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公开(公告)号：US20170326078A1
公开(公告)日：2017-11-16
申请号：US15666128
申请日：2017-08-01
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , UNIVERSIDADE DE SAO PAULO - USP , UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS
发明人： Raphael MECHOULAM , Antonio Waldo ZUARDI , Flavio Pereira KAPCZINSKI , Jaime Eduardo Cecilio HALLAK , Francisco Silveira GUIMARAES , Jose Alexandre de Souza CRIPPA , Aviva BREUER
IPC分类号： A61K31/055 , C07C69/63 , C07C39/42
CPC分类号： A61K31/055 , C07C39/373 , C07C39/42 , C07C69/16 , C07C69/63 , C07C2601/16
摘要： The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
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2.发明申请PHARMACEUTICAL COMPOSTIONS COMPRISING KISSPEPTIN OR DERIVATIVES THEREOF 审中-公开包含KISSPEPTIN或其衍生物的药物组合物公开(公告)号：US20160074320A1
公开(公告)日：2016-03-17
申请号：US14783476
申请日：2014-04-09
IPC分类号： A61K9/00 , A61K47/14 , A61K47/18 , A61K47/12 , A61K47/44 , A61K47/22 , A61K47/34 , A61K47/10 , A61K38/09 , A61K47/26
CPC分类号： A61K9/0019 , A61K9/0024 , A61K38/08 , A61K38/09 , A61K38/17 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/44
摘要： The present invention relates to pharmaceutical compositions comprising a peptide that stimulates the release of gonadotropins and sexual steroids. More specifically, the present invention provides pharmaceutical compositions comprising kisspeptin, preferably in the kp-10 form, or derivatives thereof, for use in ovulation cycle inducing and/or infertility treatment programs. The formulations according to the present invention belong to two main groups: injectable solutions and implantable formulations. The injectable solutions according to the present invention can be divided into immediate release solutions and prolonged action solutions. The implantable formulations according to the present invention can be prepared using an RTV silicone elastomer, a rapid vulcanization silicone elastomer or a rapid vulcanization silicone elastomer with a release modulator.
摘要翻译： 本发明涉及包含刺激促性腺激素和性类固醇释放的肽的药物组合物。 更具体地，本发明提供药物组合物，其包含用于排卵周期诱导和/或不孕症治疗方案中的优选以kp-10形式的kisspeptin或其衍生物。 根据本发明的制剂属于两个主要组：可注射溶液和可植入制剂。 根据本发明的可注射溶液可以分为立即释放溶液和延长的作用溶液。 根据本发明的可植入制剂可以使用RTV硅氧烷弹性体，快速硫化硅氧烷弹性体或具有释放调节剂的快速硫化硅氧烷弹性体来制备。
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公开(公告)号：US20160251561A1
公开(公告)日：2016-09-01
申请号：US15053132
申请日：2016-02-25
发明人： Koiti ARAKI , Sergio Hiroshi TOMA , Delmárcio Gomes DA SILVA , Henrique Eisi TOMA , Rita de Cássia Comis WAGNER , Bernardo Coutinho Camilo DOS SANTOS , Alex Tadeu de Almeida WALDMANN
CPC分类号： C09K8/58 , C01G49/08 , C01P2002/88 , C01P2004/64 , C01P2006/42 , C01P2006/82 , C09K8/035 , C09K2208/10
摘要： This invention describes the development of technology for the preparation of superparamagnetic lipophilic nanofluids, as well as of drilling fluid additives based on the aforementioned nanofluids, which improve the properties which form walls or mud filter cakes and concomitantly act as contrast agents in RMN logging.
摘要翻译： 本发明描述了用于制备超顺磁性亲脂性纳米流体的技术的开发，以及基于上述纳米流体的钻井液添加剂的开发，其改善形成壁或泥浆滤饼的性质，并且伴随地用作RMN测井中的造影剂。
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4.发明申请PROCESS FOR OBTAINING NANOCOMPOSITES, NANOCOMPOSITE, METHOD OF CAPTURE AND RETRIEVAL OF A SOLUBILIZED AND/OR DISPERESED MATERIAL IN ORGANIC OR INORGANIC MEDIUM, METHOD OF PURIFICATION OF AN ORGANIC OR INORGANIC MEDIUM AND CAPTURE AND RETRIEVAL KIT FOR A SOLUBILIZED AND/OR DISPERSED MATERIAL IN ORGANIC OR INORGANIC MEDIUM 审中-公开用于获得有机或无机介质中溶解和/或分散材料的纳米复合材料，纳米复合材料，捕获和/或分离材料的方法，有机或无机介质的净化方法和用于有机和/或分散材料的有机和无机材料的捕获和检索试剂盒 或无机介质公开(公告)号：US20150367324A1
公开(公告)日：2015-12-24
申请号：US14737045
申请日：2015-06-11
发明人： Koiti ARAKI , Ulisses Condomitti EPAMINO , Alceu Totti SILVEIRA JUNIOR , Sergio Hiroshi TOMA , Henrique Eisi TOMA
CPC分类号： B01J20/205 , B01D15/3885 , B01J20/06 , B01J20/28009 , B01J20/28016 , B01J20/305 , B03C1/01 , C02F1/283 , C02F1/288 , C02F1/488 , C02F2101/20 , C02F2101/305 , C02F2101/306 , C02F2101/308 , C02F2103/28 , C02F2103/30 , C02F2103/365 , C02F2305/08
摘要： The present invention lies in the fields of chemistry and nanotechnology and describes a nanocomposite to be used in the recovery of several compounds from inorganic or organic medium. Specifically, the invention presents a nanocomposite consisting of magnetic nanoparticles composed of Fe3O4 associated to an activated charcoal adsorbent substrate, a process to obtain and methods of use of the nanocomposite. The present invention enables the processing, concentration and recovery of large volumes of contaminated water, regenerating magnetic adsorbent material for reuse, in a cyclic and sustainable manner, transforming dispersed/diluted pollutants in pre-concentrates that can be easily processed, helping to conserve natural resources.
摘要翻译： 本发明在于化学和纳米技术领域，并描述了一种用于从无机或有机介质中回收几种化合物的纳米复合材料。 具体地说，本发明提供了一种由与活性炭吸附剂底物相关的Fe 3 O 4组成的磁性纳米粒子，获得的方法和纳米复合材料的使用方法组成的纳米复合材料。 本发明能够以循环和可持续的方式处理，浓缩和回收大量污染的水，再生再生磁性吸附剂材料，将易于加工的预浓缩物中的分散/稀释污染物转化，有助于保护天然 资源。
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公开(公告)号：US20240245738A1
公开(公告)日：2024-07-25
申请号：US17050145
申请日：2019-01-04
发明人： Oswaldo KEITH OKAMOTO , Mayana ZATZ , Carolini KAID DAVILA , Ernesto DA SILVEIRA GOULART GUIMARAES , Luiz CARLOS DE CAIRES JUNIOR
IPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C12N7/00
CPC分类号： A61K35/768 , A61K45/06 , A61P35/00 , C12N7/00 , C12N2770/24132
摘要： A kit is disclosed, for the destruction of cancer cells with stem cell properties based on the oncolytic action of the Zika virus, associated with the aggressiveness of malignant tumors and an unfavorable clinical prognosis, especially in malignant tumors of the nervous system. The kit contains a pharmaceutical composition, sterile glass vials with a rubber seal, and syringes with sterile and disposable needles for injection.
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公开(公告)号：US10441553B2
公开(公告)日：2019-10-15
申请号：US15666128
申请日：2017-08-01
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , UNIVERSIDADE DE SAO PAULO—USP , UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS
发明人： Raphael Mechoulam , Antonio Waldo Zuardi , Flavio Pereira Kapczinski , Jaime Eduardo Cecilio Hallak , Francisco Silveira Guimaraes , Jose Alexandre de Souza Crippa , Aviva Breuer
IPC分类号： A61K31/055 , C07C69/63 , C07C39/42 , C07C69/16 , C07C39/373
摘要： The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
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公开(公告)号：US20170197904A1
公开(公告)日：2017-07-13
申请号：US15241557
申请日：2016-08-19
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , UNIVERSIDADE DE SAO PAULO - USP , UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS
发明人： Raphael MECHOULAM , Antonio Waldo ZUARDI , Flavio Pereira KAPCZINSKI , Jaime Eduardo Cecilio HALLAK , Francisco Silveira GUIMARAES , Jose Alexandre de Souza CRIPPA , Aviva BREUER
CPC分类号： A61K31/055 , C07C39/373 , C07C39/42 , C07C69/16 , C07C69/63 , C07C2601/16
摘要： The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
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公开(公告)号：US09653773B2
公开(公告)日：2017-05-16
申请号：US14395176
申请日：2013-04-24
发明人： Philippe Ferrari , Gustavo Pamplona Rehder , Ariana Serrano , Florence Podevin , Anne-Laure Franc
摘要： The instant disclosure describes a radiofrequency propagation line including a conducting strip connected to a conducting plane parallel to the plane of the conducting strip, wherein the conducting plane includes a network of nanowires made of an electrically conductive, non-magnetic material extending orthogonally to the plane of the conducting strip, in the direction of said conducting strip.
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公开(公告)号：US20150070110A1
公开(公告)日：2015-03-12
申请号：US14395176
申请日：2013-04-24
申请人： Universite Joseph Fourier , Institute Polytechnique de Grenoble , Universidade de Sao Paulo - USP
发明人： Philippe Ferrari , Gustavo Pamplona Rehder , Ariana Serrano , Florence Podevin , Anne-Laure Franc
IPC分类号： H01P3/00
摘要： The instant disclosure describes a radiofrequency propagation line including a conducting strip connected to a conducting plane parallel to the plane of the conducting strip, wherein the conducting plane includes a network of nanowires made of an electrically conductive, non-magnetic material extending orthogonally to the plane of the conducting strip, in the direction of said conducting strip.
摘要翻译： 本公开描述了一种射频传播线，其包括连接到与导电条的平面平行的导电平面的导电条，其中该导电平面包括由与该平面垂直延伸的导电非磁性材料制成的纳米线网络 在导电条的方向上。
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公开(公告)号：US10086358B2
公开(公告)日：2018-10-02
申请号：US14737045
申请日：2015-06-11
发明人： Koiti Araki , Ulisses Condomitti Epamino , Alceu Totti Silveira Junior , Sergio Hiroshi Toma , Henrique Eisi Toma
IPC分类号： B01J20/20 , B03C1/01 , B01J20/06 , B01J20/28 , B01J20/30 , B01D15/38 , C02F1/28 , C02F101/30 , C02F103/30 , C02F103/28 , C02F101/20 , C02F103/36 , C02F1/48
摘要： The present invention lies in the fields of chemistry and nanotechnology and describes a nanocomposite to be used in the recovery of several compounds from inorganic or organic medium. Specifically, the invention presents a nanocomposite consisting of magnetic nanoparticles composed of Fe3O4 associated to an activated charcoal adsorbent substrate, a process to obtain and methods of use of the nanocomposite. The present invention enables the processing, concentration and recovery of large volumes of contaminated water, regenerating magnetic adsorbent material for reuse, in a cyclic and sustainable manner, transforming dispersed/diluted pollutants in pre-concentrates that can be easily processed, helping to conserve natural resources.
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