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公开(公告)号：US08921548B2
公开(公告)日：2014-12-30
申请号：US13277603
申请日：2011-10-20
申请人： Hideko Inoue , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo , Satoshi Seo , Yui Yamada , Hiromi Nowatari
发明人： Hideko Inoue , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo , Satoshi Seo , Yui Yamada , Hiromi Nowatari
IPC分类号： C01G55/00 , C07D239/28 , C07F15/00 , H05B33/14 , H01L51/00 , C09K11/06 , H01L51/50 , H01L51/52 , H01L27/32
CPC分类号： H01L51/0085 , C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/185 , H01L27/18 , H01L27/3244 , H01L27/3283 , H01L51/009 , H01L51/5012 , H01L51/5016 , H01L51/5044 , H01L51/5278 , H01L2251/5361 , H05B33/14
摘要： Provided is a novel substance that can emit phosphorescence. Alternatively, provided is a novel substance with high emission efficiency. An organometallic complex in which a 4-arylpyrimidine derivative is a ligand and iridium is a central metal is provided. Specifically, an organometallic complex having a structure represented by a general formula (G1) is provided. In the general formula (G1), R1 represents a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted aryl group having 6 to 10 carbon atoms, R2 represents any of hydrogen, a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and a substituted or unsubstituted phenyl group, R3 represents hydrogen or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and Ar1 represents a substituted or unsubstituted arylene group having 6 to 10 carbon atoms.
摘要翻译： 提供可以发射磷光的新物质。 或者，提供了具有高排放效率的新型物质。 提供其中4-芳基嘧啶衍生物为配体和铱为中心金属的有机金属络合物。 具体地说，提供具有由通式（G1）表示的结构的有机金属络合物。 在通式（G1）中，R 1表示取代或未取代的碳原子数1〜4的烷基或取代或未取代的碳原子数6〜10的芳基，R 2表示氢，取代或未取代的烷基， 至4个碳原子，以及取代或未取代的苯基，R 3表示氢或取代或未取代的碳原子数1〜4的烷基，Ar 1表示取代或未取代的碳数为6〜10的亚芳基。
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公开(公告)号：US08225552B2
公开(公告)日：2012-07-24
申请号：US12265412
申请日：2008-11-05
CPC分类号： B60J5/06 , E05F15/646 , E05Y2900/531
摘要： A sliding door slides along the side of a vehicle. An electric drive unit is disposed on a floor of the vehicle and a lower guide rail is disposed under the floor. A lower roller bracket coupled to the sliding door moves along the lower guide rail back and forth. A door-opening outer tube mounted to the sliding door extends from the electric drive unit to a rear wire guide at the rear end of the lower guide rail. A door-closing outer tube extends from the electric drive unit to a front wire guide at the front end of the lower guide rail. A door-opening wire extends through the door-opening outer tube from the electric drive unit to the lower roller bracket. A door-closing wire extends through the door-closing outer tube from the electric drive unit to the lower roller bracket.
摘要翻译： 滑动门沿着车辆的侧面滑动。 电驱动单元设置在车辆的地板上，下导轨设置在地板下方。 联接到滑动门的下辊支架来回移动下导轨。 安装到滑动门的门开口外管从电驱动单元延伸到下导轨后端的后导线器。 门关闭外管从电驱动单元延伸到下导轨前端的前导线引导件。 开门线通过门开口外管从电驱动单元延伸到下辊支架。 门关闭线从电动驱动单元延伸穿过门关闭外管到下辊支架。
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公开(公告)号：US07997639B2
公开(公告)日：2011-08-16
申请号：US12236827
申请日：2008-09-24
IPC分类号： B60J5/08
CPC分类号： E05F15/646 , E05Y2900/531
摘要： A lower guide rail is mounted to a lower surface of a vehicle floor panel. Front and rear cable guides are provided on front and rear ends of the lower guide rail. A lower roller bracket fixed to a slide door is guided by the lower guide rail. An electric actuator unit is mounted to the lower surface of the floor panel. The electric actuator unit includes a cable wind/rewind drum. A watertight cover is mounted to the lower surface of the floor panel in a manner to cover the electric actuator unit. A first inner cable is guided by the front cable guide and has one end portion wound on the wind/rewind drum and the other end fixed to the lower roller bracket. A second inner cable is guided by the rear cable guide and has one end portion wound on the wind/rewind drum and the other end fixed to the lower roller bracket.
摘要翻译： 下导轨安装在车辆底板的下表面。 前后电缆导轨设置在下导轨的前端和后端。 固定到滑动门的下辊支架由下导轨引导。 电动执行器单元安装在地板面板的下表面。 电动执行器单元包括电缆风/倒带鼓。 防水罩以覆盖电动执行器单元的方式安装在地板镶板的下表面上。 第一内部电缆由前部电缆引导件引导，并且具有卷绕在风/倒带鼓上的一个端部，另一端固定到下部辊支架。 第二内电缆由后电缆引导件引导，并且具有卷绕在风/倒带鼓上的一个端部部分，另一端固定到下辊支架。
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4.发明授权Light-emitting device, electronic device, and lighting device utilizing phosphorescence 有权发光装置，电子装置以及利用磷光的照明装置公开(公告)号：US09130184B2
公开(公告)日：2015-09-08
申请号：US13457877
申请日：2012-04-27
申请人： Satoshi Seo , Hideko Inoue , Hiromi Seo , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo
发明人： Satoshi Seo , Hideko Inoue , Hiromi Seo , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo
CPC分类号： H01L51/5016 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/185 , H01L27/3206 , H01L27/3209 , H01L51/0085 , H01L51/5068 , H01L51/5265 , H01L51/5278 , H01L2251/5361 , H01L2251/5384
摘要： A new light-emitting device utilizing phosphorescence is provided. Further, an electronic device and a lighting device which utilize phosphorescence are provided. One embodiment of the present invention is a light-emitting device including a phosphorescent organometallic iridium complex comprising iridium and either pyrimidine having an aryl group at the 4-position or 1,3,5-triazine having an aryl group at the 2-position. One of nitrogen in the pyrimidine or 1,3,5-triazine is coordinated to the iridium. Also, each of the pyrimidine and 1,3,5-triazine has a substituent such as an alkyl group or an aryl group. Further the ortho position of the aryl group which is bonded to the 4-position of the pyrimidine or the 2-position of the 1,3,5-triazine is bonded to the iridium.
摘要翻译： 提供了一种利用磷光的新型发光器件。 此外，提供了利用磷光的电子装置和照明装置。 本发明的一个实施方案是包含磷光发光有机金属铱络合物的发光器件，其包含铱和在4-位具有芳基的嘧啶或在2-位具有芳基的1,3,5-三嗪。 嘧啶或1,3,5-三嗪中的氮之一与铱配位。 此外，嘧啶和1,3,5-三嗪中的每一个都具有烷基或芳基等取代基。 此外，键合到嘧啶的4-位或1,3,5-三嗪的2-位的芳基的邻位键合到铱上。
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5.发明授权Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell 有权抑制癌细胞中受体酪氨酸激酶介导的原始存活信号传导的方法公开(公告)号：US09085772B2
公开(公告)日：2015-07-21
申请号：US13976186
申请日：2011-12-26
IPC分类号： C12Q1/68 , C12N15/113 , A61K31/7088 , C12Q1/48 , G01N33/50 , G01N33/574 , G01N33/566 , A61K38/22 , A61K35/17 , A61K35/745
CPC分类号： C12N15/1137 , A61K31/7088 , A61K35/17 , A61K35/745 , A61K38/2271 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/5011 , G01N33/566 , G01N33/57407 , G01N33/57423 , G01N2500/00
摘要： In order to provide a screening method for a compound capable of suppressing a mechanism of ROR1 by targeting ROR1 and to provide a drug comprising as an active ingredient a compound capable of suppressing the mechanism, it has been found out that suppressing a function of ROR1 makes it possible to suppress receptor tyrosine kinase-mediated pro-survival signaling in a cancer cell. Further, it has been found out that suppressing a function of ROR1 also effectively suppresses growth of cancer cell lines having acquired resistance to inhibitors of receptor tyrosine kinases such as EGFR and MET.
摘要翻译： 为了提供能够通过靶向ROR1来抑制ROR1的机制的化合物的筛选方法，并且提供包含作为有效成分的能够抑制机理的化合物的药物，已经发现抑制ROR1的功能使得 可能抑制癌细胞中的受体酪氨酸激酶介导的原始存活信号传导。 此外，已经发现，抑制ROR1的功能还有效地抑制了具有获得性的受体酪氨酸激酶抑制剂如EGFR和MET的耐药性的癌细胞系的生长。
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6.发明申请Light-Emitting Device, Electronic Device, and Lighting Device Utilizing Phosphorescence 有权发光装置，电子装置和利用磷光的照明装置公开(公告)号：US20120274201A1
公开(公告)日：2012-11-01
申请号：US13457877
申请日：2012-04-27
申请人： Satoshi Seo , Hideko Inoue , Hiromi Seo , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo
发明人： Satoshi Seo , Hideko Inoue , Hiromi Seo , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo
CPC分类号： H01L51/5016 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/185 , H01L27/3206 , H01L27/3209 , H01L51/0085 , H01L51/5068 , H01L51/5265 , H01L51/5278 , H01L2251/5361 , H01L2251/5384
摘要： A new light-emitting device utilizing phosphorescence is provided. Further, an electronic device and a lighting device which utilize phosphorescence are provided. One embodiment of the present invention is a light-emitting device including a phosphorescent organometallic iridium complex comprising iridium and either pyrimidine having an aryl group at the 4-position or 1,3,5-triazine having an aryl group at the 2-position. One of nitrogen in the pyrimidine or 1,3,5-triazine is coordinated to the iridium. Also, each of the pyrimidine and 1,3,5-triazine has a substituent such as an alkyl group or an aryl group. Further the ortho position of the aryl group which is bonded to the 4-position of the pyrimidine or the 2-position of the 1,3,5-triazine is bonded to the iridium.
摘要翻译： 提供了一种利用磷光的新型发光器件。 此外，提供了利用磷光的电子装置和照明装置。 本发明的一个实施方案是包含磷光发光有机金属铱络合物的发光器件，其包含铱和在4-位具有芳基的嘧啶或在2-位具有芳基的1,3,5-三嗪。 嘧啶或1,3,5-三嗪中的氮之一与铱配位。 此外，嘧啶和1,3,5-三嗪中的每一个都具有烷基或芳基等取代基。 此外，键合到嘧啶的4-位或1,3,5-三嗪的2-位的芳基的邻位键合到铱上。
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7.发明申请Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device and Lighting Device 有权有机金属配合物，发光元件，发光装置，电子装置及照明装置公开(公告)号：US20120098417A1
公开(公告)日：2012-04-26
申请号：US13277603
申请日：2011-10-20
申请人： Hideko Inoue , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo , Satoshi Seo , Yui Yamada , Hiromi Nowatari
发明人： Hideko Inoue , Tomoya Yamaguchi , Satoko Shitagaki , Takahiro Ushikubo , Satoshi Seo , Yui Yamada , Hiromi Nowatari
CPC分类号： H01L51/0085 , C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/185 , H01L27/18 , H01L27/3244 , H01L27/3283 , H01L51/009 , H01L51/5012 , H01L51/5016 , H01L51/5044 , H01L51/5278 , H01L2251/5361 , H05B33/14
摘要： Provided is a novel substance that can emit phosphorescence. Alternatively, provided is a novel substance with high emission efficiency. An organometallic complex in which a 4-arylpyrimidine derivative is a ligand and iridium is a central metal is provided. Specifically, an organometallic complex having a structure represented by a general formula (G1) is provided. In the general formula (G1), R1 represents a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted aryl group having 6 to 10 carbon atoms, R2 represents any of hydrogen, a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and a substituted or unsubstituted phenyl group, R3 represents hydrogen or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and Ar1 represents a substituted or unsubstituted arylene group having 6 to 10 carbon atoms.
摘要翻译： 提供可以发射磷光的新物质。 或者，提供了具有高排放效率的新型物质。 提供其中4-芳基嘧啶衍生物为配体和铱为中心金属的有机金属配合物。 具体地说，提供具有由通式（G1）表示的结构的有机金属络合物。 在通式（G1）中，R 1表示取代或未取代的碳原子数1〜4的烷基或取代或未取代的碳数为6〜10的芳基，R 2表示氢，取代或未取代的烷基， 至4个碳原子，以及取代或未取代的苯基，R 3表示氢或取代或未取代的碳原子数1〜4的烷基，Ar 1表示取代或未取代的碳数为6〜10的亚芳基。
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公开(公告)号：US20120082986A1
公开(公告)日：2012-04-05
申请号：US13054288
申请日：2009-07-17
IPC分类号： C12Q1/68 , C12Q1/18 , G01N33/566 , C07H21/02 , C12N15/85
CPC分类号： A61K31/7088
摘要： The present inventors revealed a TTF-1-specific oncogenic process by elucidating the molecular mechanism regulated by the master regulatory factor TTF-1. The present inventors focused on the elucidation of the essence of the lineage-specific survival signal which is a novel canceration signal. Thus, the present inventors found that the expression of ROR1, which is a receptor tyrosine kinase, is induced by the master regulatory factor TTF-1, and demonstrated the presence of a characteristic canceration signal transduction system.
摘要翻译： 本发明人通过阐明由主调节因子TTF-1调节的分子机制，发现了TTF-1特异性致癌过程。 本发明人专注于阐明作为新型癌变信号的谱系特异性生存信号的本质。 因此，本发明人发现，作为受体酪氨酸激酶的ROR1的表达由主调控因子TTF-1诱导，并且证明存在特征性癌变信号转导系统。
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公开(公告)号：US20090133333A1
公开(公告)日：2009-05-28
申请号：US12265412
申请日：2008-11-05
IPC分类号： E05F15/10
CPC分类号： B60J5/06 , E05F15/646 , E05Y2900/531
摘要： A sliding door slides along the side of a vehicle. An electric drive unit is disposed on a floor of the vehicle and a lower guide rail is disposed under the floor. A lower roller bracket coupled to the sliding door moves along the lower guide rail back and forth. A door-opening outer tube mounted to the sliding door extends from the electric drive unit to a rear wire guide at the rear end of the lower guide rail. A door-closing outer tube extends from the electric drive unit to a front wire guide at the front end of the lower guide rail. A door-opening wire extends through the door-opening outer tube from the electric drive unit to the lower roller bracket. A door-closing wire extends through the door-closing outer tube from the electric drive unit to the lower roller bracket.
摘要翻译： 滑动门沿着车辆的侧面滑动。 电驱动单元设置在车辆的地板上，下导轨设置在地板下方。 联接到滑动门的下辊支架来回移动下导轨。 安装到滑动门的门开口外管从电驱动单元延伸到下导轨后端的后导线器。 门关闭外管从电驱动单元延伸到下导轨前端的前导线引导件。 开门线通过门开口外管从电驱动单元延伸到下辊支架。 门关闭线从电动驱动单元延伸穿过门关闭外管到下辊支架。
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公开(公告)号：US20090113801A1
公开(公告)日：2009-05-07
申请号：US12236827
申请日：2008-09-24
IPC分类号： E05F15/14
CPC分类号： E05F15/646 , E05Y2900/531
摘要： A lower guide rail is mounted to a lower surface of a vehicle floor panel. Front and rear cable guides are provided on front and rear ends of the lower guide rail. A lower roller bracket fixed to a slide door is guided by the lower guide rail. An electric actuator unit is mounted to the lower surface of the floor panel. The electric actuator unit includes a cable wind/rewind drum. A watertight cover is mounted to the lower surface of the floor panel in a manner to cover the electric actuator unit. A first inner cable is guided by the front cable guide and has one end portion wound on the wind/rewind drum and the other end fixed to the lower roller bracket. A second inner cable is guided by the rear cable guide and has one end portion wound on the wind/rewind drum and the other end fixed to the lower roller bracket.
摘要翻译： 下导轨安装在车辆底板的下表面。 前后电缆导轨设置在下导轨的前端和后端。 固定到滑动门的下辊支架由下导轨引导。 电动执行器单元安装在地板面板的下表面。 电动执行器单元包括电缆风/倒带鼓。 防水罩以覆盖电动执行器单元的方式安装在地板镶板的下表面上。 第一内部电缆由前部电缆引导件引导，并且具有卷绕在风/倒带鼓上的一个端部，另一端固定到下部辊支架。 第二内电缆由后电缆引导件引导，并且具有卷绕在风/倒带鼓上的一个端部部分，另一端固定到下辊支架。
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