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公开(公告)号：US20230001000A1
公开(公告)日：2023-01-05
申请号：US17827700
申请日：2022-05-28
摘要： Provided herein is an inhibitor compound targeting Hip1, with the inhibitor compound comprising a tripeptide targeting sequence that directs the compound to the active site of Hip1 and a C-terminal electrophilic warhead conjugated to the targeting sequence, the warhead configured to inactive the enzyme.
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公开(公告)号：US20200164240A1
公开(公告)日：2020-05-28
申请号：US16778568
申请日：2020-01-31
发明人： David Harding , Reed Rieske , Gary Kilgore , David Owens , Raleigh Bunch , Charles Tandy , Charles Querry , Hugh Conner , Rickey Hathaway
IPC分类号： A62C99/00 , B60G11/27 , B60G17/015 , B60G17/017
摘要： A transportable fire training apparatus includes a trailer frame having a rear raised section at a rear end of the trailer frame and an unraised section at a middle portion of the trailer frame, a shell attached to the trailer frame and partitioned into a plurality of training rooms, a rear multi-axle wheel set disposed below, and attached to, the rear raised section of the trailer frame via an air ride suspension system that raises the trailer frame relative to the a rear multi-axle wheel set in response to pressurization of the air ride suspension system. The unraised section of the trailer frame rides substantially above the ground when the air ride suspension system is in a pressurized state and rests on the ground when the air ride suspension system is in an unpressurized state. A method for deploying and using the transportable fire training apparatus is also disclosed herein.
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公开(公告)号：US10646621B2
公开(公告)日：2020-05-12
申请号：US15132080
申请日：2016-04-18
IPC分类号： A61L31/10 , A61N1/05 , A61B5/1473 , A61B10/02 , A61B5/0478 , A61F2/04 , A61F2/38 , A61F13/00 , A61L31/16 , A61M25/00 , A61N1/362 , C23C14/22 , A61B17/00 , A61B5/1486 , A61F2/30 , A61B17/14 , A61B17/16 , A61B17/28 , A61B17/3201 , A61B17/3211 , A61M5/142 , A61M5/32
摘要： An apparatus is disclosed for a biofunctional molecular imprint apparatus comprising a supportive structure that cuts, punctures, retains, repairs, protects, interrogates, and/or supports the function of a body tissue or other substance; a surface material that receives and retains a molecular imprint and that is positioned to contact the body tissue or other substance during use; and a molecular imprint of a bioactive molecule that influences blood coagulation, tissue damage, pain, immune response, inflammation, infection, healing, tissue regeneration, cell adhesion, the formation of extracellular matrix, tumorigenesis, angiogenesis, bacterial growth, and/or side effects.
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公开(公告)号：US20170299327A1
公开(公告)日：2017-10-19
申请号：US15291957
申请日：2016-10-12
发明人： Ryan Albrecht
IPC分类号： F41C27/00
CPC分类号： F41C27/00
摘要： In one example, an apparatus for mounting accessories on a rifle includes a base that is mountable to a rifle, an accessory mounting bracket that is L-shaped, the accessory mounting bracket comprising an accessory mounting leg and a depth positioning leg. The depth positioning leg may include a plurality of attachment features disposed along a length thereof that enable attaching the depth positioning leg to the base at a plurality of depth positions. The accessory mounting leg may include a slot for mounting a photographic device at any lateral position within a lateral positioning range (e.g., 3 inches). In some embodiments, the base is mountable to both the left side and the right side of the rifle and the accessory mounting bracket is attachable to the base (on either side of the rifle) at each depth position for any of four orientations.
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公开(公告)号：US09297208B2
公开(公告)日：2016-03-29
申请号：US13692901
申请日：2012-12-03
发明人： Sheldon Hansen
摘要： Exemplary drill tools for placement in a drill string may include a body; a plurality of reamer cutters; and a plurality of ball and socket connectors configured to attach the plurality of reamer cutters to the body. Each of the plurality of reamer cutters may be replaceable by removing at least one of the plurality of ball and socket connectors from the reamer body. Each of the ball and socket connectors may be attached to the reamer body with bolts. Each of the ball and socket connectors may include titanium dioxide and/or titanium carbide coatings where the connectors interface with the reamer cutters.
摘要翻译： 用于放置在钻柱中的示例性钻具可以包括主体; 多个铰刀切割机; 以及多个球窝连接器，其构造成将多个铰刀切割器附接到主体。 多个铰刀切割器中的每一个可以通过从铰刀主体中移除多个球和插座连接器中的至少一个来替换。 每个球窝连接器可以用螺栓连接到铰刀体上。 每个球和插座连接器可以包括二氧化钛和/或碳化钛涂层，其中连接器与铰刀切割器相连接。
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公开(公告)号：US20210387143A1
公开(公告)日：2021-12-16
申请号：US17021874
申请日：2020-09-15
发明人： Timothy Edwin Doyle
IPC分类号： B01D53/85 , G01N33/569
摘要： Disclosed herein is a molecular imprinted air filter for removing, detecting and/or reporting specific agents and/or molecules and comprising one or more air-permeable layers of molecular imprinted material positioned to contact molecules and/or agents in an airborne, and/or microdroplet-borne environment, a bioactive molecular imprint of a molecule that captures a specific airborne, fluid borne, and/or microdroplet-borne molecule, particle, or agent, and an electronic enhancement.
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公开(公告)号：US10955386B2
公开(公告)日：2021-03-23
申请号：US16122707
申请日：2018-09-05
发明人： Timothy E. Doyle , Huda A. Al-Ghaib
摘要： An apparatus includes an XY scanning mechanism, a first transducer configured to transmit a sound wave, a second transducer configured to receive the sound wave, and a tray configured to hold a material. The tray is coupled to the XY scanning mechanism and located beneath the first transducer and the second transducer is located on a bottom side of the tray below the material. The tray is moved in an XY pattern along an X axis and a Y axis in response to an XY scanning mechanism controller mechanically moving the XY scanning mechanism while the first transducer is positioned in a stationary location along a vertical axis perpendicular to the tray. The first transducer transmits sound waves into the material and the second transmitter receives the transmitted sound waves at each XY position.
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公开(公告)号：US10851511B2
公开(公告)日：2020-12-01
申请号：US16119396
申请日：2018-08-31
发明人： Kevin Shurtleff
IPC分类号： E02B15/10 , A01D44/00 , C02F1/40 , C02F1/00 , B01D39/18 , B01D25/12 , B01D24/00 , B01D25/38 , B01D24/46 , B01D39/20 , B01D37/02 , B01D24/12 , C10L1/02 , E02B15/04 , B63B35/32 , C02F101/30 , C02F103/00 , C02F103/08
摘要： A mobile microalgae harvesting apparatus is disclosed. In one embodiment the mobile microalgae harvesting apparatus includes a harvesting boom coupled to a harvesting vessel, where the harvesting boom skims a microalgae mixture of microalgae and water from a surface of a body of water down to a predetermined depth below the surface. In the embodiment, the mobile microalgae harvesting apparatus also includes a separator aboard the harvesting vessel that separates water from the microalgae mixture and a microalgae collector that collects microalgae from the separator, wherein the microalgae collector deposits the collected microalgae on a transfer vessel coupled to the harvesting vessel. A mobile microalgae harvester and a system for harvesting microalgae are also disclosed.
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公开(公告)号：US20200261628A1
公开(公告)日：2020-08-20
申请号：US16869880
申请日：2020-05-08
IPC分类号： A61L31/10 , A61N1/05 , A61B5/1473 , A61B10/02 , A61B5/0478 , A61F2/04 , A61F2/38 , A61F13/00 , A61L31/16 , A61M25/00 , A61N1/362 , C23C14/22
摘要： An apparatus and method are disclosed for a biofunctional molecular imprint medical device configured to remain in permanent or temporary contact with a body comprising a supportive structure, a surface material that receives and retains a molecular imprint and that is positioned to contact a body tissue or other substance during use, a molecular imprint of a bioactive molecule wherein an imprinted cavity is of a bioactive molecule that catalyzes the promotion or suppression biological processes and at least one of a semiconductor, a nanoparticle quantum dot, a nano-island, and a quantum wire, wherein the nanoparticle quantum dot, nano-island, or quantum wire produces an electron wave function configuration that dynamically reconfigures the electron charge distribution within the molecular imprint, enabling tuning of the imprinted cavity.
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公开(公告)号：US20190122576A1
公开(公告)日：2019-04-25
申请号：US16167285
申请日：2018-10-22
IPC分类号： G09B19/00 , A63F13/46 , A63F13/798
摘要： Apparatuses, methods, systems, and program products are disclosed for nanotechnology fabrication in a virtual reality environment. An apparatus includes a simulation module configured to generate a virtual reality environment for simulating a nanotechnology fabrication line. An apparatus includes a task module configured to provide one or more tasks associated with nanotechnology fabrication for a user to complete during a simulation within a virtual reality environment. An apparatus includes an assessment module configured to assess a user's performance while completing one or more tasks during a simulation within a virtual reality environment.
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