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公开(公告)号：US12209142B2
公开(公告)日：2025-01-28
申请号：US17336276
申请日：2021-06-01
Applicant: Institute for Systems Biology , The United States of America as Represented by The Secretary of the Army
Inventor： James R. Heath , Matthew Idso , Alexander J. Winton , Matthew B. Coppock , Sanchao Liu
Abstract: Disclosed are compounds, compositions, and methods relating to epitope-targeted immunostimulants (EPIs), which comprise a synthetic peptide ligand and an antibody-recruiting moiety. The peptide ligand binds an epitope on a target and the antibody-recruiting moiety recruits antibodies to the target when the EPI is bound to the epitope on the target. Also disclosed are compositions comprising any of the disclosed EPIs. Also disclosed are methods of stimulating an immune reaction to a microorganism or other pathogen in a subject where an EPI is administered to the subject. Also disclosed are methods of identifying the peptide ligand by using multi-omic analysis.
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公开(公告)号：US11958841B2
公开(公告)日：2024-04-16
申请号：US18189286
申请日：2023-03-24
Applicant: DREXEL UNIVERSITY , The Government of the United States of America, as represented by The Secretary of the Army
Inventor： Giuseppe R. Palmese , Santosh K. Yadav , John J. LaScala
IPC: C07D413/06 , C07D307/52 , C07D413/14 , C08G73/02
CPC classification number: C07D413/06 , C07D307/52 , C07D413/14 , C08G73/024 , C08G73/0273
Abstract: Benzoxazine compounds, methods of making them, polymers made therefrom and methods of polymerizing the benzoxazines. These renewable benzoxazine monomers and polymers that utilize the variety of building blocks found in renewable plant biomass, demonstrate excellent processability and large temperature windows for processing of resin systems.
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公开(公告)号：US20240021873A1
公开(公告)日：2024-01-18
申请号：US18131745
申请日：2023-04-06
Applicant: University of Maryland, College Park , The United States of America as Represented by the Secretary of the Army
Inventor： Matthew D. WIDSTROM , Peter KOFINAS , Arthur V. CRESCE , Kang XU
IPC: H01M10/0565 , H01M10/0525 , H01M4/58 , H01M4/505 , H01M4/38
CPC classification number: H01M10/0565 , H01M10/0525 , H01M4/5825 , H01M4/505 , H01M4/38 , H01M2300/0082
Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.
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公开(公告)号：US11650031B2
公开(公告)日：2023-05-16
申请号：US16987933
申请日：2020-08-07
Applicant: Vanderbilt University , The United States of America as Represented by the Secretary of the Army
Inventor： Kevin C. Galloway , Kelsay E. Neely , Aimee J. Valles , Robert J. Clark , Jesse L. Frederick
Abstract: Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure.
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公开(公告)号：US11631892B2
公开(公告)日：2023-04-18
申请号：US16241813
申请日：2019-01-07
Applicant: University of Maryland, College Park , The United States of America as Represented by the Secretary of the Army
Inventor： Matthew D. Widstrom , Peter Kofinas , Arthur V. Cresce , Kang Xu
IPC: H01M10/052 , H01M10/0565 , H01M10/0525 , H01M4/58 , H01M4/505 , H01M4/38
Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.
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Patent Agency Ranking
公开(公告)号：US11566009B1
公开(公告)日：2023-01-31
申请号：US16875544
申请日：2020-05-15
Applicant: Triad National Security, LLC , The United States of America, as represented by the Secretary of the Army
Inventor： David Chavez , Jesse Sabatini , Pablo Guzmán , Leah Wingard , Eric Johnson
IPC: C07D271/06 , C06B25/34
Abstract: Disclosed herein are embodiments of an energetic compound and methods of making and using the same. Energetic compound embodiments disclosed herein exhibit physical and chemical properties that facilitate their use in various applications, such as high energy propellant plasticizers, melt-castable explosives, and the like. Efficient and safe method embodiments for making the disclosed energetic compound embodiments are described herein.
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公开(公告)号：US20220259220A1
公开(公告)日：2022-08-18
申请号：US17530089
申请日：2021-11-18
Applicant: DREXEL UNIVERSITY , The Government of the United States of America as Represented by the Secretary of the Army
Inventor： Joshua Matthew Sadler , John Joseph La Scala , Giuseppe R. Palmese
IPC: C07D493/04 , C08G59/42 , C08L63/00 , C08G59/17
Abstract: This invention outlines a method for synthesizing a blended resin system in a one pot reaction that may utilize, for example, bio-based anhydrosugars such as isosorbide as a principle component to produce isosorbide dimethacrylate and other monomeric materials for thermosetting applications. This invention establishes a one-pot procedure for reacting a hydroxy group containing compound with methacrylic anhydride in the first step and using the by-product methacrylic acid to react with glycidyl ethers to form additional methacrylate compounds in the second step. This methodology can be formulated to produce a wide array of resin systems that have controlled ratios of hydroxy group containing compound/cross-linker/reactive diluent. Additionally, the novel resin systems may be partially to fully bio-based, promoting global sustainability and reducing costs, and when free radically polymerized have properties that meet or exceed their petroleum derived counterparts.
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公开(公告)号：US11208420B2
公开(公告)日：2021-12-28
申请号：US16462741
申请日：2017-11-16
Applicant: DREXEL UNIVERSITY , The Government of the United States of America as Represented by the Secretary of the Army
Inventor： Joshua Matthew Sadler , John Joseph La Scala , Giuseppe R. Palmese
Abstract: This invention outlines a method for synthesizing a blended resin system in a one pot reaction that may utilize, for example, bio-based anhydrosugars such as isosorbide as a principle component to produce isosorbide dimethacrylate and other monomeric materials for thermosetting applications. This invention establishes a one-pot procedure for reacting a hydroxy group containing compound with methacrylic anhydride in the first step and using the by-product methacrylic acid to react with glycidyl ethers to form additional methacrylate compounds in the second step. This methodology can be formulated to produce a wide array of resin systems that have controlled ratios of hydroxy group containing compound/crosslinker/reactive diluent. Additionally, the novel resin systems may be partially to fully biobased, promoting global sustainability and reducing costs, and when free radically polymerized have properties that meet or exceed their petroleum derived counterparts.
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公开(公告)号：US11135555B2
公开(公告)日：2021-10-05
申请号：US16821477
申请日：2020-03-17
Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY
Inventor： Christopher S. Griggs , Jose A. Mattei-Sosa , Luke A. Gurtowski , Lauren F. Greenlee , Mojtaba Abolhassani
IPC: B01D69/14 , B01D67/00 , C02F1/44 , B01D69/02 , B01D71/02 , B01D71/08 , B01D63/10 , B01D69/06 , C02F101/30
Abstract: This invention relates generally to a chitosan-graphene oxide membrane and process of making the same. The nanocomposite membrane can filter water and remove contaminants without fouling like other commercially-available polymer-based water filters. The membrane can be used as a flat sheet filter or can be engineered in a spiral filtration module. The membrane is scalable and tunable for many water contaminants including pharmaceuticals, pesticides, herbicides, and other organic chemicals. The membrane uses chitosan, which is low-cost, renewable biopolymer typically considered to be a waste product and the second most abundant biopolymer on Earth, thus making the membrane an environmentally-friendly product choice.
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公开(公告)号：US10881684B2
公开(公告)日：2021-01-05
申请号：US16083497
申请日：2017-06-26
Inventor： Robert W. Kaminski , Kevin R. Turbyfill , Edwin V. Oaks , Kristen Clarkson
IPC: A61K31/739 , A61K39/39 , A61P37/04 , A61K39/112 , C07K14/25 , A61K38/16 , A61K45/06 , A61K47/69 , A61K47/61 , A61K9/00 , A61K39/00
Abstract: Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof.
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