公开(公告)号：US20090208978A1

公开(公告)日：2009-08-20

申请号：US12225477

申请日：2007-03-13

申请人： Kazuta Yasui ,  Fumiya Hirayama ,  Rika Furuta ,  Nobuki Matsuyama ,  Yoshitaka Kojima ,  Toru Miyazaki ,  Hisami Ikeda ,  Yoshihisa Watanabe

发明人： Kazuta Yasui ,  Fumiya Hirayama ,  Rika Furuta ,  Nobuki Matsuyama ,  Yoshitaka Kojima ,  Toru Miyazaki ,  Hisami Ikeda ,  Yoshihisa Watanabe

IPC分类号： G01N33/567 ,  C12N15/09 ,  C12N15/07 ,  C12N5/06 ,  C12N5/08

CPC分类号： G01N33/6854 ,  C12N2510/00 ,  G01N33/564 ,  G01N2333/70539 ,  G01N2800/22

摘要： A panel cell for detecting anti-HNA antibody is disclosed. The panel cell is obtained by introducing a DNA coding for an HNA antigen corresponding to the anti-HNA antibody into a cell so as to enable the expression of the DNA under the condition for use in the detection procedure, wherein the cell for DNA introduction exhibits no detectable reaction with anti-HLA-ABC antibody, anti-HLA-DR antibody, anti-HLA-DQ antibody, anti-HLA-DP antibody, anti-HNA-1 antibody, anti-HNA-2a antibody, anti-HNA-3a antibody, anti-HNA-4 antibody, anti-HNA-5 antibody, and serum from normal subject, in the detection procedure. The panel cell allows accurate and rapid detection of granulocyte antibody.

摘要翻译： 公开了一种用于检测抗-HNA抗体的细胞。 通过将编码对应于抗HNA抗体的HNA抗原的DNA导入细胞，使其能够在用于检测步骤的条件下使DNA表达，其中DNA引入的细胞显示出来 抗HLA-ABC抗体，抗HLA-DR抗体，抗HLA-DQ抗体，抗HLA-DP抗体，抗HNA-1抗体，抗HNA-2a抗体，抗HNA- 3a抗体，抗HNA-4抗体，抗-HNA-5抗体，以及来自正常受试者的血清。 面板细胞允许准确和快速检测粒细胞抗体。

公开(公告)号：US08008028B2

公开(公告)日：2011-08-30

申请号：US12225477

申请日：2007-03-13

申请人： Kazuta Yasui ,  Fumiya Hirayama ,  Rika Furuta ,  Nobuki Matsuyama ,  Yoshitaka Kojima ,  Toru Miyazaki ,  Hisami Ikeda ,  Yoshihisa Watanabe

发明人： Kazuta Yasui ,  Fumiya Hirayama ,  Rika Furuta ,  Nobuki Matsuyama ,  Yoshitaka Kojima ,  Toru Miyazaki ,  Hisami Ikeda ,  Yoshihisa Watanabe

IPC分类号： G01N33/53 ,  C12N15/63

CPC分类号： G01N33/6854 ,  C12N2510/00 ,  G01N33/564 ,  G01N2333/70539 ,  G01N2800/22

摘要： A panel cell for detecting anti-HNA antibody is disclosed. The panel cell is obtained by introducing a DNA coding for an HNA antigen corresponding to the anti-HNA antibody into a cell so as to enable the expression of the DNA under the condition for use in the detection procedure, wherein the cell for DNA introduction exhibits no detectable reaction with anti-HLA-ABC antibody, anti-HLA-DR antibody, anti-HLA-DQ antibody, anti-HLA-DP antibody, anti-HNA-1 antibody, anti-HNA-2a antibody, anti-HNA-3a antibody, anti-HNA-4 antibody, anti-HNA-5 antibody, and serum from normal subject, in the detection procedure. The panel cell allows accurate and rapid detection of granulocyte antibody.

摘要翻译： 公开了一种用于检测抗-HNA抗体的细胞。 通过将编码对应于抗HNA抗体的HNA抗原的DNA导入细胞，使其能够在用于检测步骤的条件下使DNA表达，其中DNA引入的细胞显示出来 抗HLA-ABC抗体，抗HLA-DR抗体，抗HLA-DQ抗体，抗HLA-DP抗体，抗HNA-1抗体，抗HNA-2a抗体，抗HNA- 3a抗体，抗HNA-4抗体，抗-HNA-5抗体，以及来自正常受试者的血清。 面板细胞允许准确和快速检测粒细胞抗体。

公开(公告)号：US5009995A

公开(公告)日：1991-04-23

申请号：US166660

申请日：1988-03-11

申请人： Anthony Albino ,  Kenneth Lloyd ,  Hisami Ikeda ,  Lloyd Old

发明人： Anthony Albino ,  Kenneth Lloyd ,  Hisami Ikeda ,  Lloyd Old

IPC分类号： C07K16/30 ,  G01N33/574

CPC分类号： G01N33/5743 ,  C07K16/3053 ,  Y10S530/866

摘要： This invention relates to monoclonal antibodies recognizing the gp130 antigen of human cells. Monoclonal antibodies which recognize distinct determinants on this antigen and methods of detecting the determinants by immunoassay with the monoclonal antibodies which recognize them are disclosed. The monoclonal antibodies are useful in the detection of the gp130 antigen and human cells including melanoma which contain this antigen.

摘要翻译： 本发明涉及识别人细胞的gp130抗原的单克隆抗体。 公开了识别该抗原上的不同决定簇的单克隆抗体和通过用识别它们的单克隆抗体通过免疫测定来检测决定簇的方法。 单克隆抗体可用于检测gp130抗原和人类细胞，包括含有该抗原的黑素瘤。

公开(公告)号：US4808704A

公开(公告)日：1989-02-28

申请号：US868872

申请日：1986-05-22

申请人： Lloyd J. Old ,  Herbert F. Oettgen ,  Hisami Ikeda ,  Lucy T. C. Li ,  Kenneth O. Lloyd ,  Wolfgang G. Dippold

发明人： Lloyd J. Old ,  Herbert F. Oettgen ,  Hisami Ikeda ,  Lucy T. C. Li ,  Kenneth O. Lloyd ,  Wolfgang G. Dippold

IPC分类号： C07K16/30 ,  C12N5/02 ,  A61K39/395 ,  C12N5/00 ,  C12N15/00 ,  C12P21/00

CPC分类号： C07K16/3053

摘要： Monoclonal antibody recognizing human melanoma cells, method of production and use.

摘要翻译： 识别人黑素瘤细胞的单克隆抗体，生产和使用方法。