.
摘要翻译： 本发明描述了可构建多个医疗装置的聚合物结构的制备装置和方法。 该结构优选由使用低温制造方法的生物可吸收材料形成，由此将药物或其它生物活性剂并入装置中或装置上，并且在加工过程中药物或其它试剂的降解最小化。 该方法包括制备至少一种生物可吸收聚合物和溶剂的溶液。 然后将溶液沉积在载物台上并转化为结构。 溶剂从结构中蒸发掉。 干燥的溶液形成从载体中除去并在储存在惰性环境中之前进一步干燥的结构。 此后，可以从该结构构造诸如支架的医疗装置。
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公开(公告)号：US20110171191A1
公开(公告)日：2011-07-14
申请号：US12996643
申请日：2009-06-11
申请人： Stephen Johnstone , Philip Marks , Keith Foster
发明人： Stephen Johnstone , Philip Marks , Keith Foster
IPC分类号： A61K38/48 , C12N9/96 , C07H21/00 , A61K31/7088 , A61P35/00 , A61P35/04 , A61P3/00 , A61P9/12 , A61P1/12 , A61P1/00
CPC分类号： C12N9/6489 , A61K38/4893 , A61K47/6415 , C07K2319/035 , C07K2319/06
摘要： The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptora melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalised and inhibits secretion—from said tumourcell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
摘要翻译： 本发明涉及抑制神经内分泌疾病的方法。 该疗法使用非细胞毒性蛋白酶，其优选通过生长抑素或皮质抑素受体，GHRH受体，生长素释放肽受体，铃蟾肽受体，泌尿生长因受体α黑素浓缩激素受体1靶向神经内分泌肿瘤细胞; KiSS-1受体或催乳素释放肽受体。 当这样传递时，蛋白酶被内化并且抑制分泌 - 从所述的肿瘤。 本发明还涉及用于所述方法的多肽和核酸。
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8.发明授权公开(公告)号：US07330272B2
公开(公告)日：2008-02-12
申请号：US11119220
申请日：2005-04-29
CPC分类号： G01B9/02018 , G01B9/02051 , G01B9/02058 , G01B2290/70
摘要： At least two discrete quarter wave plates are provided for use as plane mirrors or reflectors in a displacement measuring interferometer, where the plates share common or substantially common reflecting surface geometries. A plurality of geometrically matched discrete matched quarter wave plates reduces the amount of tilt between an input beam provided to, and an output measurement beam provided by, an interferometer, resulting in increased interferometer dynamic range.
摘要翻译： 提供至少两个离散四分之一波片，用作位移测量干涉仪中的平面镜或反射器，其中板共享共同的或基本上共同的反射表面几何形状。 多个几何匹配的离散匹配的四分之一波片减少了提供给干涉仪提供的输入波束和由干涉仪提供的输出测量波束之间的倾斜量，导致增加的干涉仪动态范围。
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