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公开(公告)号：US07507806B2
公开(公告)日：2009-03-24
申请号：US11203806
申请日：2005-08-15
申请人： Titia de Lange , Joshua Silverman
发明人： Titia de Lange , Joshua Silverman
CPC分类号： C12Q1/485 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.
摘要翻译： 本发明涉及人Rif1（hRif1）核酸序列和由其编码的人Rif1氨基酸序列。 本发明还包括对人Rif1多肽具有免疫学特异性的抗体。 本发明还包括用于检测响应诱导DNA损伤的各种治疗形成的Rif1病灶的方法。 包含Rif1响应于DNA损伤的病灶的形成作为细胞中存在野生型ATM激酶活性的阳性指标，而在这种情况下不存在可检测的Rif1病灶用于鉴定具有降低的ATM激酶活性的细胞。 ATM激酶活性和/或Rif1活性的调节剂和鉴定这种调节剂的方法也包括在本发明中。
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公开(公告)号：US6020166A
公开(公告)日：2000-02-01
申请号：US273378
申请日：1999-03-22
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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公开(公告)号：US5859183A
公开(公告)日：1999-01-12
申请号：US800264
申请日：1997-02-13
IPC分类号： A61K38/00 , C07K14/47 , C07K4/12 , C07K14/435
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了阻碍TRF与其特异性端粒重复序列结合的分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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4.发明授权
公开(公告)号：US5733730A
公开(公告)日：1998-03-31
申请号：US519103
申请日：1995-08-25
申请人： Titia De Lange
发明人： Titia De Lange
摘要： The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.
摘要翻译： 本发明涉及一种编码端粒蛋白的新型核苷酸序列，其结合端粒序列的重复区域以及由此编码的蛋白质。 本发明还包括用于产生端粒蛋白和用核苷酸序列转化的宿主细胞的表达载体。 此外，考虑了对端粒蛋白特异性的抗体，探针和拮抗剂。 确定端粒蛋白拮抗剂的方法，鉴定样品中端粒蛋白的诊断方法以及端粒蛋白的治疗用途，特别是治疗老化和癌症的方法。
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公开(公告)号：US06506587B2
公开(公告)日：2003-01-14
申请号：US09841835
申请日：2001-04-25
申请人： Titia De Lange , Susan Smith
发明人： Titia De Lange , Susan Smith
IPC分类号： C12N910
CPC分类号： C12N9/1077 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： The present invention discloses a unique vertebrate protein, tankyrase that binds to telomeric repeat binding factor 1 (TRF1). Nucleic acids encoding tankyrases are also disclosed. Methods of screening drugs using tankyrase are also included.
摘要翻译： 本发明公开了一种独特的脊椎动物蛋白，与端粒重复结合因子1（TRF1）结合的阻断酶。 还公开了编码油漆酶的核酸。 还包括使用卡拉胶酶筛选药物的方法。
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公开(公告)号：US5917019A
公开(公告)日：1999-06-29
申请号：US18628
申请日：1998-02-04
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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公开(公告)号：US06586577B2
公开(公告)日：2003-07-01
申请号：US09912962
申请日：2001-07-25
IPC分类号： C07H2104
CPC分类号： G01N33/68 , A61K38/00 , C07K14/47 , C07K2319/00
摘要： The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.
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公开(公告)号：US06277613B1
公开(公告)日：2001-08-21
申请号：US09196387
申请日：1998-11-19
申请人： Titia De Lange , Susan Smith
发明人： Titia De Lange , Susan Smith
IPC分类号： C12N910
CPC分类号： C12N9/1077 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： The present invention discloses a unique vertebrate protein, tankyrase that binds to telomeric repeat binding factor 1 (TRF1). Nucleic acids encoding tankyrases are also disclosed. Methods of screening drugs using tankyrase are also included.
摘要翻译： 本发明公开了一种独特的脊椎动物蛋白，与端粒重复结合因子1（TRF1）结合的阻断酶。 还公开了编码油漆酶的核酸。 还包括使用卡拉胶酶筛选药物的方法。
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公开(公告)号：US6022709A
公开(公告)日：2000-02-08
申请号：US209605
申请日：1998-12-11
摘要： The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
摘要翻译： 本发明提供了阻碍TRF与其特异性端粒重复序列结合的分离的改变的脊椎动物端粒重复结合因子（A-TRF）。 还包括编码本发明的A-TRF的相应核酸以及通过A-TRF与TRF缔合形成的异源二聚体。 此外，还包括含有用于治疗诸如共济失调毛细血管扩张症的疾病的A-TRF的药物组合物。 描述制造，纯化和使用本发明的A-TRF的方法。 此外，提出了用于鉴定模拟和/或补充A-TRF的作用的药物的药物筛选试验。
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