公开(公告)号：US08414929B2

公开(公告)日：2013-04-09

申请号：US12528103

申请日：2008-02-21

申请人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

发明人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

IPC分类号： A61F2/00 ,  A61K35/12 ,  A61K35/54 ,  A01N63/00 ,  A01N65/00

CPC分类号： A61L27/3604

摘要： The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.

摘要翻译： 干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造，可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥，使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时，羊膜仍具有构成新鲜羊膜的上皮细胞，基底膜和结缔组织。 干燥的羊膜可用作诸如硬脑膜，meninx，心包膜，胸膜和腹膜的活体中的膜组织的医用替代膜。

公开(公告)号：US08932641B2

公开(公告)日：2015-01-13

申请号：US11990904

申请日：2006-08-18

申请人： Toshio Nikaido ,  Toshiko Yoshida ,  Motonori Okabe ,  Ayaka Toda ,  Kiyotaka Kitagawa ,  Masahiko Arakawa

发明人： Toshio Nikaido ,  Toshiko Yoshida ,  Motonori Okabe ,  Ayaka Toda ,  Kiyotaka Kitagawa ,  Masahiko Arakawa

IPC分类号： A61K35/50 ,  A61L27/36 ,  A01N1/02 ,  C12N5/00

CPC分类号： A61L27/3641 ,  A01N1/02 ,  A01N1/0205 ,  A01N1/0231 ,  A01N1/0289 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L2430/40 ,  C12N5/0068 ,  C12N2533/92

摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.

摘要翻译： 本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存​​。 通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热 设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压 加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。

公开(公告)号：US20100098743A1

公开(公告)日：2010-04-22

申请号：US12528103

申请日：2008-02-21

申请人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

发明人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

IPC分类号： A61K9/00 ,  A61K45/00 ,  A61P43/00

CPC分类号： A61L27/3604

摘要： An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not suitable for use as a substitute membrane for a membrane tissue in a living body, and to provide a novel medical substitute membrane composed of a dried amniotic membrane, which can be used as a substitute membrane for a membrane tissue in a living body. The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.

摘要翻译： 本发明的目的在于克服在细胞膜或羊膜组织中引起损伤的常规冻干羊膜等的缺点，因此不适合用作生物体中的膜组织的替代膜， 提供由干燥羊膜构成的新型医用替代膜，其可以用作活体中的膜组织的替代膜。 干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造，可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥，使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时，羊膜仍具有构成新鲜羊膜的上皮细胞，基底膜和结缔组织。 干燥的羊膜可用作诸如硬脑膜，meninx，心包膜，胸膜和腹膜的活体中的膜组织的医用替代膜。

公开(公告)号：US20090258082A1

公开(公告)日：2009-10-15

申请号：US11990904

申请日：2006-08-18

申请人： Toshio Nikaido ,  Toshiko Yoshida ,  Motonori Okabe ,  Ayaka Toda ,  Kiyotaka Kitagawa ,  Masahiko Arakawa

发明人： Toshio Nikaido ,  Toshiko Yoshida ,  Motonori Okabe ,  Ayaka Toda ,  Kiyotaka Kitagawa ,  Masahiko Arakawa

IPC分类号： A61K35/54 ,  A61P27/02

CPC分类号： A61L27/3641 ,  A01N1/02 ,  A01N1/0205 ,  A01N1/0231 ,  A01N1/0289 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L2430/40 ,  C12N5/0068 ,  C12N2533/92

摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.

摘要翻译： 本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存​​。 通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热 设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压 加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。