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公开(公告)号：US20230264864A1
公开(公告)日：2023-08-24
申请号：US18006369
申请日：2021-05-27
Applicant: TUNAP GMBH & CO. KG , STEINBEIS-HOCHSCHULE-BERLIN GMBH , OECOPAC GRUNERT VERPACKUNGEN GMBH , TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： André HOFMANN , Marek HAUPTMANN , Jochen GRUNERT , Steffen HEROLD
CPC classification number: B65D41/18 , B31B50/81 , B31F1/0006 , B31B2120/40
Abstract: A cap and a corresponding method of manufacturing the cap for closing a container are described. The cap comprises a spirally wound sleeve comprising a first opening an a second opening, wherein the first opening and the second opening are opposed. Further, the cap comprises a head disk, wherein the head disk is arranged to close the first opening of the sleeve. The sleeve is made of paper. The second opening of the sleeve has a reinforcing element, and the reinforcing element is a structure extending into the interior of the sleeve.
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2.发明公开公开(公告)号：US20230235364A1
公开(公告)日：2023-07-27
申请号：US18046066
申请日：2022-10-12
Applicant: TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： Frank BUCHHOLZ , Martin SCHNEIDER , Felix LANSING
IPC: C12N15/90 , C12N9/22 , C12N15/10 , C12Q1/6869
CPC classification number: C12N15/907 , C12N9/22 , C12N15/1058 , C12Q1/6869
Abstract: The invention provides methods and means for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (in-dels).
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公开(公告)号：US20230183713A1
公开(公告)日：2023-06-15
申请号：US18055545
申请日：2022-11-15
Applicant: TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： Jenna HOERSTEN , Felix LANSING , Frank BUCHHOLZ
Abstract: The invention relates to the field of genome editing and provides a method of generating DNA recombinases or provides DNA recombinases, which efficiently and specifically recombine genomic target sequences as obligate DNA recombinase enzymes. The invention provides a genetically engineered DNA recombining enzyme comprising a complex of a first and a second recombinase enzyme, wherein said first recombinase enzyme and said second recombinase enzyme specifically recognize a first half-site and a second half-site of an upstream target site and/or a downstream target site of a DNA recombinase, wherein said first recombinase enzyme and said second recombinase enzyme each comprises at least one mutation in its catalytic site, wherein said first recombinase enzyme and said second recombinase enzyme carrying said at last one mutation in their catalytic site, when expressed in isolation, do not show the catalytic activity of a DNA recombinase, and wherein said first DNA recombinase enzyme and said second DNA recombinase enzyme carrying said at least one mutation in their catalytic site when co-expressed and forming a complex show the catalytic activity of a DNA recombinase. The invention further relates to nucleic acid molecules encoding said genetically engineered DNA recombinases and complexes, as well as to pharmaceutical compositions comprising the same. The invention further provides the use of said genetically engineered DNA recombinases, complexes, nucleic acid molecules and pharmaceutical compositions in medicine and specifically for treating genetic disorders such as hemophilia A.
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公开(公告)号：US11424861B2
公开(公告)日：2022-08-23
申请号：US16497555
申请日：2018-03-29
Applicant: Massachusetts Institute of Technology , Code On Network Coding, LLC , Technische Universität Dresden
Inventor： Kerim Fouli , Frank Gabriel , Muriel Medard , Sreekrishna Pandi , Simon Wunderlich
IPC: H04L1/00 , H04L1/18 , H04L49/9057
Abstract: A method and apparatus decode packetized data in the presence of packet erasures using a finite sliding window technique. A decoder receives packets containing uncoded and coded symbols. When a packet with a coded symbol is received, the decoder determines whether a packet sequence number is within a sliding window of w consecutive sequence numbers that are no greater than a decoder sequence number, where the number w is fixed prior to encoding. When this is the case, the decoder decodes the coded symbol into one or more of the w input symbols using the coefficient vector. Decoding may use a forward error correcting (FEC) window within the finite sliding window. Decoding also may use a technique of Gaussian elimination to produce a “shifted” row echelon coefficient matrix.
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公开(公告)号：US11098300B2
公开(公告)日：2021-08-24
申请号：US16959841
申请日：2019-02-21
Inventor： Karim Fahmy , Thorsten-Lars Schmidt , Katarina Iric
Abstract: The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.
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Patent Agency Ranking
公开(公告)号：US20210130328A1
公开(公告)日：2021-05-06
申请号：US17087806
申请日：2020-11-03
Applicant: TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： Michael SCHROEDER , Yixin ZHANG , Jörg-Christian HEINRICH , Joachim HAUPT , Petra LENNIG
IPC: C07D403/10 , C07D239/54
Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented.
General formula of these compounds is formula (I): as further defined in claim 1.-
7.发明申请公开(公告)号：US20180270905A1
公开(公告)日：2018-09-20
申请号：US15760190
申请日：2016-09-07
Applicant: TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： Eduard JORSWIECK , Siddharth NAIK , Janis NÖTZEL
Abstract: Method for managing available communication resources in a communication network and node (100, 200) for a communication network The invention concerns a method for managing signaling duties in a communication network and a node for a communication network, the node comprising a resource management. The method comprises using at least one signaling duty concerning a requested service for allocating corresponding communication resource of one of the nodes (200), the signaling duty being assigned to a different, further node (100) and the one node (200) being capable for at least partly providing the service. The method further comprises using the one node and the further node for determining a compensation and providing the compensation to said one node.
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公开(公告)号：US09828030B2
公开(公告)日：2017-11-28
申请号：US14896873
申请日：2014-05-21
Applicant: THYSSENKRUPP STEEL EUROPE AG , TECHNISCHE UNIVERSITÄT DRESDEN , LEICHTBAU-ZENTRUM SACHSEN GMBH
Inventor： Lothar Patberg , Stefan Mayer , Torsten Krahnert , Werner Hufenbach , Enrico Ladusch , Jens Werner , André Kieβling , Alexander Herbig , Jörn Kiele , Martin Lepper
CPC classification number: B62D21/152 , B62D25/08 , B62D25/082 , B62D29/041 , B62D29/043
Abstract: Longitudinal members for motor vehicles may generally include a supporting element that is releasably connectable to an energy absorption mechanism. The supporting element may typically include a joining zone that can be used to secure the supporting element to one or more chassis or drive components of the motor vehicle. The supporting element and the energy absorption mechanism may be comprised of fiber-reinforced plastic. More specifically, the supporting element may be comprised of a plurality of length portions having different fiber orientations. For example, a first length portion may have fibers oriented substantially parallel to a horizontal longitudinal plane about which the supporting element is positioned, whereas a second length portion between the first length portion and the energy absorption mechanism may have intersecting fibers oriented oblique to the horizontal longitudinal plane.
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公开(公告)号：US09783235B2
公开(公告)日：2017-10-10
申请号：US14897065
申请日：2014-05-21
Applicant: THYSSENKRUPP STEEL EUROPE AG , TECHNISCHE UNIVERSITÄT DRESDEN , LEICHTBAU-ZENTRUM SACHSEN GMBH
Inventor： Lothar Patberg , Stefan Mayer , Torsten Krahnert , Werner Hufenbach , Enrico Ladusch , Jens Werner , André Kieβling , Alexander Herbig , Jörn Kiele , Martin Lepper
CPC classification number: B62D21/15 , B60R13/0861 , B62D25/2072 , B62D29/041 , B62D35/02 , Y02T10/88
Abstract: The present disclosure relates to a protective apparatus that can be positioned along an underside of a motor vehicle and, in many cases, near a front or rear region of the motor vehicle. The protective apparatus may include an underbody made from fiber-reinforced plastic for protecting assemblies or components arranged above it against damage as a consequence of stone chipping or ground contact. Further, the underbody may have three-dimensionally structured regions for increasing its rigidity, and the underbody may be designed to absorb chassis and/or crash loads and may include integrated holders for movably attaching chassis links.
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公开(公告)号：US09775068B2
公开(公告)日：2017-09-26
申请号：US14423701
申请日：2013-08-26
Applicant: ACTIX GMBH , TECHNISCHE UNIVERSITÄT DRESDEN
Inventor： Albrecht Fehske , Christian Isheden , Henrik Klessig , Jens Voigt
CPC classification number: H04W28/021 , H04W16/18 , H04W24/02 , H04W28/0226 , H04W28/08
Abstract: The present invention relates to a method for optimizing a real cellular, wireless communication network that combines mobility load balancing (MLB) with coverage and capacity optimization (CCO) in a joint and coordinated optimization. An optimal set of physical base station parameters is determined by performing an iterative direct search. The iterative direct search comprises a partitioning strategy to jointly determine an optimal partition of the served area and an associated optimal load of each of the plurality of base stations for a current set of physical base station parameters for each direct search iteration; said partitioning strategy using an updated value of the received power of the pilot or reference signal for each the plurality of user locations associated with the current set of physical base station parameters for each direct search iteration. (FIG. 1)
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