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    Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
    4.
    发明申请
    Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same 审中-公开
    用于抑制白细胞介素-12信号的治疗化合物及其使用方法

    公开(公告)号：US20050032748A1

    公开(公告)日：2005-02-10

    申请号：US10909321

    申请日：2004-08-03

    申请人： J. Klein ,  Stephen Klaus ,  Anil Kumar ,  Baoqing Gong

    发明人： J. Klein ,  Stephen Klaus ,  Anil Kumar ,  Baoqing Gong

    IPC分类号： A61K31/00 ,  C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/675 ,  A61K31/519 ,  A61K31/522

    CPC分类号： C07D473/04 ,  A61K31/00 ,  C07D473/06 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

    摘要： Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N,N(R3) and S. Each R1, R2 and R3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(1-20)tetraminoalkyl, C(5-15)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1-11)alkoxyalkyl, and C(1-20)dialkoxyalkyl.

    摘要翻译： 发现具有与五元环结构稠合的六元环结构的新型杂环化合物可用于治疗和预防与受白细胞介素-12（“IL-12”）影响的紊乱相关的症状或表现， ，例如，Th1细胞介导的疾病。 治疗化合物，药学上可接受的衍生物（例如分解的对映异构体，非对映异构体，互变异构体，其盐和溶剂合物）或其前药具有以下通式：每个X，Y和Z独立地选自C （R 3），N，N（R 3）和S.每个R 1，R 2和R 3是取代或未取代的，并且独立地选自氢，卤素，氧代，C（1-20）烷基，C （1-20）羟基烷基，C（1-20）硫代烷基，C（1-20）烷基氨基，C（1-20）烷基氨基烷基，C（1-20）氨基烷基，C（1-20）氨基烷氧羰基，C（1 -20）氨基烷基，C（1-20）三氨基烷基，C（1-20）四氨基烷基，C（5-15）氨基三烷氧基氨基，C（1-20）烷基酰氨基，C（1-20） ）烷基酰氨基烷基，C（1-20）酰氨基烷基，C（1-20）乙酰氨基烷基，C（1-20）烯基，C（1-20）炔基，C（3-8）烷氧基，C（1-11）烷氧基烷基 ，和C（1-20）二烷氧基烷基。

    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
    6.
    发明申请
    Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers 审中-公开
    2-氧戊二酸双加氧酶抑制剂作为γ珠蛋白诱导剂

    公开(公告)号：US20070042937A1

    公开(公告)日：2007-02-22

    申请号：US10566625

    申请日：2004-07-30

    申请人： Stephen Klaus ,  Peter Ratcliffe

    发明人： Stephen Klaus ,  Peter Ratcliffe

    IPC分类号： A61K38/40 ,  A61K48/00 ,  A61K31/7072 ,  A61K31/19

    CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

    摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically γ-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., β thalassemia and sickle cell disease.

    摘要翻译： 本发明提供增加受试者内源性珠蛋白表达，特别是γ-珠蛋白表达的方法。 本发明还提供了用于该方法的化合物和药物。 所述方法对于增加受试者的胎儿血红蛋白产生特别有用，并且可用于治疗各种疾病，例如β地中海贫血和镰状细胞病。

    TRANSACTION PROCESSING ENGINE FOR BILL PAYMENT TRANSACTIONS AND THE LIKE
    9.
    发明申请
    TRANSACTION PROCESSING ENGINE FOR BILL PAYMENT TRANSACTIONS AND THE LIKE 审中-公开
    交易处理发票用于付款交易和类似交易

    公开(公告)号：US20120197788A1

    公开(公告)日：2012-08-02

    申请号：US13358276

    申请日：2012-01-25

    申请人： Hemal Sanghvi ,  Sridhar Ramalingam ,  Rich Ampleman ,  Robert Hoffman ,  Pauline Ow ,  Stephen Klaus ,  Gidget A. Hall

    发明人： Hemal Sanghvi ,  Sridhar Ramalingam ,  Rich Ampleman ,  Robert Hoffman ,  Pauline Ow ,  Stephen Klaus ,  Gidget A. Hall

    IPC分类号： G06Q20/14

    CPC分类号： G06Q20/102 ,  G06Q30/02

    摘要： A payment processing network operator obtains, from customer service providers, a first plurality of messages specifying a plurality of bill payments to a plurality of biller entities. Said first plurality of messages specifies, for each of the bill payments, an amount and an intended one of the biller entities to be paid. Based on the first plurality of messages, the operator of the payment processing network dispatches, to the plurality of biller entities, a second plurality of messages to initiate the plurality of bill payments. The operator of the payment processing network obtains data that specifies when at least some of the first plurality of messages are to be obtained and/or when at least some of the second plurality of messages are to be dispatched. Obtaining the first plurality of messages and/or scheduling dispatching the second plurality of messages are carried out in accordance with the data.

    摘要翻译： 支付处理网络运营商从客户服务提供商获得指定多个账单支付给多个账单实体的第一多个消息。 所述第一多个消息针对每个账单支付指定要支付的账单实体的金额和期望的一个。 基于第一多个消息，支付处理网络的运营商向多个账单实体发送第二多个消息以启动多个账单支付。 支付处理网络的运营商获得指定何时要获得第一多个消息中的至少一些的数据和/或当要发送第二个多个消息中的至少一些消息时的数据。 根据数据执行获取第一多个消息和/或调度第二多个消息的调度。