公开(公告)号：US20240342496A1

公开(公告)日：2024-10-17

申请号：US18659762

申请日：2024-05-09

申请人： University of Connecticut

发明人： Ki Chon ,  Mahdi Pirayesh Shirazi Nejad

IPC分类号： A61N1/39

CPC分类号： A61N1/395 ,  A61N1/3987 ,  G06N3/045 ,  G06N3/0464

摘要： An apparatus for treating a person having cardiac arrest includes a processor and a lead in communication with the processor, the lead being configured to receive a segment of electrocardiogram (ECG) data from the person while undergoing cardiopulmonary resuscitation (CPR). The apparatus also includes a non-transitory computer-readable medium having: a first Convolutional Neural Network-based Encoder-Decoder (CNNED) structure to reduce artifacts due to the CPR; a second CNNED structure cascaded with the first CNNED structure to further reduce artifacts; and instructions to determine a first arrhythmia classification using the first CNNED structure, determine a second arrhythmia classification using the second CNNED structure in response to the first arrhythmia classification indicating a shockable arrhythmia event; and transmit a signal to apply a defibrillation shock to the person in response to the first arrhythmia classification and the second arrhythmia classification indicating a shockable arrhythmia of the person.

公开(公告)号：US20240336833A1

公开(公告)日：2024-10-10

申请号：US18627866

申请日：2024-04-05

申请人： UNIVERSITY OF CONNECTICUT

发明人： Gregory Allen Sotzing

IPC分类号： C09K9/02 ,  C08J5/18 ,  C09D5/08 ,  C09D123/02 ,  C09D167/02 ,  C09D175/04 ,  G02F1/1516 ,  H01G4/14 ,  H01G4/33

CPC分类号： C09K9/02 ,  C08J5/18 ,  C09D5/08 ,  C09D123/02 ,  C09D167/02 ,  C09D175/04 ,  G02F1/15165 ,  H01G4/14 ,  H01G4/33 ,  C08J2367/02

摘要： Disclosed herein are polycannabinoids and polycannabinoid compositions which find use as a commodity polymer and for commodity electronics. Suitable uses include coatings and paints. Polycannabinoids can be used as polymer dielectrics for capacitors and capacitive energy storage. Also disclosed are new electrochromic materials comprising polycannabinoids and a salt. Further disclosed are electrochromic devices prepared from the electrochromic materials and electrochromic material compositions.

公开(公告)号：US12103950B2

公开(公告)日：2024-10-01

申请号：US18159906

申请日：2023-01-26

申请人： UNIVERSITY OF CONNECTICUT

发明人： Gerald Berkowitz ,  Samuel Haiden ,  Yi Ma

IPC分类号： C07K14/415 ,  C12N15/82

CPC分类号： C07K14/415 ,  C12N15/8223 ,  C12N15/8243

摘要： The present disclosure provides compositions and methods related to genetically engineered plants. In particular, the present disclosure provides novel compositions for transgenic cannabis plants that overexpress a R2R3-MYB transcription factor gene and methods related to the genetic regulation of the development of a glandular trichome in plants.

公开(公告)号：US12064759B2

公开(公告)日：2024-08-20

申请号：US17245381

申请日：2021-04-30

申请人： NUtech Ventures ,  UNIVERSITY OF CONNECTICUT

发明人： Ruiguo Yang ,  Arian Jaberi ,  Amir Monemian Esfahani ,  Ali Tamayol

IPC分类号： B01L3/00 ,  C12M1/34 ,  C12N1/34

CPC分类号： B01L3/5025 ,  C12M41/46 ,  C12N1/34 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  C12N2513/00

摘要： Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.

公开(公告)号：US12060555B2

公开(公告)日：2024-08-13

申请号：US17663378

申请日：2022-05-13

申请人： Yale University ,  University of Connecticut

发明人： Farida Ahangari ,  Naftali Kaminski ,  Carlos Fernandez-Hernando ,  Raman Bahal

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P9/10 ,  C12N15/11

CPC分类号： C12N15/111 ,  A61K31/713 ,  A61P9/10 ,  C12N15/113

摘要： In one aspect, the present disclosure provides a microRNA-33 (miR-33) inhibitor comprising a peptide nucleic acid covalently bound to a pH low insertion peptide. In another aspect, the present disclosure provides a method of treating pulmonary fibrosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the miR-33 inhibitor. In some embodiments, the pulmonary fibrosis is idiopathic pulmonary fibrosis.

公开(公告)号：US20240207358A1

公开(公告)日：2024-06-27

申请号：US18288244

申请日：2022-05-10

申请人： University of Connecticut

发明人： LIPING XIAO ,  Marja HURLEY ,  Tannin SCHMIDT

IPC分类号： A61K38/17 ,  A61P7/06

CPC分类号： A61K38/1709 ,  A61P7/06

摘要： The present disclosure is directed to administration of native or recombinant human PRG4 (rhPRG4) as a means to treat sickle cell disease or other disorders in subjects in need of treatment thereof.

公开(公告)号：US12011878B2

公开(公告)日：2024-06-18

申请号：US17570431

申请日：2022-01-07

申请人： University Of Connecticut

发明人： Ali Tamayol ,  Mohamadmahdi Samandari ,  Jacob Quint

IPC分类号： B29C64/336 ,  B29C48/02 ,  B29C64/118 ,  B29C64/209 ,  B33Y10/00 ,  B33Y30/00

CPC分类号： B29C64/336 ,  B29C48/02 ,  B29C64/118 ,  B29C64/209 ,  B33Y10/00 ,  B33Y30/00

摘要： A multi-material printer can include a housing that is configured to be handheld. The housing can be configured to receive first and second printable materials from respective first and second containers. A nozzle can define an outlet of the multi-material printer. At least one actuator can be configured to cause first and second printable materials from the first and second containers to flow at a respective constant rate. The multi-material printer can be configured to simultaneously extrude the first and second printable materials from the outlet. The multi-material printer can be used for fabricating a scaffold from filaments comprising the first and second materials directly within the body of a human or animal.

公开(公告)号：US20240082167A1

公开(公告)日：2024-03-14

申请号：US18262443

申请日：2022-01-21

申请人： UNIVERSITY OF CONNECTICUT

发明人： Cato LAURENCIN ,  Shiv S. SHAH ,  Lakshmi NAIR ,  Ho-man KAN

IPC分类号： A61K9/50 ,  A61K9/19 ,  A61K38/18 ,  A61K45/06 ,  A61P19/02

CPC分类号： A61K9/5031 ,  A61K9/19 ,  A61K38/1825 ,  A61K38/1841 ,  A61K45/06 ,  A61P19/02

摘要： This disclosure relates to an engineered a novel synthetic artificial stem cell (SASC) system which mimics the paracrine effect of the stem cell secretome and provides tailorability of the composition for targeted tissue regeneration. This novel SASC system demonstrates the feasibility of developing a completely synthetic, tailorable stem cell secretome which reinforces the possibility of developing a new therapeutic strategy that provides better control over targeted tissue engineering applications. Disclosed herein are biodegradable polymeric microspheres that have been used to encapsulate secretome active agents. These microspheres mimic or have the potential to result in a greater therapeutic paracrine effect compared to stem cells, without the added risk of immunological response or the extra pro-inflammatory, antagonistic or inert factors/cytokines. The compositions may be personalized to any disease and/or individual, therefore, adding a much needed element to therapeutics.

公开(公告)号：US20240067911A1

公开(公告)日：2024-02-29

申请号：US18364999

申请日：2023-08-03

申请人： University of Connecticut

发明人： Mu-Ping Nieh ,  Armin Tahmasbi Rad ,  Reza Amin ,  Leila Daneshmandi

IPC分类号： C12M3/06 ,  C12N5/00 ,  G01N33/50 ,  C12M1/34 ,  C12M1/12

CPC分类号： C12M23/16 ,  C12N5/0012 ,  G01N33/5008 ,  C12M41/46 ,  C12M25/16

摘要： Described herein are apparati and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.

公开(公告)号：US20240061735A1

公开(公告)日：2024-02-22

申请号：US18450305

申请日：2023-08-15

申请人： University of Connecticut

发明人： Peter Watson ,  Emmanouil Anagnostou ,  Diego Cerrai ,  Wei Zhang ,  William Hughes ,  William Taylor ,  Amvrossios Bagtzoglou

IPC分类号： G06F11/00

CPC分类号： G06F11/004 ,  G06F2201/81

摘要： Systems and methods for assessing the resilience of an infrastructural system. The system includes a computer program product stored on non-transitory machine-readable media. The media includes machine executable instructions for implementing a method for assessing the resilience of an infrastructural system. The method includes receiving, from an interface, scenario specific data regarding conditions for the infrastructural system; processing the scenario specific data to determine a vulnerability metric for a probability of failure for a component of the infrastructural system; determining, based on the vulnerability metric, an in-situ failure risk of the infrastructural system incorporating a complexity of environmental conditions; determining, based on the vulnerability metric, a recommended maintenance task for the component of the infrastructural system; and providing the in-situ failure risk of the infrastructural system and the recommended maintenance task for the component to the interface.