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1.发明申请NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 有权新型MACROMOLECULE传输域及其识别方法及其应用公开(公告)号：US20100197598A1
公开(公告)日：2010-08-05
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译： 本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。 还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。
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2.发明申请COMBINED USE OF CELL PERMEABLE NANOG AND OCT4 FOR INCREASING SELF-RENEWAL AND SUPPRESSING DIFFERENTIATION OF STEM CELLS 有权细胞渗透性纳米和OCT4的组合使用增加自我更新并抑制干细胞的分化公开(公告)号：US20100099144A1
公开(公告)日：2010-04-22
申请号：US12528919
申请日：2008-02-27
申请人： Dae Woong Jo , Jin Sook Kim , Yun Kyung Park
发明人： Dae Woong Jo , Jin Sook Kim , Yun Kyung Park
CPC分类号： C07K14/4702
摘要： The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells.
摘要翻译： 本发明公开了包含kaposi成纤维细胞生长因子4（kFGF4）衍生的大分子转导结构域（MTD）的细胞渗透性Nanog和Oct4重组蛋白。 还公开了编码细胞渗透性Nanog和Oct4重组蛋白的多核苷酸，通过与细胞渗透性Nanog和Oct4重组蛋白组合处理细胞，增加自我更新和抑制干细胞分化的方法，以及细胞的组合使用 可渗透的Nanog和Oct4重组蛋白，用于增强自我更新和抑制干细胞的分化。
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公开(公告)号：US5686458A
公开(公告)日：1997-11-11
申请号：US464796
申请日：1995-06-26
申请人： Jong Wook Lee , Jeong Seok Chae , Chang Seop Kim , Jae Kyu Kim , Dae Sung Lim , Jeong Won Lee , Moon Kyu Shon , Dae Woong Jo
发明人： Jong Wook Lee , Jeong Seok Chae , Chang Seop Kim , Jae Kyu Kim , Dae Sung Lim , Jeong Won Lee , Moon Kyu Shon , Dae Woong Jo
IPC分类号： C07D239/84 , A61K31/505 , A61K31/517 , A61P1/04 , C07D401/04 , C07D403/02
CPC分类号： C07D401/04
摘要： A quinazoline derivative represented by formula(I) or a pharmaceutically acceptable salt thereof is useful for the treatment of peptic ulcer, wherein: ##STR1## R.sub.1 and R.sub.2 are each hydrogen or a C.sub.1 -C.sub.4 alkyl group; R.sub.3 is hydrogen or a halogen; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9, which may be the same or different, are each hydrogen, a C.sub.1 -C.sub.4 alkyl group, a cyclopropyl group, or a C.sub.1 -C.sub.4 alkyl group substituted with a halogen; and R.sub.10 is a methoxy group.
摘要翻译： PCT No.PCT / KR93 / 00096 Sec。 371日期：1995年6月26日 102（e）日期1995年6月26日PCT提交1993年10月29日PCT公布。 第WO94 / 14795号公报 日本时间1994年7月7日由式（I）表示的喹唑啉衍生物或其药学上可接受的盐可用于治疗消化性溃疡，其中：（I）R 1和R 2各自为氢或C 1 -C 4烷基 ; R3是氢或卤素; R4，R5，R6，R7，R8和R9可以相同或不同，分别为氢，C1-C4烷基，环丙基或被卤素取代的C1-C4烷基; R 10为甲氧基。
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4.发明授权Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells 有权结合使用细胞渗透性Nanog和Oct4来增加自我更新和抑制干细胞分化公开(公告)号：US08158415B2
公开(公告)日：2012-04-17
申请号：US12528919
申请日：2008-02-27
申请人： Dae Woong Jo , Jin Sook Kim , Yun Kyung Park
发明人： Dae Woong Jo , Jin Sook Kim , Yun Kyung Park
CPC分类号： C07K14/4702
摘要： The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells.
摘要翻译： 本发明公开了包含kaposi成纤维细胞生长因子4（kFGF4）衍生的大分子转导结构域（MTD）的细胞渗透性Nanog和Oct4重组蛋白。 还公开了编码细胞渗透性Nanog和Oct4重组蛋白的多核苷酸，通过与细胞渗透性Nanog和Oct4重组蛋白组合处理细胞，增加自我更新和抑制干细胞分化的方法，以及细胞的组合使用 可渗透的Nanog和Oct4重组蛋白，用于增强自我更新和抑制干细胞的分化。
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5.发明授权Macromolecule transduction domains and methods for identification and uses thereof 有权大分子转导结构域及其鉴定及应用的方法公开(公告)号：US08629097B2
公开(公告)日：2014-01-14
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译： 本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。 还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。
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