公开(公告)号：US11312043B2

公开(公告)日：2022-04-26

申请号：US13323173

申请日：2011-12-12

Applicant: Ram Gupta ,  Sari-Beth Samuels ,  Thomas Steele ,  J. Mon Hei Eng

Inventor： Ram Gupta ,  Sari-Beth Samuels ,  Thomas Steele ,  J. Mon Hei Eng

IPC: C08K5/00 ,  B29C41/04 ,  C07D311/72 ,  C08K5/34 ,  C08K5/1545 ,  C08L23/08 ,  C08K5/51 ,  B29K23/00

Abstract: The cycle time of polymer compositions subjected to a rotomolding process is improved (i.e., reduced), while the processing window is simultaneously enlarged through the use of a polymer-stabilizing amount of a processing stabilizer system having at least one chroman-based compound according to Formula V:

公开(公告)号：US09440928B2

公开(公告)日：2016-09-13

申请号：US14233307

申请日：2012-07-19

Applicant: Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

Inventor： Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

IPC: C07D233/34 ,  C07D233/36 ,  C07D233/32

CPC classification number: C07D233/36 ,  C07D233/32 ,  C07D233/34

Abstract: The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH2, and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.

Abstract translation: 本发明涉及一种合成N-取代的环状亚烷基脲的方法，该方法是使具有至少两个可以是伯或仲的氨基的多官能脂族胺A，其中至少一个是伯氨基，-NH 2， 并且其中至少一个是仲氨基，NH，另一个氢基团被烃基取代，烃基又可以被羟基，氨基或羧基取代，或 酮羰基或酰肼或腙基或硫醇基，以及至少一种选自伯或仲氨基和羟基的另外的官能团，和选自以下的脂族有机碳酸酯组分C： 的碳酸二烷基酯CD和碳酸亚烷基酯CA。

公开(公告)号：US20120146257A1

公开(公告)日：2012-06-14

申请号：US13323173

申请日：2011-12-12

Applicant: J. Mon Hei ENG ,  Lingqing PENG ,  Sari-Beth SAMUELS ,  Thomas STEELE ,  Ram GUPTA

Inventor： J. Mon Hei ENG ,  Lingqing PENG ,  Sari-Beth SAMUELS ,  Thomas STEELE ,  Ram GUPTA

IPC: B29C39/04

Abstract: The cycle time of polymer compositions subjected to a rotomolding process is improved (i.e., reduced), while the processing window is simultaneously enlarged through the use of a polymer-stabilizing amount of a processing stabilizer system having at least one chroman-based compound according to Formula V:

Abstract translation: 经受滚塑过程的聚合物组合物的循环时间得到改善（即减少），同时通过使用聚合物稳定化量的具有至少一种苯并二氢吡喃基化合物的加工稳定剂体系同时扩大加工窗口，根据 公式V：

公开(公告)号：US07370156B1

公开(公告)日：2008-05-06

申请号：US11035642

申请日：2005-01-14

Applicant: Tung M. Nguyen ,  Ram Gupta ,  Richard Au

Inventor： Tung M. Nguyen ,  Ram Gupta ,  Richard Au

IPC: G06F12/00 ,  G06F13/00

CPC classification number: G06F9/5066

Abstract: Present invention unity parallel processing systems and methods facilitate flexible utilization of sequential program applications in a distributed multi-computer parallel processing environment. The new unity parallel processing architecture enables multiple processing nodes (e.g., SMPs) to perform multi-thread processing within the multiple processing nodes while providing a shared virtual global memory space. Symmetric multiprocessors run shared memory applications with modified runtime guidance directives that permit the memories to emulate a virtual global memory across the plurality of symmetric multiprocessors. Within each SMP node, programs utilize multiple threads according to directives and library calls. Across multiple SMP nodes, each SMP node is treated as a single process with one-way communication to other SMP nodes. Portions of the program data are stored in memories associated with the SMP nodes and communication of the program data across multiple SMP nodes is controlled by unity compiler directives.

Abstract translation: 本发明的统一并行处理系统和方法有助于灵活地利用分布式多计算机并行处理环境中的顺序程序应用。 新的统一并行处理架构使得多个处理节点（例如，SMP）能够在提供共享的虚拟全局存储器空间的同时在多个处理节点内执行多线程处理。 对称多处理器使用经修改的运行时指南指令运行共享存储器应用，允许存储器在多个对称多处理器之间模拟虚拟全局存储器。 在每个SMP节点中，程序根据指令和库调用利用多个线程。 跨多个SMP节点，每个SMP节点被视为单向进程，与其他SMP节点进行单向通信。 程序数据的一部分存储在与SMP节点相关联的存储器中，跨多个SMP节点的程序数据的通信由统一编译器指令控制。

公开(公告)号：US20070015920A1

公开(公告)日：2007-01-18

申请号：US11531932

申请日：2006-09-14

Applicant: Ram Gupta ,  Dennis Jakiela ,  Sampath Venimadhavan ,  Russell Cappadona ,  Venkatrao Pai

Inventor： Ram Gupta ,  Dennis Jakiela ,  Sampath Venimadhavan ,  Russell Cappadona ,  Venkatrao Pai

IPC: C07D251/18

CPC classification number: C07D251/24 ,  C07D251/22

Abstract: It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoter's are combined to form a complex 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.

Abstract translation: 现在已经广泛研究出人意料地发现，2-卤代-4,6-二芳基-1,3,5-三嗪可以以前所未有的选择性，效率，温和条件制备，并且通过氰尿酰卤与 芳族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下进行。 该反应也是前所未有的，因为各种芳族化合物可用于产生广泛选择的2-卤代-4,6-二芳基-1,3,5-三嗪。 该新方法包括在某些反应条件下使用反应促进剂与至少一种路易斯酸组合以促进由氰尿酰卤形成2-卤代-4,6-二芳基-1,3,5-三嗪化合物。 优选将路易斯酸和反应促进剂组合以形成络合物2-卤代-4,6-二芳基-1,3,5-三嗪是制备2-（2-氧芳基）-4,6-二芳基-1,3,5-三嗪的关键中间体， 1,3,5-三嗪类紫外线吸收剂。

公开(公告)号：US10174219B2

公开(公告)日：2019-01-08

申请号：US13876545

申请日：2011-09-23

Applicant: Ram Gupta ,  Lawrence Flood ,  Urvee Treasurer ,  Barry Lawless ,  Colin Brogan

Inventor： Ram Gupta ,  Lawrence Flood ,  Urvee Treasurer ,  Barry Lawless ,  Colin Brogan

IPC: C08G12/36 ,  C09D133/02 ,  C08G12/12 ,  C09D161/24

Abstract: The invention relates to a coating composition comprising a reaction product UA of at least one multifunctional aldehyde A with at least one cyclic urea U, and a crosslinkable resin having at least one kind of functional groups selected from the group consisting of hydroxyl functional groups, acid functional groups, amide functional groups, amino functional groups, imino functional groups, mercaptan functional groups, phosphine functional groups, and carbamate functional groups, characterized in that the degree of etherification, measured as the ratio

公开(公告)号：US09475780B2

公开(公告)日：2016-10-25

申请号：US14233302

申请日：2012-07-19

Applicant: Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

Inventor： Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

IPC: C07C275/00 ,  C07D243/04 ,  C07D233/34 ,  C07D239/10

CPC classification number: C07D243/04 ,  C07D233/34 ,  C07D239/10

Abstract: The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A having two primary amino groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA, wherein the ratio of the amount of substance Ji(—NH2) of primary amino groups —NH2 in the difunctional amine A to the sum M(C) of the amount of substance n(CD) of carbonate groups of a dialkyl carbonate CD and the amount of substance n(CA) of carbonate groups in an alkylene carbonate CA, is at least more than 2, and to the product obtained by this process.

Abstract translation: 本发明涉及一种合成环状亚烷基脲的方法，包括在碱性催化剂，具有两个伯氨基的双官能胺A和选自碳酸二烷基酯CD和 的碳酸亚烷基酯CA，其中二官能胺A中的伯氨基-NH 2的物质Ji（-NH 2）的量与碳酸酯基的物质n（CD）的量的总和M（C）的比率 碳酸二烷基碳酸酯CD和碳酸亚烷基碳酸酯CA中的碳酸酯基团的物质n（CA）的量至少大于2，以及通过该方法得到的产物。

公开(公告)号：US20140179931A1

公开(公告)日：2014-06-26

申请号：US14233307

申请日：2012-07-19

Applicant: Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

Inventor： Ram Gupta ,  Irina Kobylanska ,  Urvee Treasurer ,  Lawrence Flood

IPC: C07D233/36 ,  C07D233/32

CPC classification number: C07D233/36 ,  C07D233/32 ,  C07D233/34

Abstract: The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH2, and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.

Abstract translation: 本发明涉及一种合成N-取代的环状亚烷基脲的方法，该方法是使具有至少两个可以是伯或仲的氨基的多官能脂族胺A，其中至少一个是伯氨基，-NH 2， 并且其中至少一个是仲氨基，NH，另一个氢基团被烃基取代，烃基又可以被羟基，氨基或羧基取代，或 酮羰基或酰肼或腙基或硫醇基，以及至少一种选自伯或仲氨基和羟基的另外的官能团，和选自以下的脂族有机碳酸酯组分C： 的碳酸二烷基酯CD和碳酸亚烷基酯CA。

公开(公告)号：US20130217824A1

公开(公告)日：2013-08-22

申请号：US13876545

申请日：2011-09-23

Applicant: Ram Gupta ,  Lawrence Flood ,  Urvee Treasurer ,  Barry Lawless ,  Colin Brogan

Inventor： Ram Gupta ,  Lawrence Flood ,  Urvee Treasurer ,  Barry Lawless ,  Colin Brogan

IPC: C09D133/02 ,  C08G12/12

CPC classification number: C09D133/02 ,  C08G12/12 ,  C08G12/36 ,  C09D161/24

Abstract: The invention relates to a coating composition comprising a reaction product UA of at least one multifunctional aldehyde A with at least one cyclic urea U, and a crosslinkable resin having at least one kind of functional groups selected from the group consisting of hydroxyl functional groups, acid functional groups, amide functional groups, amino functional groups, imino functional groups, mercaptan functional groups, phosphine functional groups, and carbamate functional groups, characterised in that the degree of etherification, measured as the ratio

Abstract translation: 本发明涉及一种涂料组合物，其包含至少一种多官能醛A与至少一种环状脲U的反应产物UA和具有至少一种选自羟基官能团，酸性的官能团的交联性树脂 官能团，酰胺官能团，氨基官能团，亚氨基官能团，硫醇官能团，膦官能团和氨基甲酸酯官能团，其特征在于醚化度以“（ - 0-R）/ 作为在反应产物UA中化学键合的多官能醛的醛碳原子作为取代基的烷氧基的量的（U）的量<（U））与化合物U的物质“（U）”U 在反应产物中结合，小于0.01mol / mol，以及制备反应产物UA的方法。

公开(公告)号：US20060073561A1

公开(公告)日：2006-04-06

申请号：US10986405

申请日：2004-11-12

Applicant: Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

Inventor： Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

IPC: A61K38/17 ,  C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

Abstract translation: 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。