公开(公告)号：US09724546B2

公开(公告)日：2017-08-08

申请号：US13819454

申请日：2011-06-24

申请人： Adrian Huggins ,  Bernard Robert Money ,  Rajinder Singh ,  David Thomas Steele

发明人： Adrian Huggins ,  Bernard Robert Money ,  Rajinder Singh ,  David Thomas Steele

IPC分类号： A62B27/00 ,  A41D13/11 ,  A62B17/04 ,  A62B7/02 ,  A62B9/00 ,  A62B18/08

CPC分类号： A62B27/00 ,  A41D13/11 ,  A62B7/02 ,  A62B9/006 ,  A62B17/04 ,  A62B18/08

摘要： A respirator has one or more electrodes of e.g. conductive elastomer disposed on the surface of a face sealing member opposite to the surface which seals against the user's face. In use the integrity of the seal formed between the sealing member and the user's face is monitored by monitoring the electrical capacitance across that member between the electrode(s) and the user's face.

公开(公告)号：US20130180523A1

公开(公告)日：2013-07-18

申请号：US13819454

申请日：2011-06-24

申请人： Adrian Huggins ,  Bernard Robert Money ,  Rajinder Singh ,  David Thomas Steele

发明人： Adrian Huggins ,  Bernard Robert Money ,  Rajinder Singh ,  David Thomas Steele

IPC分类号： A62B27/00 ,  A41D13/11 ,  A62B17/04 ,  A62B7/02

CPC分类号： A62B27/00 ,  A41D13/11 ,  A62B7/02 ,  A62B9/006 ,  A62B17/04 ,  A62B18/08

摘要： A respirator has one or more electrodes of e.g. conductive elastomer disposed on the surface of a face sealing member opposite to the surface which seals against the user's face. In use the integrity of the seal formed between the sealing member and the user's face is monitored by monitoring the electrical capacitance across that member between the electrode(s) and the user's face.

摘要翻译： 呼吸器具有一个或多个例如电极的电极。 导电弹性体设置在面密封构件的与表面相对的表面上，该表面密封构件与使用者的脸部密封。 在使用中，通过监测在电极和使用者的脸部之间的该构件的电容来监测形成在密封构件和使用者脸部之间的密封的完整性。

公开(公告)号：USD685582S1

公开(公告)日：2013-07-09

申请号：US29416706

申请日：2012-03-26

申请人： Thomas Steele

设计人： Thomas Steele

公开(公告)号：US6089470A

公开(公告)日：2000-07-18

申请号：US265685

申请日：1999-03-10

申请人： Richard F. Teerman ,  Thomas Steele ,  Philip James Czarnecki

发明人： Richard F. Teerman ,  Thomas Steele ,  Philip James Czarnecki

IPC分类号： F02M51/00 ,  F02M57/02 ,  F02M59/36 ,  F02M59/46 ,  F02M47/02 ,  F02M45/10

CPC分类号： F02M57/023 ,  F02M59/366 ,  F02M59/466

摘要： A control valve assembly for use in a pump or injector of fuel injection systems is provided. A pump or injector body has a pumping chamber, and a valve chamber. The valve chamber defines a valve seat and has an axial guiding portion. A plunger is disposed in the pumping chamber. A valve body disposed in the valve chamber controls fuel. The valve body has a valve stem defining a seating surface. The valve body further has a valve guide in sliding engagement with the valve chamber guiding portion. The valve body is axially movable with respect to the valve chamber over a stroke range. The valve guide has an outer engagement surface that slidingly engages the valve chamber guiding portion with a clearance fit of at least about 5 micrometers in one embodiment. In another embodiment, the axial length of the engagement surface is at most about 7 millimeters. The reduced axial length and/or the clearance fit improve initial sealing performance and sealing performance over the life cycle of the product.

摘要翻译： 提供了一种用于燃料喷射系统的泵或喷射器中的控制阀组件。 泵或喷射器主体具有泵送室和阀室。 阀室限定阀座并具有轴向引导部分。 柱塞被设置在泵送室中。 设置在阀室中的阀体控制燃料。 阀体具有限定座面的阀杆。 阀体还具有与阀室引导部滑动接合的阀引导件。 阀体在行程范围内相对于阀室可轴向移动。 在一个实施例中，阀导向件具有外啮合表面，该外接合表面以至少约5微米的间隙配合滑动地接合阀室引导部分。 在另一个实施例中，接合表面的轴向长度至多约7毫米。 减小的轴向长度和/或间隙配合可提高产品寿命周期内的初始密封性能和密封性能。

公开(公告)号：US20130145962A1

公开(公告)日：2013-06-13

申请号：US13495109

申请日：2012-06-13

申请人： Ram GUPTA ,  Sari-Beth SAMUELS ,  J. Mon Hei ENG ,  Thomas STEELE

发明人： Ram GUPTA ,  Sari-Beth SAMUELS ,  J. Mon Hei ENG ,  Thomas STEELE

IPC分类号： C08K5/1545

CPC分类号： C08K5/1545 ,  B29C41/04 ,  C08K5/00 ,  C08K5/005 ,  C08K5/34 ,  C08K5/51 ,  C08L23/0815 ,  C08L23/10 ,  C08L23/02

摘要： Stabilizer compositions having a chroman-based compound according to Formula (V): and their use in processes for stabilizing organic materials subject to degradation and/or discoloration due to the effects from light, oxygen and heat, and in processes for producing articles from organic materials blended therewith, are provided herein.

摘要翻译： 具有根据式（V）的苯并二氢吡喃基化合物的稳定剂组合物及其在由于光，氧和热的作用而受到降解和/或变色的有机材料的稳定化过程中的用途以及用于生产有机物质的方法 本文提供了与其混合的材料。

公开(公告)号：US08354545B2

公开(公告)日：2013-01-15

申请号：US12747605

申请日：2008-12-10

申请人： Shawn J. Stachel ,  Thomas Steele ,  Alessia Petrocchi

发明人： Shawn J. Stachel ,  Thomas Steele ,  Alessia Petrocchi

IPC分类号： C07D401/06 ,  C07D207/06 ,  C07D403/14 ,  C07D413/06 ,  A61K31/535 ,  A61K31/445 ,  A61K31/415 ,  A61K31/4025

CPC分类号： C07D413/06 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D491/10

摘要： The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂的式（I）的3,4-取代吡咯烷化合物，其可用于治疗其中涉及β-分泌酶的疾病，例如阿尔茨海默病 。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20070254958A1

公开(公告)日：2007-11-01

申请号：US11579049

申请日：2005-05-09

申请人： Craig Coburn ,  Thomas Steele ,  Joseph Vacca ,  David Annis Jr ,  Gergely Makara ,  Huw Nash ,  Praveen Tadikonda ,  Tong Wang

发明人： Craig Coburn ,  Thomas Steele ,  Joseph Vacca ,  David Annis Jr ,  Gergely Makara ,  Huw Nash ,  Praveen Tadikonda ,  Tong Wang

IPC分类号： A61K31/16 ,  A61P25/28 ,  C07C233/05

CPC分类号： C07C235/84 ,  C07C255/57 ,  C07C309/67

摘要： The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的苯甲酰胺化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US11267951B2

公开(公告)日：2022-03-08

申请号：US13495109

申请日：2012-06-13

申请人： Ram Gupta ,  Sari-Beth Samuels ,  J. Mon Hei Eng ,  Thomas Steele

发明人： Ram Gupta ,  Sari-Beth Samuels ,  J. Mon Hei Eng ,  Thomas Steele

IPC分类号： C08K5/00 ,  C07D311/72 ,  C08K5/1545 ,  B29C41/04 ,  C08K5/51 ,  C08L23/08 ,  C08L23/10 ,  C08K5/34 ,  C08L23/12 ,  B29K23/00

摘要： Stabilizer compositions having a chroman-based compound according to Formula (V): and their use in processes for stabilizing organic materials subject to degradation and/or discoloration due to the effects from light, oxygen and heat, and in processes for producing articles from organic materials blended therewith, are provided herein.

公开(公告)号：US08765759B2

公开(公告)日：2014-07-01

申请号：US12934208

申请日：2009-03-24

申请人： Harold G. Selnick ,  Ian M. Bell ,  Melody McWherter ,  Donnette D. Staas ,  Shawn J. Stachel ,  Thomas Steele ,  Craig Stump ,  Michael R. Wood ,  C. Blair Zartman

发明人： Harold G. Selnick ,  Ian M. Bell ,  Melody McWherter ,  Donnette D. Staas ,  Shawn J. Stachel ,  Thomas Steele ,  Craig Stump ,  Michael R. Wood ,  C. Blair Zartman

IPC分类号： A61K31/437 ,  A61K31/497 ,  A61K31/4985

CPC分类号： C07D471/10 ,  C07D403/06 ,  C07D471/20 ,  C07D519/00

摘要： The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及下式的化合物：其中作为拮抗剂的式（其中变量A1，A2，A3，G1，G2，G3，G4，J，Ea，Eb，Ec，R6，R7和Y如本文所述） 的CGRP受体，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08695904B2

公开(公告)日：2014-04-15

申请号：US13063557

申请日：2009-09-16

申请人： Glenn Davis ,  Thomas Steele ,  Jacob Culley

发明人： Glenn Davis ,  Thomas Steele ,  Jacob Culley

IPC分类号： B02C21/02

CPC分类号： B02C21/026 ,  B02C23/02

摘要： A mobile crushing station for receiving and comminuting excavated material from earth moving vehicles provides at least one moveable skip connected to a chassis or frame for receiving material from vehicles, such as rear unloading vehicles like dump trucks. The skips are configured to move to dump material fed into the skips into a feed hopper. The feed hopper is positioned to guide material onto a feed conveyor, such as an inclined apron conveyor. The feed conveyor is configured to transport material to a feed orifice of a crushing device, such as a sizer, a crusher, or a crushing circuit. The crushing device is configured to crush material fed into the crushing device. The crushing device also has a discharge orifice that is positioned above a portion of a discharge conveyor. The mobile crushing station is moveable so it may be repositioned closer to an excavation site as excavation activities progress.

摘要翻译： 用于从地面移动车辆接收和粉碎挖掘的材料的移动破碎站提供至少一个连接到底盘或框架的可移动跳跃件，用于从车辆接收材料，例如卸载车辆如自卸车。 跳槽被配置为移动以将进料到料斗中的料料倾倒到进料斗中。 进料斗定位成将材料引导到进料输送机上，例如倾斜的皮圈输送机。 进料输送机被配置为将材料输送到破碎装置的进料孔，例如筛分机，破碎机或破碎回路。 破碎装置构造成粉碎送入破碎装置的材料。 破碎装置还具有位于排出输送机的一部分上方的排出孔。 移动破碎站是可移动的，因此随着挖掘活动的进行，可以将其重新定位到更靠近挖掘点的位置。