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    DNP63A gene and screening methods of anticancer agent by using it
    1.
    发明授权
    DNP63A gene and screening methods of anticancer agent by using it 有权
    DNP63A基因和抗癌剂的筛选方法

    公开(公告)号：US08232070B2

    公开(公告)日：2012-07-31

    申请号：US12532267

    申请日：2007-03-30

    申请人： Hyun Sook Lee ,  Jung Hwa Lee

    发明人： Hyun Sook Lee ,  Jung Hwa Lee

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N2333/4748

    摘要： This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.

    摘要翻译： 本发明涉及一种编码“Dgr;Np63α”的基因及其抗癌药的筛选方法，更具体地说，一种编码“Dgr;Np63α”的基因和通过与上皮细胞中的潜在抗癌药物接触从细胞核转运至细胞质的蛋白质 癌，包含所述基因和报告基因的重组载体，以及包含所述载体的癌细胞。 此外，本发明涉及抗癌药物的高通量筛选方法，包括通过与癌细胞中的潜在抗癌药物接触来鉴定从细胞核到细胞质的转运和转运Np63α蛋白。

    Apparatus and method for recognizing biological named entity from biological literature based on UMLS
    6.
    发明申请
    Apparatus and method for recognizing biological named entity from biological literature based on UMLS 失效
    基于UMLS的生物文献识别生物命名实体的装置和方法

    公开(公告)号：US20050091081A1

    公开(公告)日：2005-04-28

    申请号：US10777072

    申请日：2004-02-13

    申请人： Soo Jun Park ,  Tae Hyun Kim ,  Hyun Sook Lee ,  Hyun Chul Jang ,  Seon Hee Park

    发明人： Soo Jun Park ,  Tae Hyun Kim ,  Hyun Sook Lee ,  Hyun Chul Jang ,  Seon Hee Park

    IPC分类号： G06F17/20 ,  G06Q50/00 ,  G06F17/60

    CPC分类号： G06Q50/22 ,  G06F19/00 ,  Y10S707/99933 ,  Y10S707/99943

    摘要： The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities. In the present invention, the biological named entities can be effectively extracted which can be used as important information individual in input literature.

    摘要翻译： 本发明涉及一种基于联合医学语言系统（UMLS）从生物文献识别生物命名实体的装置和方法。 该装置和方法从UMLS接收metathesaurus，构建一个概念名称数据库，一个单一名称数据库和一个类别keyterm数据库，它们是用于识别命名实体的语言资源，接收存储在概念名称数据库中的每个概念名称， 通过使用存储在单个名称数据库和类别keyterm数据库中的数据来提取每个概念名称的特征，通过创建用于识别命名实体的规则并通过使用提取的特征来过滤规则来构建规则数据库，接收生物文献 提取作为候选名称实体的名词和名词短语，将存储在规则数据库中的规则应用于名词和名词短语，并识别命名实体。 在本发明中，可以有效地提取生物名称的实体，其可以用作输入文献中个体的重要信息。

    Apparatus and method for recognizing biological named entity from biological literature based on UMLS
    9.
    发明授权
    Apparatus and method for recognizing biological named entity from biological literature based on UMLS 失效
    基于UMLS的生物文献识别生物命名实体的装置和方法

    公开(公告)号：US07403891B2

    公开(公告)日：2008-07-22

    申请号：US10777072

    申请日：2004-02-13

    申请人： Soo Jun Park ,  Tae Hyun Kim ,  Hyun Sook Lee ,  Hyun Chul Jang ,  Seon Hee Park

    发明人： Soo Jun Park ,  Tae Hyun Kim ,  Hyun Sook Lee ,  Hyun Chul Jang ,  Seon Hee Park

    IPC分类号： G06F17/27 ,  G06F17/21 ,  G06F7/00 ,  G06F17/30 ,  G10L15/00

    CPC分类号： G06Q50/22 ,  G06F19/00 ,  Y10S707/99933 ,  Y10S707/99943

    摘要： The present invention relates to an apparatus and method for recognizing biological named entity from biological literature based on united medical language system (UMLS). The apparatus and the method receives metathesaurus from the UMLS, constructs a concept name database, a single name database and a category keyterm database, which are language resources to be used recognize a named entity, receives each concept name stored in the concept name database, extracts features of each of the concept names by using data stored in the single name database and the category keyterm database, constructs a rule database by creating rules used to recognize the named entity and filtering the rules by using the extracted features, receives a biological literature, extracts nouns and noun phrases that are candidate named entities, applies the rules stored in the rule database to the nouns and the noun phrases, and recognizes the named entities. In the present invention, the biological named entities can be effectively extracted which can be used as important information individual in input literature.

    摘要翻译： 本发明涉及一种基于联合医学语言系统（UMLS）从生物文献识别生物命名实体的装置和方法。 该装置和方法从UMLS接收metathesaurus，构建一个概念名称数据库，一个单一名称数据库和一个类别keyterm数据库，它们是用于识别命名实体的语言资源，接收存储在概念名称数据库中的每个概念名称， 通过使用存储在单个名称数据库和类别keyterm数据库中的数据来提取每个概念名称的特征，通过创建用于识别命名实体的规则并通过使用提取的特征来过滤规则来构建规则数据库，接收生物文献 提取作为候选名称实体的名词和名词短语，将存储在规则数据库中的规则应用于名词和名词短语，并识别命名实体。 在本发明中，可以有效地提取生物名称的实体，其可以用作输入文献中个体的重要信息。