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公开(公告)号：US20210146319A1
公开(公告)日：2021-05-20
申请号：US16628616
申请日：2018-07-03
发明人： Benoit SCHEID , Adrien DEWANDRE , Youen VITRY
IPC分类号： B01F3/08 , B01F3/04 , B01F13/00 , B01F15/00 , B01F15/02 , B33Y10/00 , B33Y80/00 , B01J13/00 , B01J4/00
摘要： A device for generating bubbles or droplets may include a cavity comprising a first pressurized phase, at least one input capillary of a second phase, and an output capillary coaxially aligned with the at least one input capillary. The opening of the tip of the at least one input capillary has an internal diameter of less than half the internal diameter of the output capillary. The cross section of the cavity may be selected so that, in use, the average speed field in the cavity is quasi-static.
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公开(公告)号：US20200261205A1
公开(公告)日：2020-08-20
申请号：US16866719
申请日：2020-05-05
摘要： An example medical device is disclosed as an expandable stent. The stent includes a tubular scaffold having an inner surface, an outer surface, and a lumen extending therein. The expandable stent also includes a liner disposed within the lumen of the tubular scaffold. Further, the liner is radially spaced from a medial region of the tubular scaffold to define a tissue ingrowth region along an uncovered portion of the medial region. Additionally, the liner extending along the tissue ingrowth region is configured to limit the amount of tissue ingrowth along the medial region of the scaffold.
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公开(公告)号：US20200033347A1
公开(公告)日：2020-01-30
申请号：US16604444
申请日：2018-04-18
发明人： Ahmad Merhi , Anna-Maria Marini
IPC分类号： G01N33/574 , C07K16/28 , C12N15/113 , C12Q1/6886
摘要： The application discloses the use of at least one ammonium transporter as a biomarker and target for proliferative diseases, and related therapeutic or prophylactic agents, kits and methods.
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公开(公告)号：US10329232B2
公开(公告)日：2019-06-25
申请号：US14391651
申请日：2013-03-28
申请人： UNIVERSITE LIBRE DE BRUXELLES (ULB) , CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS , UNIVERSITE DE RENNES 1 , UNIVERSITE PARIS DESCARTES
IPC分类号： C08J7/04 , C07C43/21 , C07C59/72 , C07C205/37 , C07C217/94 , C07C245/20 , C07C43/225 , C07C69/736 , C07D333/50
摘要： A calixarene directly grafted onto the surface of a material, a related grafting process, and certain calixarene intermediates useful for carrying out the grafting process.
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公开(公告)号：US10010702B2
公开(公告)日：2018-07-03
申请号：US15589704
申请日：2017-05-08
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A method of selective catheterism of in a network of conduits of an anatomical structure including inserting a flexible distal end of a guide for catheterism through the network of conduits. An appendage is attached on the distal end of the guide, the appendage includes a channel extending along a longitudinal axis of the guide. A catheter is slid along the catheter until a distal face of the catheter surrounding the guide engages a proximal surface of the appendage. A force oriented in a distal direction is exerted with the catheter on the appendage, which disengages the appendage from the distal end of the guide within the network of conduits. Navigation through the network of conduits is continued with the flexible distal end of the guide once the appendage is removed.
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公开(公告)号：US20160022373A1
公开(公告)日：2016-01-28
申请号：US14377443
申请日：2013-04-02
发明人： Jean-Baptiste VALSAMIS , Nicolas CAUCHE , Jacques DEVIERE , Christophe CAUCHETEUR , Valerie VOISIN
IPC分类号： A61B19/00
CPC分类号： A61B90/06 , A61B5/22 , A61B5/6852 , A61B5/6885 , A61B34/20 , A61B2034/2061 , A61B2090/064 , A61B2562/0266 , G01B11/18 , G01D5/353 , G01D5/35377 , G01L1/246 , G01L5/166
摘要： Force transducer (10) include two structural members (11, 12) spaced apart to define a gap (101) and being linked to each other. Optical fibres (13) are to the members and are freely suspended in the gap. The optical fibres are configured to provide a change in a detectable optical property responsive to a change in relative position between the two members in one or more predetermined degrees of freedom. Each of the optical fibres (13) is fixed to both structural members and continuous between the members to link the two structural members to each other. The optical fibres are substantially the only structure forming a link between the two structural members (11, 12), such that the arrangement of the optical fibres defines substantially the stiffness of the link between the two structural members in the one or more predetermined degrees of freedom, which stiffness is mainly, such as for at least 95%, determined by the optical fibres.
摘要翻译： 力传感器（10）包括间隔开以限定间隙（101）并彼此连接的两个结构构件（11,12）。 光纤（13）连接到构件上并且自由地悬挂在间隙中。 光纤被配置为响应于在一个或多个预定自由度中两个构件之间的相对位置的变化而提供可检测光学特性的变化。 每个光纤（13）被固定到两个结构构件并且连接在构件之间以将两个结构构件彼此连接。 光纤基本上是形成两个结构构件（11,12）之间的连接的唯一结构，使得光纤的布置基本上在两个结构构件之间的连接的刚度在一个或多个预定的程度 自由度，其刚度主要由光纤确定，例如至少95％。
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公开(公告)号：US20150132590A1
公开(公告)日：2015-05-14
申请号：US14399365
申请日：2013-05-07
发明人： Iris De Graeve , Herman Terryn , François Reniers , Caroline De Vos , Alexandros Kakaroglou , Bernard Nisol , Bruno Van Mele , Guy Van Assche , Gill Scheltjens
CPC分类号： C23F11/02 , B05D1/62 , B05D7/14 , B05D2202/25 , B05D2490/50 , C23F13/005 , C23F13/02 , Y10T428/31678
摘要： The present invention is related to a method for protecting a metal substrate against corrosion comprising the step of: —generating a plasma in a gaseous medium by means of a plasma device; —placing the substrate in contact with the plasma, or in a post-plasma area of said plasma; —introducing in said plasma or in said post-plasma area a corrosion inhibitor along with an organic precursor, thereby depositing a barrier layer comprising the corrosion inhibitor, the deposited layer protecting the metal substrate against corrosion.
摘要翻译： 本发明涉及一种用于保护金属基材免受腐蚀的方法，包括以下步骤： - 通过等离子体装置在气态介质中产生等离子体; 使衬底与等离子体接触，或在所述等离子体的后等离子体区域中; - 在所述等离子体或所述后等离子体区域中引入腐蚀抑制剂以及有机前体，从而沉积包含所述腐蚀抑制剂的阻挡层，所述沉积层保护所述金属基底免受腐蚀。
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公开(公告)号：US20150089230A1
公开(公告)日：2015-03-26
申请号：US14562308
申请日：2014-12-05
IPC分类号： H04L29/06
CPC分类号： H04L63/0876 , G06F21/606 , H04L9/0825 , H04L9/0869 , H04L9/3242 , H04L63/123
摘要： A computer device includes means for receiving a request for at least one random number; means for generating a message authentication code from the identifier and at least one random number to be transmitted; and means for creating a message for transmission, including the random number in plain text and the message authentication code. A random number distribution system includes the computer device; a communication network; and a receiver device connectable to the computer device via the network to transmit requests for random numbers to the computer device and to receive messages from the computer device.
摘要翻译： 计算机设备包括用于接收对至少一个随机数的请求的装置; 用于从所述标识符和要发送的至少一个随机数生成消息认证码的装置; 以及用于创建用于传输的消息的装置，包括明文中的随机数和消息认证码。 随机数分配系统包括计算机设备; 通讯网络 以及经由网络可连接到计算机设备的接收机设备，以向计算机设备发送用于随机数的请求并从计算机设备接收消息。
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公开(公告)号：US20140186955A1
公开(公告)日：2014-07-03
申请号：US14072025
申请日：2013-11-05
发明人： Pierre Vanderhaeghen , Nicolas Gaspard , Gilles Naeije , Jelle Van Den Ameele , Fabienne Devreker , Yvon Englert
IPC分类号： C12N5/0793 , C12N5/0797
CPC分类号： C12N5/0619 , C12N5/0623 , C12N2500/25 , C12N2500/90 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.
摘要翻译： 本发明涉及用于将哺乳动物多能干细胞分化为显示神经元表型的细胞的体外方法，更具体地涉及包括特别是锥体神经元和皮质抑制性中间神经元的皮层型神经元。 本发明还包括如此获得的神经元细胞和细胞群，包含此类物质的组合物，以及所述神经细胞和细胞群体的进一步用途。
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10.发明申请METHOD AND KIT FOR THE DETECTION OF GENES ASSOCIATED WITH PIK3CA MUTATION AND INVOLVED IN PI3K/AKT PATHWAY ACTIVATION IN THE ER-POSTITIVE AND HER2-POSITIVE SUBTYPES WITH CLINICAL IMPLICATIONS 审中-公开检测与PIK3CA突变相关基因并参与PI3K / AKT途径激活在具有临床意义的ER阳性和HER2阳性亚型中的基因的方法和试剂盒公开(公告)号：US20140056881A1
公开(公告)日：2014-02-27
申请号：US14032984
申请日：2013-09-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour, the said method comprising the step of assaying a sample of a breast tumour from said patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.
摘要翻译： 一种确定影响患者的乳腺肿瘤的临床结果的方法，所述乳腺肿瘤如果用针对乳腺肿瘤的抗肿瘤剂治疗，则所述方法包括通过接触从所述患者测定乳腺肿瘤样品中所选基因的表达水平的步骤 来自该乳腺肿瘤的细胞的mRNA序列与一组与人突变的PIK3CA相关的3个以上的核苷酸序列。
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