公开(公告)号：US12156867B2

公开(公告)日：2024-12-03

申请号：US17253883

申请日：2019-06-14

Applicant: UNIVERSITA' DI PISA ,  UNIVERSITA' DEGLI STUDI DI MODENA E REGGIO EMILIA

Inventor： Guido Bocci ,  Teresa Di Desidero ,  Daniela Giuliani ,  Salvatore Guarini ,  Paola Orlandi ,  Alessandra Ottani ,  Carla Maria Francesca Pardini ,  Francesca Vaglini

IPC: A61K31/4164 ,  A61K31/437 ,  A61K45/06 ,  A61P35/00

Abstract: A method of therapeutic treatment of a tumor pathology including melanoma, tumors of the gastrointestinal tract, and/or thyroid carcinoma by administering to a subject in need thereof melanocortin receptor-4 (MC4R) antagonists is provided. The melanocortin receptor-4 antagonists are suitable in a targeted anti-tumor treatment, and particularly in an adjuvant therapy or in a therapy affecting onset and/or progression of tumor metastasis. A pharmaceutical composition including a melanocortin receptor-4 (MC4R) antagonist in a pharmaceutically acceptable vehicle, and in combination with optional adjuvants, stabilizers and/or preservatives, is also provided.

公开(公告)号：US20240252477A1

公开(公告)日：2024-08-01

申请号：US18558810

申请日：2022-05-03

Applicant: UNIVERSITA' DEGLI STUDI DI TORINO (60%) ,  UNIVERSITA' DI PISA (40%)

Inventor： Corrado Blandizzi ,  Carolina Pellegrini ,  Matteo Fornai ,  Luca Antonioli ,  Rocchina Colucci ,  Massimo Bertinaria ,  Elisabetta Marini ,  Valentina Boscaro ,  Simone Gastaldi ,  Mattia Cocco

IPC: A61K31/445 ,  A61K31/192 ,  A61K31/222 ,  A61K31/265 ,  A61K31/40

CPC classification number: A61K31/445 ,  A61K31/192 ,  A61K31/222 ,  A61K31/265 ,  A61K31/40

Abstract: The invention relates to compounds of general formula (I), having inhibitory activity against the NLRP3 inflammasome. Said compounds are useful in the prevention and/or treatment of diseases and/or disorders mediated by the NLRP3 inflammasome.

公开(公告)号：US20230149421A1

公开(公告)日：2023-05-18

申请号：US17915361

申请日：2020-04-07

Applicant: UNIVERSITA' DI PISA ,  NIPPON CHEMIPHAR CO., LTD.

Inventor： Luca Antonioli ,  Corrado Blandizzi ,  Matteo Fornai ,  Carolina Pellegrini ,  Mario Roberto Blandizzi ,  Angela Accaputo

IPC: A61K31/5513 ,  A61P1/04 ,  A61P1/06

CPC classification number: A61K31/5513 ,  A61P1/04 ,  A61P1/06

Abstract: The present invention pertains to medicament for use in preventing or treating irritable bowel syndrome or inflammatory bowel disease, the medicament comprising as an active ingredient a compound having a P2X4 receptor antagonistic action, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210053284A1

公开(公告)日：2021-02-25

申请号：US17052356

申请日：2019-05-03

Applicant: UNIVERSITA' DI PISA

Inventor： Giovanni VOZZI ,  Aurora DE ACUTIS ,  Carmelo DE MARIA ,  Guglielmo PACETTA

IPC: B29C64/209 ,  D01D5/00

Abstract: A combined electrospinning and microextrusion apparatus includes a robotic manipulator having a plurality of degrees of freedom, an end effector supported and movable by the robotic manipulator, a plurality of extruders housed on the end effector, each extruder having an interchangeable nozzle for extrusion of material, a working plane for deposition of extruded material, a pneumatic circuit supplying a fluid flow to the extruders for controlling extrusion of material, and an electric generator selectively activatable to apply a potential difference between the nozzles of the extruders and the working plane. The extruders are capable of operating selectively in microextrusion mode with inactive electric generator or in electrospinning mode with active electric generator, in an independent manner from each other.

公开(公告)号：US10913751B2

公开(公告)日：2021-02-09

申请号：US16616119

申请日：2018-05-30

Applicant: UNIVERSITA' DI PISA

Inventor： Francesco Berti ,  Mauro Pineschi ,  Andrea Menichetti

IPC: C07D498/08 ,  A61P3/10

Abstract: The present invention relates to compounds having structural formula (I) wherein R1 and R2 are defined as set forth in the description. The invention also relates to a process for the manufacture of the above compounds of formula (I), wherein a 4a,7,8,8a-tetrahydropyrido[4,3-e]-1,4,2-dioxazine reacts with a hydride selected from the group consisting of: lithium triethylborohydride (LiBHEt3), sodium triethylborohydride (NaBHEt3), and lithium tetrahydroaluminate (LiAlH4), in the presence of tetrahydrofuran. Furthermore, the invention is aimed at the above compounds of formula (I), or pharmaceutically acceptable salts thereof, for use in medicine, preferably in the treatment of the diabetes and pathologies or conditions correlated thereto.

公开(公告)号：US20240119027A1

公开(公告)日：2024-04-11

申请号：US17938626

申请日：2022-10-06

Applicant: UNIVERSITA' DI PISA

Inventor： Paolo FERRAGINA ,  Giovanni MANZINI ,  Giorgio VINCIGUERRA

IPC: G06F16/14 ,  G06F16/16 ,  G06F16/174

CPC classification number: G06F16/14 ,  G06F16/164 ,  G06F16/1744

Abstract: compression and search process on a data set based on multiple strategies, including extracting a set of raw data and transforming it into a sequence of symbols, manipulating the sequence by combining data structures and one or more (optionally a multiplicity of) compression strategies to obtain compressed and efficiently searchable data, recording the compressed and efficiently searchable data on storage media.

公开(公告)号：US11945161B2

公开(公告)日：2024-04-02

申请号：US17052356

申请日：2019-05-03

Applicant: UNIVERSITA' DI PISA

Inventor： Giovanni Vozzi ,  Aurora De Acutis ,  Carmelo De Maria ,  Guglielmo Pacetta

IPC: B29C64/209 ,  B29C48/02 ,  B29C48/25 ,  B29C64/245 ,  B33Y30/00 ,  D01D5/00 ,  B29L31/00

CPC classification number: B29C64/209 ,  D01D5/0061 ,  B29C48/02 ,  B29C48/266 ,  B29C64/245 ,  B29L2031/753 ,  B33Y30/00

Abstract: A combined electrospinning and microextrusion apparatus includes a robotic manipulator having a plurality of degrees of freedom, an end effector supported and movable by the robotic manipulator, a plurality of extruders housed on the end effector, each extruder having an interchangeable nozzle for extrusion of material, a working plane for deposition of extruded material, a pneumatic circuit supplying a fluid flow to the extruders for controlling extrusion of material, and an electric generator selectively activatable to apply a potential difference between the nozzles of the extruders and the working plane. The extruders are capable of operating selectively in microextrusion mode with inactive electric generator or in electrospinning mode with active electric generator, in an independent manner from each other.

公开(公告)号：US11926061B2

公开(公告)日：2024-03-12

申请号：US17606773

申请日：2020-04-29

Applicant: UNIVERSITA' DI PISA

Inventor： Manolo Garabini ,  Danilo Caporale ,  Alessandro Settimi ,  Lucia Pallottino ,  Manuel Giuseppe Catalano ,  Giorgio Grioli ,  Vinicio Tincani ,  Antonio Bicchi

IPC: B25J13/08 ,  B25J5/00 ,  B25J9/00 ,  B25J9/16 ,  B25J15/00 ,  B65G47/90 ,  B65G61/00

CPC classification number: B25J9/1682 ,  B25J5/007 ,  B25J9/0087 ,  B25J9/0093 ,  B25J13/08 ,  B25J13/085 ,  B25J15/0009 ,  B25J15/0014 ,  B65G47/907 ,  B65G61/00

Abstract: Logistic device, for handling a package being collected that defines a contact surface with items not being collected, including a first robotic arm including adaptive gripper having at least three degrees of freedom to modify adaptive gripper position and spatial orientation; a second robotic arm including an end effector defining a resting surface and three degrees of freedom to modify end effector position and spatial orientation; control unit to command the first robotic arm to contact the adaptive gripper and package, to deform the adaptive gripper according to adhesion surface between the package and move the package from a storage position wherein the contact surface contacts the items and a collection position wherein the contact surface does not contact the items; the second robotic arm bringing the end effector resting surface into contact with the contact surface; and then the second robotic arm to move the package.

公开(公告)号：US20210123900A1

公开(公告)日：2021-04-29

申请号：US17253790

申请日：2019-06-19

Applicant: UNIVERSITA' DI PISA

Inventor： Giovanni RALLO

IPC: G01N33/24

Abstract: A device for determining the real evapotranspiration of a vegetated surface of a soil includes a porous evaporator, at least one portion of which has resistance to water vapor flow depending on a parameter, the porous evaporator having an upper surface exposed to the atmosphere, a tank of liquid water underlying the porous evaporator to which the tank is connected by a suction tube, and provided with a meter for measuring water level, a sensor for measuring the humidity value of the soil, and a CPU controlling the parameter on which the resistance to the water vapor flow through the porous evaporator depends, depending on the humidity value of the soil detected by the sensor.

公开(公告)号：US20200299306A1

公开(公告)日：2020-09-24

申请号：US16645267

申请日：2018-09-04

Applicant: UNIVERSITA' DI PISA

Inventor： Armando ROSSELLO ,  Elisa NUTI ,  Elisabetta ORLANDINI ,  Susanna NENCETTI ,  Claudia MARTINI ,  Barbara COSTA ,  Chiara GIACOMELLI ,  Simona DANIELE

IPC: C07D501/18 ,  C07D495/04 ,  C07D209/94 ,  C07D513/04 ,  C07D491/052 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of general formula (I), and their use for the treatment and diagnosis of degenerative disorders characterized by high cell proliferation and/or tissue degeneration.