公开(公告)号：US11021721B2

公开(公告)日：2021-06-01

申请号：US16041371

申请日：2018-07-20

申请人： Alliance for Sustainable Energy, LLC ,  Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen ,  University of Stuttgart

发明人： Gregg Tyler Beckham ,  Mary Ann Franden ,  Lahiru N. Jayakody ,  Nick Johannes Petrus Wierckx ,  Janosch Alexander Klebensberger ,  Lars Mathias Blank ,  Wing-Jin Li ,  Bernhard Hauer ,  Nicholas S. Cleveland ,  William E. Michener ,  Jason Michael Whitham

IPC分类号： C12P7/62 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12N15/52

摘要： Presented herein are genetically engineered Pseudomonas strains capable of metabolizing ethylene glycol and producing polyhydroxyalkanoates.

公开(公告)号：US20030175910A1

公开(公告)日：2003-09-18

申请号：US10334990

申请日：2003-01-02

申请人： University of Stuttgart

发明人： Josef Altenbuchner ,  Andreas Bommarius ,  Ralf Mattes ,  Christoph Syldatk ,  Wilhelm Tischer ,  Anja Wiese ,  Burkard Wilms

IPC分类号： C12P013/04 ,  C12N009/80 ,  C12N001/21

CPC分类号： C12P13/227 ,  C12N9/80 ,  C12N9/86 ,  C12N9/90 ,  C12P41/009 ,  C12Y305/02002

摘要： A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process for the production of this catalysts and for the production of amino acids is claimed.

摘要翻译： 描述了包含乙内酰脲酶，消旋酶和氨基甲酰化酶的全细胞催化剂。 因此，该催化剂能够将乙内酰脲直接降解成氨基酸。 另外，要求生产该催化剂和用于生产氨基酸的方法。

公开(公告)号：US20230399672A1

公开(公告)日：2023-12-14

申请号：US18034120

申请日：2021-11-02

申请人： University of Stuttgart ,  MANUS BIO INC.

发明人： Martin ZIEGLER ,  Ralf TAKORS ,  Joana SIEMEN ,  Michael LÖFFLER ,  Christine Nicole S. SANTOS ,  Ajikumar Parayil KUMARAN

IPC分类号： C12P21/02 ,  C12N15/52 ,  C12N15/70 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/90

CPC分类号： C12P21/02 ,  C12N15/52 ,  C12N15/70 ,  C12N9/0008 ,  C12Y102/07001 ,  C12N9/1051 ,  C12Y204/01 ,  C12N9/1205 ,  C12Y207/01002 ,  C12Y207/01032 ,  C12N9/90 ,  C12Y504/99009

摘要： The present invention in various aspects and embodiments provides engineered bacterial strains having a modified genome that provides advantages in maintenance and biosynthetic processes when cultured at large scale. The present invention further provides methods for large-scale fermentation using the bacterial strains. In various embodiments, the strain engineering yields a reduction in cellular responses to micro-environmental stimuli imposed in large scale bioreactors.

公开(公告)号：US20190024126A1

公开(公告)日：2019-01-24

申请号：US16041371

申请日：2018-07-20

申请人： Alliance for Sustainable Energy, LLC ,  Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen ,  University of Stuttgart

发明人： Gregg Tyler BECKHAM ,  Mary Ann FRANDEN ,  Lahiru N. JAYAKODY ,  Nick Johannes Petrus WIERCKX ,  Janosch Alexander KLEBENSBERGER ,  Lars Mathias BLANK ,  Wing-Jin LI ,  Bernhard HAUER ,  Nicholas S. CLEVELAND ,  William E. MICHENER

IPC分类号： C12P7/62 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10

摘要： Presented herein are genetically engineered Pseudomonas strains capable of metabolizing ethylene glycol and producing polyhydroxyalkanoates.