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    Field deployable brain monitor and method
    1.
    发明授权
    Field deployable brain monitor and method 有权

    公开(公告)号：US11109789B1

    公开(公告)日：2021-09-07

    申请号：US13962533

    申请日：2013-08-08

    申请人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

    发明人： Stéphane Bibian ,  Tatjana Zikov ,  Sankar Barua

    IPC分类号： A61B5/372 ,  A61B5/291

    摘要： A system and method for using electroencephalographic (EEG) signals to monitor brain function, preferably detect occurrence of traumatic brain injury (TBI) to screen, assess, and potentially provide mitigating treatment to improve short and long term adverse outcomes of mild TBI (mTBI) and TBI. The system and method provides a readily available tool to assist in accurate and objective assessment of subjects with TBI, immediately at the point of injury (POI), during transportation, or upon arrival at a care facility, that preferably is applicable without advanced training or expertise.

    Seizure detector, brain dysfunction monitor and method
    3.
    发明授权
    Seizure detector, brain dysfunction monitor and method 有权
    癫痫检测仪，脑功能障碍监测仪及方法

    公开(公告)号：US09554721B1

    公开(公告)日：2017-01-31

    申请号：US12148815

    申请日：2008-04-23

    申请人： Tatjana Zikov ,  Stéphane Bibian ,  Mohammad Modarres

    发明人： Tatjana Zikov ,  Stéphane Bibian ,  Mohammad Modarres

    IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61B5/048

    CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/048 ,  A61B5/1128 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/721 ,  A61B5/7235 ,  A61B5/743 ,  A61N1/36064

    摘要： The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. The various embodiments of the system of the present invention were developed for the brain activity and preferably EEG monitoring of a single patient or multiple patients. Preferably, the system or monitor of the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity. This analysis yields a seizure index whose value is directly related to the current presence of ictal activity in the signal. In addition, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. The real-time seizure index, and the historical seizure probability index, can be used in the context of an emergency and/or clinical situation to assess the status and well being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.

    摘要翻译： 本发明涉及脑功能障碍和癫痫发作检测器监测和系统，以及检测受试者脑功能障碍和/或发作的方法。 本发明的系统的各种实施方案是针对脑活动而开发的，优选地对单个患者或多个患者进行EEG监测。 优选地，本发明的系统或监视器还包括一个或多个发作检测算法。 分析方法被特别优化，以扩大异常大脑活动并最小化正常的背景活动。 该分析产生一个缉获指数，其价值与信号中当前存在的动作直接相关。 此外，基于上述扣押指数的历史值的缉获概率指数被推导出用于诊断目的。 癫痫发作概率指数量化自记录开始以来患者表现出异常脑活动的可能性。 可以在紧急情况和/或临床情况的情况下使用实时癫痫发作指数和历史发作概率指数来评估患者的大脑的状态和健康状况，或者可以用于自动管理治疗停止 临床前出现癫痫发作。

    Method and apparatus for the estimation of anesthesia depth
    4.
    发明授权
    Method and apparatus for the estimation of anesthesia depth 有权
    估计麻醉深度的方法和装置

    公开(公告)号：US07603168B2

    公开(公告)日：2009-10-13

    申请号：US12148151

    申请日：2008-04-17

    申请人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hosaain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell MacLeod

    发明人： Stéphane Bibian ,  Tatjana Zikov ,  Guy Albert Dumont ,  Craig Robert Ries ,  Ernest Puil ,  Hosaain Cyrus Ahmadi ,  Mihai Huzmezan ,  Bernard Ansell MacLeod

    IPC分类号： A61B5/04

    CPC分类号： A61B5/4821 ,  A61B5/048 ,  A61B5/4035 ,  A61B5/7217 ,  A61B5/726 ,  A61B5/7267

    摘要： A method and apparatus to monitor and control the anesthesia state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the anesthesia state of a patient undergoing general anesthesia involve a significant time delay between the patient's true anesthesia state and the computed indices. The present invention reduces this time delay by using a novel analysis technique applied to spontaneous electrophysiological activity. A transformation and statistical analysis of the observed electrophysiological activity is conducted and compared to reference data to provide numerical indicators. In addition, these indicators are consistent with the levels of depression of patients CNS and ANS states. This method is illustrated in detail by CNS monitoring of electroencephalogram signals.

    摘要翻译： 提供了一种用于监测和控制进行全身麻醉的患者的麻醉状态的方法和装置。 以前的自动系统监测患者进行全身麻醉的麻醉状态涉及患者真实麻醉状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发电生理活动的新型分析技术来减少该时间延迟。 对观察到的电生理活动进行转化和统计分析，并与参考数据进行比较以提供数值指标。 此外，这些指标与患者CNS和ANS状态的抑郁水平一致。 CNS对脑电图信号的监测详细说明了该方法。

    Method and system for acquiring biosignals in the presence of HF interference
    5.
    发明授权
    Method and system for acquiring biosignals in the presence of HF interference 有权
    在存在HF干扰的情况下获取生物信号的方法和系统

    公开(公告)号：US09439601B1

    公开(公告)日：2016-09-13

    申请号：US14687159

    申请日：2015-04-15

    申请人： Thomas V. Saliga ,  Stéphane Bibian ,  Tatjana Zikov

    发明人： Thomas V. Saliga ,  Stéphane Bibian ,  Tatjana Zikov

    IPC分类号： H03F1/26 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0428 ,  A61B5/0496

    CPC分类号： A61B5/7217 ,  A61B5/04004 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/725 ,  A61B18/1402 ,  A61B2018/00601 ,  A61B2018/00839 ,  A61B2018/1412 ,  G01R29/26

    摘要： The present invention, herein is a method and apparatus that significantly limits the effect of high frequency (“HF”) interferences on acquired electro-physiological signals, such as the EEG and EMG. Preferably, this method comprises of two separate electronic circuitries and steps or electronics for processing the signals. One circuit is used to block the transmission of HF interferences to the instrumentation amplifiers. It is comprised of a front-end active filter, a low frequency electromagnetic interference (“EMI”) shield, and an isolation barrier interface which isolates the patient from earth ground. The second circuit is used to measure the difference in potential between the two isolated sides of the isolation barrier. This so-called “cross-barrier” voltage is directly representative of the interference level that the instrumentation amplifier is subjected to. This circuit is used to confirm that the acquired signals are not corrupted by the interference.

    摘要翻译： 本发明是一种显着限制高频（“HF”）干扰对所获得的电生理信号如EEG和EMG的影响的方法和装置。 优选地，该方法包括用于处理信号的两个单独的电子电路和步骤或电子装置。 一个电路用于阻止HF干扰对仪表放大器的传输。 它由前端有源滤波器，低频电磁干扰（“EMI”）屏蔽以及将患者与地面隔离的隔离屏障接口组成。 第二电路用于测量隔离屏障的两个隔离侧之间的电位差。 这种所谓的“交叉屏障”电压直接代表了仪表放大器受到的干扰电平。 该电路用于确认所采集的信号没有被干扰破坏。

    MULTI-CHANNEL BRAIN OR CORTICAL ACTIVITY MONITORING AND METHOD
    7.
    发明申请
    MULTI-CHANNEL BRAIN OR CORTICAL ACTIVITY MONITORING AND METHOD 有权
    多通道脑或反应活动监测和方法

    公开(公告)号：US20110130675A1

    公开(公告)日：2011-06-02

    申请号：US12628568

    申请日：2009-12-01

    申请人： Stéphane Bibian ,  Tatjana Zikov

    发明人： Stéphane Bibian ,  Tatjana Zikov

    IPC分类号： A61B5/0476

    CPC分类号： A61B5/0476 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4821 ,  A61B5/6843 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61M5/1723

    摘要： The present invention relates to a quantitative electroencephalogram (QEEG) monitor and system capable of monitoring and displaying simultaneously neuropathological characteristic and activity of both sides of a subject's brain. The methods include various indices and examination of differences in these indices by which neurophysiological conditions or problems can be identified and treated. These methods, and the systems and devices using these methods preferably can be used for identifying these neurophysiological conditions or brain dysfunction with monitors and methods for seizure detection, for sedation monitoring, for anesthesia monitoring, and the like. These bilateral brain monitoring methods and systems, and the devices using these methods can be used by individuals or clinicians with little or no training in signal analysis or processing. These bilateral monitoring methods can also be used in a range of applications.

    摘要翻译： 本发明涉及一种能够同时监测和显示受试者脑部两侧的神经病理特征和活动的定量脑电图（QEEG）监测器和系统。 这些方法包括各种指标和检查这些指标的差异，通过这些指标可以识别和治疗神经生理学条件或问题。 使用这些方法的这些方法以及使用这些方法的系统和装置优选地可以用于通过用于缉获检测的监测器和方法来鉴别这些神经生理学状况或脑功能障碍，用于镇静监测，用于麻醉监测等。 这些双侧大脑监测方法和系统以及使用这些方法的装置可以由信号分析或处理中很少或根本没有训练的个人或临床医生使用。 这些双边监测方法也可用于一系列应用。

    Physiological recording device with novel and proprietary connector
    8.
    发明授权
    Physiological recording device with novel and proprietary connector 有权

    公开(公告)号：US10194823B1

    公开(公告)日：2019-02-05

    申请号：US14874725

    申请日：2015-10-05

    申请人： Stéphane Bibian ,  Tatjana Zikov

    发明人： Stéphane Bibian ,  Tatjana Zikov

    IPC分类号： A61B5/0478 ,  A61B5/0416

    摘要： Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation or to prevent shorting between the adjacent electrodes by preventing the conductive path to be shared. A method of using a set of four such electrodes is also disclosed.

    Method and system for electrode impedance measurement
    9.
    发明授权
    Method and system for electrode impedance measurement 有权

    公开(公告)号：US09980662B2

    公开(公告)日：2018-05-29

    申请号：US13110455

    申请日：2011-05-18

    申请人： Stéphane Bibian ,  Tatjana Zikov

    发明人： Stéphane Bibian ,  Tatjana Zikov

    IPC分类号： A61B5/0478 ,  A61B5/053 ,  A61B5/00

    CPC分类号： A61B5/0478 ,  A61B5/053 ,  A61B5/4094 ,  A61B5/4806 ,  A61B5/4821 ,  A61B5/7203 ,  A61B5/7221

    摘要： The present invention relates to measuring electrical impedance, and particularly to measuring impedance of electrodes used to acquire physiological signals. The measurement of electrode impedance is typically performed to ensure proper electrode-to-skin contact, and thus verify the quality of the acquired signals. Electrode-to-skin contact impedance has also clinical utility for monitoring, diagnosis, prognosis or treatment, as it can be used to measure skin conductivity, which is function of physiological processes. The present invention relates in particular to a substantially continuous method for performing such measurement. The measurement is performed in such a way that it does not affect the bioband, the range (or ranges) of frequencies that contains components used for diagnostic, prognostic, triage, and/or treatment purposes. The present invention therefore performs this impedance measurement without affecting the physiological signal while allowing for uninterrupted monitoring of said signal.

    Physiological electrode assembly for fast application
    10.
    发明授权
    Physiological electrode assembly for fast application 有权
    生理电极组件快速应用

    公开(公告)号：US09050015B2

    公开(公告)日：2015-06-09

    申请号：US14324719

    申请日：2014-07-07

    申请人： Stéphane Bibian ,  Tatjana Zikov

    发明人： Stéphane Bibian ,  Tatjana Zikov

    IPC分类号： A61B5/0478 ,  A61B5/0492 ,  A61B5/0496 ,  A61B5/042 ,  A61B5/00 ,  A61B5/0408

    CPC分类号： A61B5/0478 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0492 ,  A61B5/0496 ,  A61B5/6833 ,  A61B5/6839 ,  A61B2562/0209 ,  A61B2562/14 ,  A61B2562/242

    摘要： The present invention relates to a physiological recording electrode, and, more particularly, to an EEG (electroencephalography) recording electrode that can be used without the need for numerous steps in preparing the subject's skin and the electrode itself. The invention further relates to a surface feature or penetrator with a size and shape which that will not bend or break, which limits the depth of application, and/or anchors the electrode or other device during normal application; and a packaging system comprising a well and electrolytic fluid for maintaining a coating of said electrolytic fluid on the surface feature or penetrator.

    摘要翻译： 本发明涉及一种生理记录电极，更具体地说，涉及一种EEG（脑电图）记录电极，其可以在制备受试者的皮肤和电极本身时不需要许多步骤而使用。 本发明还涉及具有不会弯曲或断裂的尺寸和形状的表面特征或穿透器，这限制了施加深度，和/或在正常应用期间锚定电极或其它装置; 以及包括井和电解液的包装系统，用于将所述电解液的涂层保持在表面特征或穿透器上。