公开(公告)号：US20150343093A1

公开(公告)日：2015-12-03

申请号：US14825123

申请日：2015-08-12

申请人： Tehila HYMAN ,  Boaz BRILL

发明人： Tehila HYMAN ,  Boaz BRILL

IPC分类号： A61K49/00

CPC分类号： A61B5/14503 ,  A61B5/0031 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2560/0214 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0056 ,  C07K14/43595 ,  C07K2319/60

摘要： A method is provided, including implanting a chamber containing cells in a subject, and subsequently administering, to the subject, a drug capable of killing the cells. For example, the drug may be administered after the cells cease to function for their intended purpose, or if the cells escape from the implanted chamber. Alternatively, the drug may be administered to kill the cells while the cells are in the implanted chamber. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括将包含细胞的腔室植入受试者中，随后向受试者施用能够杀死细胞的药物。 例如，药物可以在细胞停止其预期目的的功能之后，或者如果细胞从注射室逸出，则可以给药。 或者，可以施用药物以在细胞处于植入室中时杀死细胞。 还描述了其它实施例。

公开(公告)号：US20100160749A1

公开(公告)日：2010-06-24

申请号：US12344103

申请日：2008-12-24

申请人： Yossi GROSS ,  Tehila Hyman ,  Tamir Gil

发明人： Yossi GROSS ,  Tehila Hyman ,  Tamir Gil

IPC分类号： A61B5/1459

CPC分类号： A61B5/14532 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/6846

摘要： Apparatus is provided, including a support configured to be implanted within a body of a subject and a sampling region coupled to the support. The apparatus is configured to passively allow passage through the sampling region of at least a portion of fluid from the subject. The apparatus also comprises an optical measuring device in optical communication with the sampling region. The optical measuring device comprises at least one light source configured to transmit light through at least a portion of the fluid, and at least one sensor configured to measure a parameter of the fluid by detecting light passing through the fluid. Other embodiments are also described.

摘要翻译： 提供了一种装置，包括被配置为植入受试者的身体内的支撑体和连接到支撑件的采样区域。 该装置被配置为被动地允许通过来自受试者的至少一部分流体的采样区域。 该装置还包括与采样区域光学通信的光学测量装置。 所述光学测量装置包括至少一个光源，所述至少一个光源被配置为透过至少一部分所述流体的光;以及至少一个传感器，被配置为通过检测穿过所述流体的光来测量所述流体的参数。 还描述了其它实施例。

公开(公告)号：US07951357B2

公开(公告)日：2011-05-31

申请号：US11632587

申请日：2005-07-13

申请人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

发明人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

IPC分类号： A61B5/00 ,  C07H21/04 ,  C07K14/00 ,  C12N15/85

CPC分类号： C07K14/43595 ,  A61B5/14532 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0056 ,  C07K2319/60 ,  G01N33/54373

摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).

摘要翻译： 提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。 配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。 还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。 传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

公开(公告)号：US20080319287A1

公开(公告)日：2008-12-25

申请号：US11632587

申请日：2005-07-13

申请人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

发明人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

IPC分类号： A61B5/145 ,  G01N33/66 ,  C12Q1/37 ,  A61M5/00 ,  C12Q1/54

CPC分类号： C07K14/43595 ,  A61B5/14532 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0056 ,  C07K2319/60 ,  G01N33/54373

摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).

摘要翻译： 提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。 配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。 还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。 传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

公开(公告)号：US20100202966A1

公开(公告)日：2010-08-12

申请号：US12225749

申请日：2007-03-28

申请人： Yossi Gross ,  Tehila Hyman

发明人： Yossi Gross ,  Tehila Hyman

IPC分类号： A61K49/00 ,  A61B5/1459 ,  A61B5/1473 ,  A61P43/00

CPC分类号： A61B5/14532 ,  A61B5/14556 ,  A61B5/1459 ,  C07K14/43595 ,  C07K2319/60

摘要： Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described.

摘要翻译： 提供了用于检测受试者中分析物浓度的装置。 该装置包括适于植入受试者的壳体（20）。 壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。 该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。 还描述了其它实施例。

公开(公告)号：US09037205B2

公开(公告)日：2015-05-19

申请号：US13173831

申请日：2011-06-30

申请人： Tamir Gil ,  Yossi Gross ,  Orly Grinberg ,  Itamar Weisman ,  Tehila Hyman ,  Boaz Hyman

发明人： Tamir Gil ,  Yossi Gross ,  Orly Grinberg ,  Itamar Weisman ,  Tehila Hyman ,  Boaz Hyman

IPC分类号： A61B5/1455 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/00

CPC分类号： A61B5/1459 ,  A61B5/0071 ,  A61B5/14532

摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.

摘要翻译： 提供了用于检测分析物的装置，其被配置为植入受试者的身体。 该装置包括具有远端部分的光纤以及可分析物透过的膜。 膜通过装配在纤维的远端部分上至少部分地耦合到纤维的远端部分并且围绕取样区域。 还描述了其它实施例。

公开(公告)号：US20130006069A1

公开(公告)日：2013-01-03

申请号：US13173831

申请日：2011-06-30

申请人： Tamir GIL ,  Yossi GROSS ,  Orly GRINBERG ,  Itamar WEISMAN ,  Tehila HYMAN ,  Boaz HYMAN

发明人： Tamir GIL ,  Yossi GROSS ,  Orly GRINBERG ,  Itamar WEISMAN ,  Tehila HYMAN ,  Boaz HYMAN

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0071 ,  A61B5/14532

摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.

摘要翻译： 提供了用于检测分析物的装置，其被配置为植入受试者的身体。 该装置包括具有远端部分的光纤以及可分析物透过的膜。 膜通过装配在纤维的远端部分上至少部分地耦合到纤维的远端部分并且围绕取样区域。 还描述了其它实施例。

公开(公告)号：US20120059232A1

公开(公告)日：2012-03-08

申请号：US13141936

申请日：2009-12-24

申请人： Yossi Gross ,  Tehila Hyman ,  Tamir Gil

发明人： Yossi Gross ,  Tehila Hyman ,  Tamir Gil

IPC分类号： A61B5/1455

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14556 ,  A61B5/14558 ,  A61B5/686 ,  A61B5/6862

摘要： Apparatus is provided, including a support (21) configured to be implanted within a body of a subject and a sampling region (30, 1430) coupled to the support (21). The apparatus is configured to passively allow passage through the sampling region (30, 1430) of at least a portion of fluid from the subject. The apparatus also includes an optical measuring device in optical communication with the sampling region (30, 1430). The optical measuring device comprises at least one light source (40) configured to transmit light through at least a portion of the fluid, and at least one sensor (42) configured to measure a parameter of the fluid by detecting light passing through the fluid. Other applications are also described.

摘要翻译： 提供了一种设备，包括被配置为植入受试者的身体内的支撑件（21）和联接到支撑件（21）的取样区域（30，1430）。 该装置被配置为被动地允许通过来自受试者的至少一部分流体的取样区域（30,1430）。 该装置还包括与采样区域（30,1430）光学通信的光学测量装置。 所述光学测量装置包括被配置为透过至少一部分流体的光的至少一个光源（40）和被配置成通过检测穿过流体的光来测量流体参数的至少一个传感器（42）。 还描述了其它应用。

公开(公告)号：US20110251471A1

公开(公告)日：2011-10-13

申请号：US13089096

申请日：2011-04-18

申请人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

发明人： Yossi Gross ,  Ben-Tsion Williger ,  Tehila Hyman ,  Tova Neufeld

IPC分类号： A61B5/1473 ,  H01M8/16

CPC分类号： C07K14/43595 ,  A61B5/14532 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0056 ,  C07K2319/60 ,  G01N33/54373

摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).

摘要翻译： 提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。 配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。 还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。 传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。