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公开(公告)号:US06610329B2
公开(公告)日:2003-08-26
申请号:US09862013
申请日:2001-05-21
IPC分类号: A61K914
CPC分类号: A61K9/1617 , A61K9/1641 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K39/12 , A61K39/39 , A61K47/183 , A61K2039/5252 , A61K2039/542 , A61K2039/552 , A61K2039/55544 , A61K2039/55555 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043 , C12N2720/10034
摘要: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
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公开(公告)号:US5958457A
公开(公告)日:1999-09-28
申请号:US438644
申请日:1995-05-10
申请人: Noemi B. Santiago , Susan Haas , Andrea Leone-Bay
发明人: Noemi B. Santiago , Susan Haas , Andrea Leone-Bay
IPC分类号: A61K9/16 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K39/00 , A61K39/106 , A61K39/12 , A61K39/39 , A61K47/18 , A61K47/42 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A61K9/50
CPC分类号: A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K39/12 , A61K39/39 , A61K47/183 , A61K9/1617 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , A61K2039/5252 , A61K2039/542 , A61K2039/55544 , A61K2039/55555 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18 , C12N2720/10034
摘要: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
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公开(公告)号:US5709861A
公开(公告)日:1998-01-20
申请号:US372208
申请日:1995-01-13
IPC分类号: A61K9/08 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/52 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K39/00 , A61K47/18 , A61K47/20 , A61K47/42 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , C07K14/00
CPC分类号: A61K39/00 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K47/183 , A61K9/1617 , A61K9/1641 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要: The present invention relates to the delivery of antigens. Delivery systems are provided that include the antigen and acylated or sulfonated amino acids or poly amino acids. Methods of preparation and administration of these compositions are also provided.
摘要翻译: 本发明涉及递送抗原。 提供递送系统,其包括抗原和酰化或磺化的氨基酸或聚氨基酸。 还提供了这些组合物的制备和给药方法。
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4.
公开(公告)号:US06391303B1
公开(公告)日:2002-05-21
申请号:US09101921
申请日:1999-05-03
申请人: Susan Haas , Sam J. Milstein
发明人: Susan Haas , Sam J. Milstein
IPC分类号: A61K3900
CPC分类号: A61K39/35 , A61K39/00 , A61K39/0008 , A61K47/183 , A61K2039/542 , A61K31/195 , A61K2300/00
摘要: The present invention relates to methods and pharmaceutical formulations for orally delivering an antigen to induce tolerance. The antigen is combined with derivatized amino acids or salts thereof. The induction of oral tolerance may be applied clinically for the prevention or treatment of auto-immune diseases and clinical allergic hypersensitivities, and for the prevention of allograft rejection.
摘要翻译: 本发明涉及用于口服递送抗原以诱导耐受性的方法和药物制剂。 抗原与衍生的氨基酸或其盐组合。 口服耐受性的诱导可以临床应用于预防或治疗自身免疫性疾病和临床过敏性超敏反应,并用于预防同种异体移植排斥反应。
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公开(公告)号:USD428692S
公开(公告)日:2000-08-01
申请号:US113807
申请日:1999-11-11
申请人: Susan Haas-Chronis
设计人: Susan Haas-Chronis
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