公开(公告)号：US08173665B2

公开(公告)日：2012-05-08

申请号：US12509936

申请日：2009-07-27

Applicant: Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenieh ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenieh ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A01N43/54 ,  A61K31/505

CPC classification number: C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the invention are useful in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.

Abstract translation: 本发明涉及4-氰基苯基，2-硫烷基，1-苯基嘧啶衍生物，其制备方法及其药物组合物。 本发明的化合物和组合物可用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。

公开(公告)号：US07919489B2

公开(公告)日：2011-04-05

申请号：US11894307

申请日：2007-08-20

Applicant: Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Ulrich Rosentreter ,  Martin Hendrix ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke ,  Daniela Paulsen ,  Armin Kern

Inventor： Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Ulrich Rosentreter ,  Martin Hendrix ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke ,  Daniela Paulsen ,  Armin Kern

IPC: A61P31/12 ,  A61K31/4178 ,  A61K31/4164 ,  C07D401/12 ,  C07D233/90

CPC classification number: C07D233/90 ,  C07D401/12

Abstract: The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及杂环基酰胺取代的咪唑及其制备方法，它们用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 作为抗病毒剂，特别是针对巨细胞病毒。

公开(公告)号：US07825255B2

公开(公告)日：2010-11-02

申请号：US10471079

申请日：2002-02-28

Applicant: Ulrich Rosentreter ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stásch

Inventor： Ulrich Rosentreter ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stásch

IPC: C07D401/00 ,  C07D409/00 ,  C07D405/00 ,  C07D213/84 ,  C07D213/72

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14

Abstract: The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.

Abstract translation: 本发明涉及式（I）的化合物，其制备方法及其作为药物的用途。

公开(公告)号：US07504421B2

公开(公告)日：2009-03-17

申请号：US11359927

申请日：2006-02-21

Applicant: Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstatter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

Inventor： Ulrich Rosentreter ,  Rolf Henning ,  Marcus Bauser ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Klaus Dembowsky ,  Olga Salcher-Schraufstatter ,  Johannes-Peter Stasch ,  Thomas Krahn ,  Elisabeth Perzborn

IPC: C07D213/85 ,  A61K31/44

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.

Abstract translation: 本发明涉及通式（I）的化合物，其制备方法及其作为广泛医学指征谱的药理学有效物质的用途。 此外，提供选择性腺苷受体配体，优选选择性腺苷A1-，腺苷A2a-和/或腺苷A2b-受体配体用于预防和/或治疗泌尿生殖区疾病，特别是心血管疾病，泌尿生殖系疾病 呼吸道，炎性和神经炎症性疾病，糖尿病，特别是胰腺糖尿病，神经变性疾病，疼痛状态，癌症以及肝纤维化和肝硬化。

公开(公告)号：US20080269300A1

公开(公告)日：2008-10-30

申请号：US11661820

申请日：2005-08-30

Applicant: Jens-Kerim Erguden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hutter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hubsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

Inventor： Jens-Kerim Erguden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hutter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hubsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

IPC: A61K31/4439 ,  C07D417/12 ,  A61P9/12

CPC classification number: C07D417/12

Abstract: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Abstract translation: 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

公开(公告)号：US20080214654A1

公开(公告)日：2008-09-04

申请号：US11665316

申请日：2005-10-12

Applicant: Thomas Lampe ,  Cristina Alonso-Alija ,  Beatrix Stelte-Ludwig ,  Peter Sandner ,  Marcus Bauser ,  Hartmut Beck ,  Klemens Lustig ,  Ulrich Rosentreter ,  Elke Stahl ,  Hiroko Takagi

Inventor： Thomas Lampe ,  Cristina Alonso-Alija ,  Beatrix Stelte-Ludwig ,  Peter Sandner ,  Marcus Bauser ,  Hartmut Beck ,  Klemens Lustig ,  Ulrich Rosentreter ,  Elke Stahl ,  Hiroko Takagi

IPC: A61K31/381 ,  C07C271/06 ,  A61K31/27 ,  A61K31/164 ,  A61P13/02 ,  C07C237/00 ,  C07D333/02

CPC classification number: C07C233/40 ,  C07C233/36 ,  C07C233/37 ,  C07C233/38 ,  C07C233/62 ,  C07C233/73 ,  C07C233/78 ,  C07C271/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D231/14 ,  C07D333/38

Abstract: The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

Abstract translation: 本发明涉及新的取代的苄氧基 - 苯基甲基甲酰胺衍生物，其制备方法及其在药物中的用途，特别是用于预防和治疗与冷薄荷醇受体1（CMR-1）活性有关的疾病，特别是用于治疗 泌尿系统疾病或障碍，如逼尿肌过度活动症（膀胱过度活动症），尿失禁，神经源性逼尿肌过敏反应（逼尿肌过敏症），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

公开(公告)号：US20070167406A1

公开(公告)日：2007-07-19

申请号：US10525867

申请日：2003-08-18

Applicant: Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schiemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schiemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A61K31/695 ,  C07F7/02 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  C07D413/02 ,  C07D403/02 ,  C07D401/02

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

Abstract: The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

Abstract translation: 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。

公开(公告)号：US20060287315A1

公开(公告)日：2006-12-21

申请号：US11299342

申请日：2005-12-08

Applicant: Susanne Rohrig ,  Mario Jeske ,  Metin Akbaba ,  Ulrich Rosentreter ,  Stephen Boyer ,  Karin Fischer ,  Jens Pohlmann ,  Arounarith Tuch ,  Elisabeth Perzborn ,  Christoph Gerdes ,  Karl-Heinz Schlemmer ,  Nils Burkhardt ,  Swen Allerheiligen ,  Peter Nell ,  Sabine Arndt ,  Mario Lobell

Inventor： Susanne Rohrig ,  Mario Jeske ,  Metin Akbaba ,  Ulrich Rosentreter ,  Stephen Boyer ,  Karin Fischer ,  Jens Pohlmann ,  Arounarith Tuch ,  Elisabeth Perzborn ,  Christoph Gerdes ,  Karl-Heinz Schlemmer ,  Nils Burkhardt ,  Swen Allerheiligen ,  Peter Nell ,  Sabine Arndt ,  Mario Lobell

IPC: A61K31/5377 ,  A61K31/497 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D491/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

Abstract translation: 本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：US20060160801A1

公开(公告)日：2006-07-20

申请号：US10527391

申请日：2003-08-28

Applicant: Heike Gielen-Haertwig ,  Volkhart Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allertheiligen ,  Leila Telan ,  Lars Barfacker ,  Jorg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allertheiligen ,  Leila Telan ,  Lars Barfacker ,  Jorg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A61K31/5377 ,  A61K31/513 ,  C07D413/14 ,  C07D403/14

CPC classification number: C07D239/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

Abstract: The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.

Abstract translation: 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。

公开(公告)号：US06174884B1

公开(公告)日：2001-01-16

申请号：US09367538

申请日：1999-08-16

Applicant: Helmut Haning ,  Ulrich Niewöhner ,  Ulrich Rosentreter ,  Thomas Schenke ,  Jörg Keldenich ,  Erwin Bischoff ,  Karl-Heinz Schlemmer ,  Helmuth Sch{umlaut over (u)}tz ,  G{umlaut over (u)}nter Thomas

Inventor： Helmut Haning ,  Ulrich Niewöhner ,  Ulrich Rosentreter ,  Thomas Schenke ,  Jörg Keldenich ,  Erwin Bischoff ,  Karl-Heinz Schlemmer ,  Helmuth Sch{umlaut over (u)}tz ,  G{umlaut over (u)}nter Thomas

IPC: A61K31519

CPC classification number: C07D487/04

Abstract: The 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives are prepared by fusing the pyrimidone heterocycle with the suitably substituted pyrazoles. The compounds are suitable as active compounds in medicaments, in particular in medicaments for the treatment of cardiovascular and cerebrovascular diseases, diseases of the peripheral blood vessels and diseases of the urogenital tract.

Abstract translation: 1,5-二氢 - 吡唑并[3,4-d]嘧啶酮衍生物是通过将嘧啶酮杂环与适当取代的吡唑进行熔融混合来制备的。 该化合物适合用作药物中的活性化合物，特别是用于治疗心血管和脑血管疾病，外周血管疾病和泌尿生殖道疾病的药物。