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19 条记录 (耗时 0.035 秒)

    Ultraviolet Sterilizing Drainage Catheter
    2.
    发明申请
    Ultraviolet Sterilizing Drainage Catheter 审中-公开
    紫外线消毒导尿管

    公开(公告)号：US20150126976A1

    公开(公告)日：2015-05-07

    申请号：US14535296

    申请日：2014-11-06

    申请人： The University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs

    发明人： Cha-Min Tang ,  Paul E. Bigeleisen ,  Samuel M. Galvagno, JR. ,  Mark E. Shirtliff

    IPC分类号： A61M25/00 ,  A61M1/00

    CPC分类号： A61M25/0043 ,  A61L29/06 ,  A61M25/0012 ,  A61M25/0017 ,  A61M25/0045 ,  A61M25/04 ,  A61M27/00 ,  A61M2025/0056 ,  A61M2202/0496 ,  A61M2205/587 ,  Y10T29/49016 ,  C08L83/04

    摘要： A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

    摘要翻译： 本文公开的装置包括管状构件，其是柔性的并且构造成接收来自UV照明联接器的紫外线（UV）光。 所述管状构件包含限定所述管状构件内的纵向内部空间的内腔，由限定所述内腔的外边界的内壁界定的管状体和限定所述管状构件的外表面的外壁，至少一个光纤设置 在所述内部空间外部不平行于所述内腔的轴线并且适于接收来自所述UV照明联接器的UV光，以及保护部件，其适于防止从所述光纤发射的所有紫外线的实质上离开所述外壁。 本文还公开了制造和使用这些装置的方法。

    Functional myelination of neurons
    5.
    发明授权
    Functional myelination of neurons 有权

    公开(公告)号：US10920194B2

    公开(公告)日：2021-02-16

    申请号：US15802845

    申请日：2017-11-03

    申请人： The University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs

    发明人： Thomas Hornyak ,  Sandeep Joshi

    IPC分类号： C12N5/0797 ,  A61K35/36 ,  C12N5/079 ,  C12N5/071

    摘要： Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker Gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. These cells of neural crest lineage can be used to produce a dense myelin sheath on neurons which lack myelin due to genetic defect, trauma, toxin, infection, or disease process. Therefore, embodiments of the invention provide methods for preparing such cells, the cells themselves and compositions containing the cells, as well as methods for using the cells.

    Plasmonic substrates for metal-enhanced fluorescence based sensing, imaging and assays for cells
    6.
    发明授权
    Plasmonic substrates for metal-enhanced fluorescence based sensing, imaging and assays for cells 有权

    公开(公告)号：US10571465B2

    公开(公告)日：2020-02-25

    申请号：US14965560

    申请日：2015-12-10

    申请人： The University of Maryland, Baltimore

    发明人： Henryk Szmacinski ,  Joseph R. Lakowicz

    IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N21/64 ,  G01N21/27

    摘要： Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.

    C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity
    8.
    发明授权
    C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity 有权

    公开(公告)号：US10098896B2

    公开(公告)日：2018-10-16

    申请号：US15159117

    申请日：2016-05-19

    申请人： The University of Maryland, Baltimore

    发明人： Angela Brodie ,  Vincent C. O. Njar

    IPC分类号： A61K31/58 ,  C07J43/00

    摘要： Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines. The compounds are potent inhibitors of human CYP17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds are useful for the treatment of human prostate cancer.

    Methods of Generating Mature Human Muscle Fibers
    9.
    发明申请
    Methods of Generating Mature Human Muscle Fibers 审中-公开
    生成成熟肌肉纤维的方法

    公开(公告)号：US20160256681A1

    公开(公告)日：2016-09-08

    申请号：US15029191

    申请日：2014-10-17

    申请人： THE UNIVERSITY OF MARYLAND, BALTIMORE

    发明人： Robert J. Bloch ,  Andrea O'Neill ,  Joseph A. Roche ,  Paraskevi Sakellariou

    IPC分类号： A61N1/32 ,  A61F2/08 ,  A61N1/36 ,  A61K35/34 ,  A01K67/027

    CPC分类号： A61N1/326 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/035 ,  A61F2/08 ,  A61F2002/0894 ,  A61K35/34 ,  A61N1/36003

    摘要： Studies of the pathogenic mechanisms underlying human myopathies and muscular dystrophies often require animal models, but models of some human diseases are not yet available. The present invention provides methods to promote the engraftment and development of myogenic cells from individuals with such diseases into mature muscle tissue in mice to treat muscle diseases, muscle injury and reduced muscle function. Immortalized human myogenic precursor cells (hMPCs) form mature human myofibers following implantation into the hindlimbs of immunodeficient mice. The engraftment of the cells and their development into mature muscle myofibers is promoted by intermittent neuromuscular electrical stimulation (iNMES) of the peroneal nerve of the engrafted limb. The human myofibers that form are innervated, their contractile apparatus is fully differentiated, and they are comprised of human myonuclei, with minimal contamination by murine myonuclei.

    摘要翻译： 研究人类肌病和肌营养不良的致病机制通常需要动物模型，但是一些人类疾病的模型尚不可用。 本发明提供了促进从这些疾病个体的肌原细胞植入和发育成小鼠成熟肌肉组织以治疗肌肉疾病，肌肉损伤和减少肌肉功能的方法。 永生化的人源性前体细胞（hMPCs）在植入免疫缺陷小鼠的后肢后形成成熟的人肌纤维。 通过间接神经肌肉电刺激（iNMES）促进移植肢体的腓神经，促进细胞的移植及其发育成熟肌肉肌纤维。 形成的人体肌纤维是神经支配的，它们的收缩装置是完全分化的，并且它们由人类的肌核组成，其中小鼠的核膜被最少的污染。

    Tamm Structures for Enhanced Fluorescence Based Sensing, Imaging and Assays
    10.
    发明申请
    Tamm Structures for Enhanced Fluorescence Based Sensing, Imaging and Assays 有权
    用于增强荧光检测，成像和测定的Tamm结构

    公开(公告)号：US20150338402A1

    公开(公告)日：2015-11-26

    申请号：US14718479

    申请日：2015-05-21

    申请人： The University of Maryland, Baltimore

    发明人： Joseph R. Lakowicz ,  Ramachandram Badugu

    IPC分类号： G01N33/543 ,  G01N21/64

    CPC分类号： G01N33/54373 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6439

    摘要： Techniques for enhanced fluorescence include a Tamm substrate for a target optical frequency comprising a metal nanoscale layer deposited on a Bragg grating. The Bragg grating includes multiple dielectric layers including multiple high index of refraction layers alternating with multiple low index of refraction layers. The dielectric layers are parallel to the metal nanoscale layer; and, the thickness of each dielectric layer is about a fourth of a wavelength of the target optical frequency in the layer. The metal nanoscale layer is configured to host a fluorophore such that an S polarized emission from the fluorophore at the target optical frequency propagates out of the substrate perpendicular to the plurality of dielectric layers.

    摘要翻译： 用于增强荧光的技术包括用于目标光学频率的Tamm衬底，其包括沉积在布拉格光栅上的金属纳米级层。 布拉格光栅包括多个介电层，包括与多个低折射率折射率层交替的多个高折射率折射层。 电介质层平行于金属纳米层; 并且每层介质层的厚度约为该层中目标光频波长的四分之一。 金属纳米层被配置为承载荧光团，使得来自目标光频率处的荧光团的S极化发射从垂直于多个电介质层的衬底传播出来。