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1.发明申请CRYSTAL STRUCTURE OF CMY-10, A BETA-LACTAMASE CAUSING ANTIBIOTIC RESISTANCE WITH EXTENDED-SUBSTRATE SPECTRUM 有权CMY-10的晶体结构，具有延伸基底光谱的抗生素耐药性的BETA-LACTAMASE公开(公告)号：US20090061421A1
公开(公告)日：2009-03-05
申请号：US11659244
申请日：2005-07-25
申请人： Sang Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
发明人： Sang Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
CPC分类号： C12Q1/18 , C07K2299/00 , C12N9/86 , C12Q1/34 , C12Y305/02006 , G01N2333/986 , G01N2500/00
摘要： The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmidic class C β-lactamases having extended-substrate specificity.
摘要翻译： 本发明涉及一种结晶CMY-10的方法，该方法是具有延伸底物光谱的β-内酰胺酶，CMY-10的晶体和CMY-10的晶体结构。 利用本发明提供的CMY-10蛋白质的三维结构，可以开发新的抗生素或抑制剂，其可以防止具有延伸底物特异性的质粒C型β-内酰胺酶出现抗性细菌的出现。
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2.发明授权Hydrogenases isolated from Thermococcus SPP., genes encoding the same, and methods for producing hydrogen using microorganisms having the genes 有权从Thermococcus SPP分离的氢化酶，编码它们的基因，以及使用具有该基因的微生物产生氢的方法公开(公告)号：US08597926B2
公开(公告)日：2013-12-03
申请号：US12746090
申请日：2009-09-07
申请人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
发明人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
IPC分类号： C12N9/02
CPC分类号： C12N9/0006 , C12N9/0067 , C12P3/00 , C12R1/01 , Y02P20/132 , Y02P20/52
摘要： The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.
摘要翻译： 本发明涉及从属于Thermococcus spp的新型超嗜热菌株分离的新型氢化酶，编码氢化酶的基因，以及使用具有该基因的菌株产生氢的方法。 根据本发明的氢生产方法，仅通过在特定培养条件下培养菌株可以产生大量的氢。 因此，本发明的方法的优点在于它们比现有的氢气生产方法更经济和有效，并且即使在高温下也可以产生氢。
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3.发明授权Method for Identifying an inhibitor of plasmidic classic C beta-lactamase having extended-substrate specifity 有权用于鉴定具有延伸底物特异性的质粒C型β-内酰胺酶抑制剂的方法公开(公告)号：US07919267B2
公开(公告)日：2011-04-05
申请号：US12695810
申请日：2010-01-28
申请人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
发明人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
CPC分类号： C12Q1/18 , C07K2299/00 , C12N9/86 , C12Q1/34 , C12Y305/02006 , G01N2333/986 , G01N2500/00
摘要： The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmidic class C β-lactamases having extended-substrate specificity.
摘要翻译： 本发明涉及一种结晶CMY-10的方法，其中CMY-10是具有延伸底物光谱的一种β-内酰胺酶，CMY-10的晶体和CMY-10的晶体结构。 利用本发明提供的CMY-10蛋白质的三维结构，可以开发新颖的抗生素或抑制剂，其可以防止出现具有延伸底物特异性的质粒类C＆bgr-内酰胺酶出现的抗性细菌。
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4.发明申请CRYSTAL STRUCTURE OF CMY-10, A BETA-LACTAMASE CAUSING ANTIBIOTIC RESISTANCE WITH EXTENDED-SUBSTRATE SPECTRUM 有权CMY-10的晶体结构，具有延伸基底光谱的抗生素耐药性的BETA-LACTAMASE公开(公告)号：US20110008800A1
公开(公告)日：2011-01-13
申请号：US12695810
申请日：2010-01-28
申请人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
发明人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
IPC分类号： G01N33/53
CPC分类号： C12Q1/18 , C07K2299/00 , C12N9/86 , C12Q1/34 , C12Y305/02006 , G01N2333/986 , G01N2500/00
摘要： The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmatic class C β-lactamases having extended-substrate specificity.
摘要翻译： 本发明涉及一种结晶CMY-10的方法，其中CMY-10是具有延伸底物光谱的一种β-内酰胺酶，CMY-10的晶体和CMY-10的晶体结构。 利用本发明提供的CMY-10蛋白质的三维结构，可以开发新的抗生素或抑制剂，其可以防止出现具有延长底物特异性的血浆C＆Bgr-内酰胺酶出现的抗性细菌。
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5.发明申请Novel Hydrogenases Isolated from Thermococcus SPP., Genes Encoding the Same, and Methods for Producing Hydrogen Using Microorganisms Having the Genes 有权从热球菌SPP分离的新型氢化酶，其编码基因以及使用具有基因的微生物产生氢的方法公开(公告)号：US20100311142A1
公开(公告)日：2010-12-09
申请号：US12746090
申请日：2009-09-07
申请人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
发明人： Jung Hyun Lee , Sung Gyun Kang , Hyun Sook Lee , Sang Jin Kim , Kae Kyoung Kwon , Sun Shin Cha , Jung Ho Jeon , Yona Cho , Yun Jae Kim , Seung Seop Bae , Jae Kyu Lim , In Soon Jeong
CPC分类号： C12N9/0006 , C12N9/0067 , C12P3/00 , C12R1/01 , Y02P20/132 , Y02P20/52
摘要： The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.
摘要翻译： 本发明涉及从属于Thermococcus spp的新型超嗜热菌株分离的新型氢化酶，编码氢化酶的基因，以及使用具有该基因的菌株产生氢的方法。 根据本发明的氢生产方法，仅通过在特定培养条件下培养菌株可以产生大量的氢。 因此，本发明的方法的优点在于它们比现有的氢气生产方法更经济和有效，并且即使在高温下也可以产生氢。
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6.发明授权Crystal structure of CMY-10, a β-lactamase causing antibiotic resistance with extended-substrate spectrum 有权CMY-10的晶体结构，具有延长底物光谱的抗生素抗性的β-内酰胺酶公开(公告)号：US07709237B2
公开(公告)日：2010-05-04
申请号：US11659244
申请日：2005-07-25
申请人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
发明人： Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
CPC分类号： C12Q1/18 , C07K2299/00 , C12N9/86 , C12Q1/34 , C12Y305/02006 , G01N2333/986 , G01N2500/00
摘要： The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmidic class C β-lactamases having extended-substrate specificity.
摘要翻译： 本发明涉及一种结晶CMY-10的方法，其中CMY-10是具有延伸底物光谱的一种β-内酰胺酶，CMY-10的晶体和CMY-10的晶体结构。 利用本发明提供的CMY-10蛋白质的三维结构，可以开发新颖的抗生素或抑制剂，其可以防止出现具有延伸底物特异性的质粒类C＆bgr-内酰胺酶出现的抗性细菌。
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