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公开(公告)号：US20090215051A1
公开(公告)日：2009-08-27
申请号：US12065258
申请日：2006-08-30
CPC分类号： C12N15/62 , C07K14/43595 , C07K2319/60 , C12N15/10
摘要： The invention relates to a translational recoding reporter construct comprising: a first fluorescent protein coding sequence; a second fluorescent protein coding sequence encoding a fluorescent protein different from the first fluorescent protein; and a linker sequence interposed between the first and second fluorescent protein coding sequence; wherein the a first fluorescent protein coding sequence and the second fluorescent protein coding sequence are out-of-frame with respect to each other but are co-expressed as a single fusion polypetpdie upon recoding. The invention also relates to methods of use of the construct in screening modulators of recoding.
摘要翻译： 本发明涉及翻译记录报告基因构建体，其包含：第一荧光蛋白编码序列; 编码与第一荧光蛋白不同的荧光蛋白的第二荧光蛋白编码序列; 以及置于第一和第二荧光蛋白编码序列之间的接头序列; 其中所述第一荧光蛋白编码序列和所述第二荧光蛋白编码序列相对于彼此不在框架内，但在重新编码时共同表达为单一融合多聚体。 本发明还涉及在筛选调节剂中使用该构建体的方法。
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公开(公告)号：US20070088767A1
公开(公告)日：2007-04-19
申请号：US11549401
申请日：2006-10-13
IPC分类号： G06F17/30
CPC分类号： G06F11/1435 , G06F11/1448 , G06F11/1451 , G06F11/1456 , G06F11/1469 , G06F2201/84 , Y10S707/99955
摘要： A technique for remapping data in a storage management system is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for remapping data in a storage management system having backup data that enable restoration of historical data of a storage system. The method may comprise receiving at least one access request for a first set of historical data. The method may also comprise identifying a second set of historical data, wherein the first set of historical data is a subset of the second set of historical data. The method may further comprise identifying, in the storage management system, one or more storage locations containing backup data for the second set of historical data. The method may additionally comprise storing a mapping list of the one or more identified storage locations to facilitate subsequent access requests for any of the second set of historical data.
摘要翻译： 公开了一种用于在存储管理系统中重新映射数据的技术。 在一个特定示例性实施例中，该技术可以被实现为用于在具有能够恢复存储系统的历史数据的备份数据的存储管理系统中重新映射数据的方法。 该方法可以包括接收对第一组历史数据的至少一个访问请求。 该方法还可以包括识别第二组历史数据，其中第一组历史数据是第二组历史数据的子集。 该方法还可以包括在存储管理系统中识别包含第二组历史数据的备份数据的一个或多个存储位置。 该方法可以另外包括存储一个或多个所识别的存储位置的映射列表，以便于对第二组历史数据中的任何一个的后续访问请求。
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公开(公告)号：US08389236B2
公开(公告)日：2013-03-05
申请号：US12065258
申请日：2006-08-30
CPC分类号： C12N15/62 , C07K14/43595 , C07K2319/60 , C12N15/10
摘要： The invention relates to a translational recoding reporter construct comprising: a first fluorescent protein coding sequence; a second fluorescent protein coding sequence encoding a fluorescent protein different from the first fluorescent protein; and a linker sequence interposed between the first and second fluorescent protein coding sequence; wherein the first fluorescent protein coding sequence and the second fluorescent protein coding sequence are out-of-frame with respect to each other but are co-expressed as a single fusion polypeptide upon recoding. The invention also relates to methods of use of the construct in screening modulators of recoding.
摘要翻译： 本发明涉及翻译记录报告基因构建体，其包含：第一荧光蛋白编码序列; 编码与第一荧光蛋白不同的荧光蛋白的第二荧光蛋白编码序列; 以及置于第一和第二荧光蛋白编码序列之间的接头序列; 其中所述第一荧光蛋白编码序列和所述第二荧光蛋白编码序列相对于彼此超帧，但在重新编码时共表达为单一融合多肽。 本发明还涉及在筛选调节剂中使用该构建体的方法。
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公开(公告)号：US06843145B2
公开(公告)日：2005-01-18
申请号：US10389481
申请日：2003-03-14
摘要： A cardiac phantom is provided for simulating a dynamic cardiac ventricle. The phantom comprises two concentrically-disposed, fluid-tight, flexible membranes defining a closed space between the walls of the membranes. A pump is operatively connected to the inner membrane for reciprocally delivering a volume of fluid to the inner membrane to inflate and deflate both membranes in simulating systole and diastole of a heart. A medium is disposed within the closed space defined between the walls of the membranes for maintaining a uniform distance between the walls of the membranes during inflation and deflation. The phantom is provided for evaluation of medical imaging systems. A method, computer system and a computer-readable medium are also provided for controlling the phantom.
摘要翻译： 提供了用于模拟动态心室的心脏体模。 该幻影包括两个同心设置的，流体密封的柔性膜，其限定了膜壁之间的封闭空间。 泵可操作地连接到内膜，用于相互地将一定体积的流体输送到内膜，以在模拟心脏的收缩和舒张期期间使两个膜膨胀和放气。 介质被布置在限定在膜的壁之间的封闭空间内，用于在充气和放气期间保持膜的壁之间的均匀距离。 提供幻影用于评估医学成像系统。 还提供了一种方法，计算机系统和计算机可读介质来控制幻影。
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公开(公告)号：US06629469B2
公开(公告)日：2003-10-07
申请号：US09874582
申请日：2001-06-05
IPC分类号： G01M1900
摘要： A cardiac phantom is provided for simulating a dynamic cardiac ventricle. The phantom comprises two concentrically-disposed, fluid-tight, flexible membranes defining a closed space between the walls of the membranes. A pump is operatively connected to the inner membrane for reciprocally delivering a volume of fluid to the inner membrane to inflate and deflate both membranes in simulating systole and diastole of a heart. A medium is disposed within the closed space defined between the walls of the membranes for maintaining a uniform distance between the walls of the membranes during inflation and deflation. The phantom is provided for evaluation of medical imaging systems. A method, computer system and a computer-readable medium are also provided for controlling the phantom.
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6.发明授权Technique for improving scalability and portability of a storage management system 有权提高存储管理系统的可扩展性和可移植性的技术公开(公告)号：US07634497B2
公开(公告)日：2009-12-15
申请号：US11549416
申请日：2006-10-13
申请人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
发明人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
IPC分类号： G06F17/00
CPC分类号： G06F11/1435 , G06F3/0607 , G06F3/0632 , G06F3/0634 , G06F3/067 , G06F11/1458 , Y10S707/99943
摘要： A technique for improving scalability and portability of a storage management system is disclosed. In one particular exemplary embodiment, the technique may be realized as a storage management system operatively coupled to a storage system. The storage management system may comprise a plurality of processor modules, wherein each processor module is capable of intercepting write commands directed to the storage system, backing up data associated with the write commands, and generating metadata having timestamps for the backup data. The storage management system may also comprise one or more indexing modules that create one or more indexing tables for the backup data based on the metadata, wherein the one or more indexing modules are in communication with the processor modules and the storage system.
摘要翻译： 公开了一种用于提高存储管理系统的可扩展性和便携性的技术。 在一个特定的示例性实施例中，该技术可以被实现为可操作地耦合到存储系统的存储管理系统。 存储管理系统可以包括多个处理器模块，其中每个处理器模块能够拦截指向存储系统的写入命令，备份与写入命令相关联的数据，以及生成具有备份数据的时间戳的元数据。 存储管理系统还可以包括一个或多个索引模块，其基于元数据为备份数据创建一个或多个索引表，其中一个或多个索引模块与处理器模块和存储系统通信。
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公开(公告)号：US07610320B2
公开(公告)日：2009-10-27
申请号：US11549401
申请日：2006-10-13
申请人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
发明人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
IPC分类号： G06F17/30
CPC分类号： G06F11/1435 , G06F11/1448 , G06F11/1451 , G06F11/1456 , G06F11/1469 , G06F2201/84 , Y10S707/99955
摘要： A technique for remapping data in a storage management system is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for remapping data in a storage management system having backup data that enable restoration of historical data of a storage system. The method may comprise receiving at least one access request for a first set of historical data. The method may also comprise identifying a second set of historical data, wherein the first set of historical data is a subset of the second set of historical data. The method may further comprise identifying, in the storage management system, one or more storage locations containing backup data for the second set of historical data. The method may additionally comprise storing a mapping list of the one or more identified storage locations to facilitate subsequent access requests for any of the second set of historical data.
摘要翻译： 公开了一种用于在存储管理系统中重新映射数据的技术。 在一个特定示例性实施例中，该技术可以被实现为用于在具有能够恢复存储系统的历史数据的备份数据的存储管理系统中重新映射数据的方法。 该方法可以包括接收对第一组历史数据的至少一个访问请求。 该方法还可以包括识别第二组历史数据，其中第一组历史数据是第二组历史数据的子集。 该方法还可以包括在存储管理系统中识别包含第二组历史数据的备份数据的一个或多个存储位置。 该方法可以另外包括存储一个或多个所识别的存储位置的映射列表，以便于对第二组历史数据中的任何一个的后续访问请求。
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公开(公告)号：US07536583B2
公开(公告)日：2009-05-19
申请号：US11549386
申请日：2006-10-13
申请人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
发明人： Ronald Peter Passerini , Robert Warren Perry , Christopher Angelo Rocca , Michael Daniel Anthony
IPC分类号： G06F11/00
CPC分类号： G06F11/1435 , G06F11/1451 , G06F11/1458 , G06F11/1461 , G06F17/30943 , G06F2201/835 , G06F2201/84 , G11B27/105
摘要： A technique for timeline compression in a data store is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for timeline compression in a storage system, wherein digital content of the storage system is backed up to enable restoration of the digital content to one or more points in a timeline. The method may comprise selecting a time interval in the timeline. The method may also comprise identifying one or more sets of backup data recorded for the selected time interval, wherein the identified one or more sets of backup data represent at least a portion of old data overwritten during the selected time interval. The method may further comprise discarding other backup data recorded for the selected time interval, thereby reducing a granularity level of the timeline in the selected time interval.
摘要翻译： 公开了一种用于数据存储中的时间线压缩的技术。 在一个特定的示例性实施例中，该技术可以被实现为存储系统中的时间线压缩的方法，其中存储系统的数字内容被备份以使数字内容能够恢复到时间线中的一个或多个点。 该方法可以包括选择时间线中的时间间隔。 该方法还可以包括识别针对所选择的时间间隔记录的一组或多组备份数据，其中所识别的一组或多组备份数据表示在所选择的时间间隔期间重写的旧数据的至少一部分。 该方法还可以包括丢弃在所选择的时间间隔中记录的其他备份数据，从而减少所选择的时间间隔中时间线的粒度级别。
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公开(公告)号：US07049542B2
公开(公告)日：2006-05-23
申请号：US10948784
申请日：2004-09-24
IPC分类号： B23K26/00
CPC分类号： B23K26/26 , B23K26/0838 , B23K26/702 , B23K37/0408 , B23K2101/18 , B23K2101/185
摘要： Disclosed herein is a laser welding system having a travel path to carry a first blank and a second blank. An upstream clamp assembly and a downstream clamp assembly are positioned on the travel path and each of the upstream and downstream clamp assemblies are movable to an open position to allow the first blank to pass through the upstream clamp assembly to a first location within the downstream clamp assembly. A laser welding source is directed at a weld location on the travel path between the upstream and downstream clamp assemblies. At least one locating means is operable to locate the first weld edge adjacent the weld location. A first displacement means displaces the first weld edge against the locating means. The downstream clamp assembly is movable from the open position to a closed clamped position to clamp the first blank with the first weld edge adjacent the weld location. The locating means is operable to be withdrawn from the travel path. The upstream clamp assembly is movable from the open position to an intermediate position, which is selected to guide the second blank to pass through the upstream clamp assembly in a substantially coplanar relationship with the first blank so that the second weld edge makes contact with, but not past, the first weld edge. A second displacement means displaces the second blank to a location adjacent the weld location where the second weld edge abuts the first weld edge. The upstream clamp assembly is movable from the intermediate position to a closed clamped position to clamp the second blank and the the laser welding source is operable to fuse the first and second weld edges blanks together.
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公开(公告)号：US06803538B2
公开(公告)日：2004-10-12
申请号：US10229261
申请日：2002-08-28
IPC分类号： B23K2600
CPC分类号： B23K26/26 , B23K26/0838 , B23K26/702 , B23K37/0408 , B23K2101/18 , B23K2101/185
摘要： Disclosed herein is a laser welding system having a travel path to carry a first blank and a second blank. An upstream clamp assembly and a downstream clamp assembly are positioned on the travel path and each of the upstream and downstream clamp assemblies are movable to an open position to allow the first blank to pass through the upstream clamp assembly to a first location within the downstream clamp assembly. A laser welding source is directed at a weld location on the travel path between the upstream and downstream clamp assemblies. At least one locating means is operable to locate the first weld edge adjacent the weld location. A first displacement means displaces the first weld edge against the locating means. The downstream clamp assembly is movable from the open position to a closed clamped position to clamp the first blank with the first weld edge adjacent the weld location. The locating means is operable to be withdrawn from the travel path. The upstream clamp assembly is movable from the open position to an intermediate position, which is selected to guide the second blank to pass through the upstream clamp assembly in a substantially coplanar relationship with the first blank so that the second weld edge makes contact with, but not past, the first weld edge. A second displacement means displaces the second blank to a location adjacent the weld location where the second weld edge abuts the first weld edge. The upstream clamp assembly is movable from the intermediate position to a closed clamped position to clamp the second blank and the the laser welding source is operable to fuse the first and second weld edges blanks together.
摘要翻译： 本文公开了一种激光焊接系统，其具有用于承载第一坯件和第二坯件的行进路径。 上游夹具组件和下游夹具组件定位在行进路径上，并且上游和下游夹具组件中的每一个可移动到打开位置，以允许第一坯料通过上游夹具组件到达下游夹具内的第一位置 部件。 激光焊接源指向在上游和下游夹具组件之间的行进路径上的焊接位置。 至少一个定位装置可操作以将第一焊接边缘定位在焊接位置附近。 第一位移装置将第一焊接边缘抵靠定位装置移位。 下游夹具组件可从打开位置移动到闭合夹紧位置，以将第一坯料与邻近焊接位置的第一焊接边缘夹紧。 定位装置可操作以从行进路径中取出。 上游夹具组件可从打开位置移动到中间位置，中间位置被选择为引导第二坯料以与第一坯料基本上共面的关系通过上游夹具组件，使得第二焊接边缘与...接触，但是 没有过去，第一个焊缝。 第二位移装置将第二坯料移位到邻近第二焊接边缘邻接第一焊接边缘的焊接位置的位置。 上游夹具组件可从中间位置移动到闭合夹紧位置以夹紧第二坯料，并且激光焊接源可操作以将第一和第二焊接边缘毛坯熔合在一起。
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