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公开(公告)号：US11604361B2
公开(公告)日：2023-03-14
申请号：US16765278
申请日：2018-08-03
发明人： Albert Le Floch , Guy Ropars
摘要： The invention relates to an optical device (FILT) for filtering light received, by polarisation or mechanically, from a medium presenting a graphic and/or textual content, characterized in that cycles of opening and closing a vision space, in a visible light spectrum, are realized periodically using the optical device (FILT) at a preset frequency Fd and in that the successive open periods each have a duration (T1) comprised in an interval of values ranging from 15 to 35% of the duration (T) of the realized cycles.
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公开(公告)号：US20220396773A1
公开(公告)日：2022-12-15
申请号：US17776053
申请日：2020-11-13
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE RENNES 1 , ÉCOLE DES HAUTES ÉTUDES EN SANTÉ PUBLIQUE (EHESP)
发明人： Georges BAFFET , Marie CUVELLIER , Frédéric EZAN , Sophie ROSE
摘要： A method of obtaining 3D cell structures including differentiated human hepatic cells. The method includes: a first step of culturing stem cell-derived or immortalized human hepatic progenitors in a non-adherent culture vessel, preferably a low or ultra-low attachment culture vessel; a second step of transferring the stem cell-derived or immortalized human hepatic progenitors to a culture medium including methacrylated gelatin (GelMa), thereby embedding the stem cell-derived or immortalized human hepatic progenitors in a GelMa matrix; and a third step of covering the GelMa matrix with culture medium and culturing the stem cell-derived or immortalized human hepatic progenitors embedded in the GelMa matrix, thereby obtaining 3D cell structures including differentiated human hepatic cells. Also, methods for engineering an artificial liver model or an artificial liver organ, and for assessing in vitro the metabolism, toxicity and/or therapeutic effects of a compound.
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公开(公告)号：US11467160B2
公开(公告)日：2022-10-11
申请号：US16612153
申请日：2018-05-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Rennes 1 , Centre Eugene Marquis , Enios Applications Private Limited Company
IPC分类号： G01N33/574 , A61P35/00 , A61K31/506
摘要： The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.
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公开(公告)号：US20210183340A1
公开(公告)日：2021-06-17
申请号：US16764737
申请日：2018-08-03
发明人： Albert LE FLOCH , Guy ROPARS
摘要： A method for displaying graphical content in a playback device, the graphical content being displayed and erased periodically on the display device according to successive cycles that take place at a predetermined frequency (Fd) and in that the successive display periods each have a duration (T1) comprised in an interval of values ranging from 15 to 30% of the duration (T) of the cycles that have taken place.
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公开(公告)号：US20200310141A1
公开(公告)日：2020-10-01
申请号：US16765278
申请日：2018-08-03
发明人： Albert LE FLOCH , Guy ROPARS
摘要： The invention relates to an optical device (FILT) for filtering light received, by polarisation or mechanically, from a medium presenting a graphic and/or textual content, characterized in that cycles of opening and closing a vision space, in a visible light spectrum, are realized periodically using the optical device (FILT) at a preset frequency Fd and in that the successive open periods each have a duration (T1) comprised in an interval of values ranging from 15 to 35% of the duration (T) of the realized cycles.
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6.发明申请DEVICE FOR THE TREATMENT OF SLEEP APNEA SYNDROME IN A PATIENT BY KINESTHETIC STIMULATION 审中-公开通过生殖刺激治疗患者睡眠APNEA综合征的手段公开(公告)号：US20150224018A1
公开(公告)日：2015-08-13
申请号：US14617534
申请日：2015-02-09
申请人： SORIN CRM SAS , INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , UNIVERSITÉ DE RENNES 1 , UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
发明人： Laurence Graindorge , Amel Amblard , Christine Henry , Marcel Limousin , Laure Duchemin Laporte , Alfredo Hernandez , Jean-Louis Pépin
IPC分类号： A61H23/00
CPC分类号： A61H23/00 , A61B5/024 , A61B5/4812 , A61B5/4818 , A61H23/02 , A61H2201/10 , A61H2201/165 , A61H2201/5058 , A61H2230/04 , A61H2230/06 , A61H2230/105
摘要： A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient
摘要翻译： 用于通过刺激治疗患者的睡眠呼吸暂停的装置。 该装置包括被配置为产生刺激脉冲的发生器，接收由发生器产生的刺激脉冲并将刺激传送给患者的刺激器以及控制器。 控制器被配置为确定患者的睡眠状态，基于休眠状态包括多个睡眠阶段的睡眠状态自适应地控制发生器，并且基于睡眠来调制由发生器产生的刺激脉冲的刺激能量 患者阶段
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公开(公告)号：US20210080461A1
公开(公告)日：2021-03-18
申请号：US16612153
申请日：2018-05-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Rennes 1 , Centre Eugene Marquis , Enios Applications Private Limited Company
IPC分类号： G01N33/574 , A61K31/506 , A61P35/00
摘要： The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.
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8.发明申请公开(公告)号：US20190312655A1
公开(公告)日：2019-10-10
申请号：US16347412
申请日：2017-11-03
摘要： A method for determining a distance to a passive intermodulation source in a device under test, the method comprising transmitting at least two signals with respective different frequencies to the device under test, receiving a complex response signal from the device under test, the complex response signal comprising a passive intermodulation of the at least two signals, generating an autocorrelation matrix using the complex response signal, the autocorrelation matrix representing power information of the complex response signal, decomposing the complex response signal, using the autocorrelation matrix, into a signal component part and a noise component part and determining a distance to the passive intermodulation source in the device under test using the noise and/or signal component part.
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9.发明申请ACTIVE IMPLANTABLE MEDICAL DEVICE FOR HEART FAILURE TREATMENT BY STIMULATION OF THE VAGUS NERVE 审中-公开用于通过刺激VAGUS神经的心脏失效治疗的主动植入式医疗装置公开(公告)号：US20160136428A1
公开(公告)日：2016-05-19
申请号：US14883378
申请日：2015-10-14
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3627
摘要： The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.
摘要翻译： 本发明涉及一种有源可植入医疗装置。 该装置包括VNS脉冲发生器，用于检测患者当前活动水平的活动传感器和处理器。 处理器被配置为收集心脏的电活动，例如患者的当前固有心率。 处理器还基于患者的当前活动水平进一步计算参考心率的值。 从参考心率值构建第一直方图，并且从固有心率值构建第二直方图。 通过比较第一和第二直方图，得出代表病人状况的指标。
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公开(公告)号：US11756689B2
公开(公告)日：2023-09-12
申请号：US16754089
申请日：2018-10-09
申请人： UNIVERSITÉ DE RENNES 1 , INSERM—INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU , QUEEN'S UNIVERSITY
CPC分类号： G16H50/50 , G16H40/60 , A61N1/0534
摘要： A method for simulating a deep-brain stimulation in a computer-assisted platform that includes providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain. The method also includes monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode. The method further includes comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.
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