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1.发明申请NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 有权新型MACROMOLECULE传输域及其识别方法及其应用公开(公告)号：US20100197598A1
公开(公告)日：2010-08-05
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译： 本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。 还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。
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2.发明授权Macromolecule transduction domains and methods for identification and uses thereof 有权大分子转导结构域及其鉴定及应用的方法公开(公告)号：US08629097B2
公开(公告)日：2014-01-14
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译： 本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。 还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。
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