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    Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods
    2.
    发明授权
    Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods 失效
    N- {2- [4-氨基-2-（乙氧基甲基）-1H-咪唑并[4,5-c]喹啉-1-基] -1,1-二甲基乙基}甲磺酰胺的酰胺和氨基甲酸酯衍生物和方法

    公开(公告)号：US08476292B2

    公开(公告)日：2013-07-02

    申请号：US11991663

    申请日：2006-09-08

    申请人： Tushar A. Kshirsagar ,  Shri Niwas ,  Bryon A. Merrill

    发明人： Tushar A. Kshirsagar ,  Shri Niwas ,  Bryon A. Merrill

    IPC分类号： A61K31/437 ,  C07D471/04 ,  C07D471/06

    CPC分类号： C07D471/04

    摘要： Amide and carbamate derivatives N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 酰胺和氨基甲酸酯衍生物N- {2- [4-氨基-2-（乙氧基甲基）-1H-咪唑并[4,5-c]喹啉-1-基] -1,1-二甲基乙基}甲磺酰胺，含有这些化合物的药物组合物 公开了制备化合物的方法，以及这些化合物在调节免疫系统中的用途，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病的方法。

    Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
    5.
    发明授权
    Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds 有权
    取代的手性稠合[1,2]咪唑并[4,5-c]环化合物

    公开(公告)号：US08034938B2

    公开(公告)日：2011-10-11

    申请号：US11813052

    申请日：2005-12-29

    申请人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    发明人： George W. Griesgraber ,  Tushar A. Kshirsagar ,  Sarah J. Slania ,  Michael E. Danielson

    IPC分类号： C07D491/052 ,  C07D491/147 ,  A61K31/436

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在咪唑环1位的稠环中具有-CH（-R1） - 基 其中R1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述砜，肟或羟胺的硫代类似物，含有这些化合物的药物组合物，中间体， 公开了使这些化合物和这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

    Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
    9.
    发明授权
    Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method 失效
    异恶唑，二氢异恶唑和恶二唑取代的咪唑环化合物及方法

    公开(公告)号：US07915281B2

    公开(公告)日：2011-03-29

    申请号：US11570716

    申请日：2005-06-17

    申请人： William H. Moser ,  Joan T. Moseman ,  Tushar A. Kshirsagar ,  Philip D. Heppner

    发明人： William H. Moser ,  Joan T. Moseman ,  Tushar A. Kshirsagar ,  Philip D. Heppner

    IPC分类号： A61K31/437 ,  A61P31/12 ,  A61P35/00 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Imidazo ring compounds, (e.g. imidazo[4,5-c]pyridine, imidazo[4,5-c]quinoline, 6,7,8,9-tetrahydro imidazo[4,5-c]quinoline, and imidazo[4,5-c]naphthyridine compounds) having an isoxazole, dihydroisoxazole, or oxadiazole substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 咪唑环化合物（例如咪唑并[4,5-c]吡啶，咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉和咪唑并[ 在1位具有异恶唑，二氢异恶唑或恶二唑取代基的5-c]萘啶化合物，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成 并且公开了治疗包括病毒和肿瘤疾病在内的疾病。