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10 条记录 (耗时 0.019 秒)

    Sugar base surfactant for nanocrystals
    1.
    发明授权
    Sugar base surfactant for nanocrystals 失效
    用于纳米晶体的糖基表面活性剂

    公开(公告)号：US5622938A

    公开(公告)日：1997-04-22

    申请号：US444796

    申请日：1995-05-19

    申请人： Sui-Ming Wong

    发明人： Sui-Ming Wong

    IPC分类号： A61K9/107 ,  A61K9/14 ,  A61K9/18 ,  A61K47/06 ,  A61K49/04 ,  B82B1/00 ,  A01N43/04 ,  A61K31/70

    CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K9/145

    摘要： Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier having the formula: ##STR1## wherein R is phenyl-(CH.sub.2).sub.10 CO or C.sub.12 H.sub.25 NHCO adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

    摘要翻译： 基本上由具有下式的表面改性剂的结晶药物组成的分散性颗粒：其中R是以足以维持有效平均值的量吸附在其表面上的苯基 - （CH2）10CO或C12H25NHCO 粒径小于约400nm，制备这种颗粒的方法和含有颗粒的分散体。 含有该颗粒的药物组合物表现出意想不到的生物利用度，并且可用于治疗哺乳动物的方法。

    Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin
    6.
    发明授权
    Dual purposed diagnostic/therapeutic agent having a tri-iodinated benzoyl group linked to a coumarin 失效
    具有与香豆素连接的三碘化苯甲酰基的双重目的诊断/治疗剂

    公开(公告)号：US5665330A

    公开(公告)日：1997-09-09

    申请号：US385502

    申请日：1995-02-08

    申请人： Sui-Ming Wong

    发明人： Sui-Ming Wong

    IPC分类号： A61K49/04 ,  C07D311/16 ,  A01N43/16 ,  C07D311/78

    CPC分类号： A61K49/0433 ,  C07D311/16

    摘要： The invention provides a novel compound having the structure ##STR1## wherein R is alkyl and R1, R2, R3 and R4 are each independently OCH3, H or I and n is 0 or 1 and m is 0 or 1.The compound is useful in a method of treating mammals either therapeutically or imaging mammals for diagnostic purposes. Useful therapeutic areas are in treating lymph nodes and tumors and diagnostic treatment is applicable to lymph nodes, tumors and in blood pool imaging. It is particularly advantageous to link an insoluble carrier molecule with a therapeutic or imaging agent to form the structure above. This makes the conjugate insoluble and thus amenable to forming nanoparticles.

    摘要翻译： 本发明提供了具有结构的新化合物，其中R是烷基，R 1，R 2，R 3和R 4各自独立地是OCH 3，H或I，n是0或1，m是0或1.该化合物可用于 用于诊断目的的哺乳动物治疗或成像哺乳动物的方法。 有用的治疗领域是治疗淋巴结和肿瘤，诊断治疗适用于淋巴结，肿瘤和血液池成像。 将不溶性载体分子与治疗剂或成像剂连接以形成上述结构是特别有利的。 这使得共轭物不溶，因此适于形成纳米颗粒。

    Pharmaceutical compositions containing polyalkylene block copolymers which gel at physiological temperature
    9.
    发明授权
    Pharmaceutical compositions containing polyalkylene block copolymers which gel at physiological temperature 失效
    含有在生理温度下凝胶化的聚亚烷基嵌段共聚物的药物组合物

    公开(公告)号：US5705194A

    公开(公告)日：1998-01-06

    申请号：US727863

    申请日：1996-10-08

    申请人： Sui-Ming Wong ,  Eugene R. Cooper ,  Shuqian Xu

    发明人： Sui-Ming Wong ,  Eugene R. Cooper ,  Shuqian Xu

    IPC分类号： A61K9/16 ,  A61K9/14 ,  A61K9/18 ,  A61K31/535 ,  A61K47/34 ,  A61K51/00 ,  A61K7/06 ,  A61K7/135

    CPC分类号： A61K9/146 ,  Y10S514/975 ,  Y10S977/745 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/788 ,  Y10S977/927

    摘要： There is disclosed a pharmaceutical composition which gels at physiological temperature. The composition is comprised of a block copolymer containing one or more polyoxyethylene blocks and one or more polyoxy (higher alkylene) blocks wherein at least some of the blocks are linked together by a linking group characterised in that the linking group is an oxymethylene group, and a therapeutic agent. The therapeutic agent is present as (i) nanoparticles of the therapeutic agent having the block copolymer adsorbed on the surface thereof, (ii) a suspension in a solution of the block copolymer, or (iii) as an aqueous solution in a solution of the block copolymer.

    摘要翻译： 公开了一种在生理温度下凝胶化的药物组合物。 组合物由含有一个或多个聚氧乙烯嵌段和一个或多个聚氧化（高级亚烷基）嵌段的嵌段共聚物组成，其中至少一些嵌段通过连接基团连接在一起，其特征在于连接基团是甲醛基，和 治疗剂。 存在治疗剂为（i）具有吸附在其表面上的嵌段共聚物的治疗剂的纳米颗粒，（ii）嵌段共聚物溶液中的悬浮液，或（iii）作为水溶液在 嵌段共聚物。