公开(公告)号：US20060258189A1

公开(公告)日：2006-11-16

申请号：US11432212

申请日：2006-05-10

申请人： Wei Hua Pan

发明人： Wei Hua Pan

IPC分类号： H05K1/00

CPC分类号： H01R12/716 ,  H01R12/707 ,  H01R12/725

摘要： An electrical connector comprises an insulative housing, front and rear channels in the insulative housing and a hollow space defined between the front and corresponding rear channel, a plurality of front and rear contacts received respectively in said front and rear channels, said hollow space defines at least one block for separating the front and the rear contacts from each other, and avoid the front and rear contacts contacting each other for assuring the stable transmission of the signal.

摘要翻译： 电连接器包括绝缘壳体，绝缘壳体中的前通道和后通道以及限定在前后通道之间的中空空间，分别容纳在前通道和后通道中的多个前后触头，所述中空空间限定在 用于将前触点和后触头彼此分离的至少一个块，并且避免前触头和后触头彼此接触以确保信号的稳定传输。

公开(公告)号：US20050272308A1

公开(公告)日：2005-12-08

申请号：US11028030

申请日：2004-12-31

申请人： Wei-Hua Pan ,  Zhi-Qiang Li

发明人： Wei-Hua Pan ,  Zhi-Qiang Li

IPC分类号： H01R12/71 ,  H01R13/66 ,  H01R13/74

CPC分类号： H01R12/7064 ,  H01R12/7052

摘要： An electrical connector adapted for mounting on a Printed Circuit Board (PCB), comprises an insulative housing, a plurality of terminals loaded in the insulative housing and a board lock device assembled in the insulative housing. The insulative housing comprises a base portion having a PCB mounting face and a mating portion extending from the base portion. The base portion defines a boardlock-receiving cavity and is formed with a block adjacent to the cavity. The board lock device comprises a retaining plate retained in the cavity and substantially parallel to the PCB mounting face of the base portion and a lock plate perpendicularly extending from the retaining plate beyond the PCB mounting face of the base portion for locking with the PCB. The retaining plate is supported by the block for preventing the board lock device from moving along a direction perpendicular to the PCB mounting face of the base portion.

摘要翻译： 适于安装在印刷电路板（PCB）上的电连接器包括绝缘壳体，装在绝缘壳体中的多个端子和组装在绝缘壳体中的板锁装置。 绝缘壳体包括具有PCB安装面和从基部延伸的配合部分的基部。 基座部分限定了板锁接收腔，并且形成有与腔相邻的块。 板锁定装置包括保持在腔体中并基本上平行于基部的PCB安装面的保持板，以及从保持板垂直延伸超过基座部分的PCB安装面的锁定板，用于与PCB锁定。 保持板由块支撑，用于防止板锁定装置沿着垂直于基部的PCB安装面的方向移动。

公开(公告)号：US06910900B2

公开(公告)日：2005-06-28

申请号：US10930137

申请日：2004-08-30

申请人： Wei-Hua Pan

发明人： Wei-Hua Pan

IPC分类号： H01R12/16 ,  H01R13/658 ,  H01R13/648

CPC分类号： H01R13/6582

摘要： An electrical connector includes a dielectric housing defining a mating space with a pair of two opposite side wall by two sides thereof, a plurality of passageways formed in an inner face of each of the side walls, a number of signal and grounding terminals received in corresponding passageways, respectively, a shielding member attached to the side walls and a grounding member. Each grounding member includes an intermediate portion and three spaced beams extending from a side of the intermediate portion along a same direction. A middle one of the three beams is snugly retained in corresponding channel. The other two beams electrically and mechanically press the grounding terminal and the shield plate against the side wall, respectively.

摘要翻译： 电连接器包括绝缘壳体，该绝缘壳体通过两侧相对的一对相对的侧壁限定配合空间，多个通道形成在每个侧壁的内表面中，多个信号和接地端子被接收在相应的 通道分别连接到侧壁上的屏蔽构件和接地构件。 每个接地构件包括中间部分和沿着相同方向从中间部分的一侧延伸的三个间隔开的梁。 三个光束中的中间一个被紧贴地保留在相应的通道中。 另外两根光束分别电气地和机械地将接地端子和屏蔽板压靠在侧壁上。

公开(公告)号：US20050107326A1

公开(公告)日：2005-05-19

申请号：US10935962

申请日：2004-09-08

申请人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

发明人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P31/04 ,  C08K5/20 ,  C08K5/29 ,  C12N7/00 ,  C12N9/00 ,  C12N15/113 ,  C12N15/74 ,  A01K67/00 ,  C07H21/02

CPC分类号： C08K5/20 ,  A61K38/00 ,  A61K48/00 ,  C08K5/29 ,  C12N15/113 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/317 ,  C12N2799/021 ,  C08L69/00

摘要： The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

摘要翻译： 本发明涉及对病原体致死的毒性试剂的发现，鉴定和表征以及将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒物剂和用于将这些毒物剂靶向病变细胞以便治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明对消除耐药性病原体（如抗生素抗性细菌）和耐药性疾病细胞（如耐药性癌细胞）具有重要意义。

公开(公告)号：US20050048841A1

公开(公告)日：2005-03-03

申请号：US10927829

申请日：2004-08-27

申请人： Wei-Hua Pan

发明人： Wei-Hua Pan

IPC分类号： H01R12/16 ,  H01R13/658 ,  H01R13/648

CPC分类号： H01R13/6582

摘要： An electrical connector (1) includes a dielectric housing (10), a number of terminals (20) received in the dielectric housing and a pair of shielding plates attached to outer faces of the side walls. The dielectric housing includes a mating face, a pair of side walls extending from the mating face and a mating space in the mating face between the side walls. Each side wall includes a pair of protrusions and a recess in the outer face thereof. Each terminal includes a contact portion exposed to the mating space. Each shielding plate is formed with a retention blade engaging with the pair of protrusions and a spring tang received in the recess for preventing the shielding plate from moving away from the mating face.

摘要翻译： 电连接器（1）包括绝缘壳体（10），容纳在电介质壳体中的多个端子（20）和附接到侧壁外表面的一对屏蔽板。 绝缘壳体包括配合面，从配合面延伸的一对侧壁和侧壁之间的配合面中的配合空间。 每个侧壁在其外表面上包括一对突起和凹部。 每个端子包括暴露于配合空间的接触部分。 每个屏蔽板形成有与所述一对突起接合的保持刮片和容纳在凹部中的弹簧柄，用于防止屏蔽板远离配合面移动。

公开(公告)号：US07732197B2

公开(公告)日：2010-06-08

申请号：US10082973

申请日：2002-02-26

申请人： James S. Norris ,  Gary A. Clawson ,  Michael G. Schmidt ,  Brian Hoel ,  Wei-Hua Pan ,  Joseph W. Dolan

发明人： James S. Norris ,  Gary A. Clawson ,  Michael G. Schmidt ,  Brian Hoel ,  Wei-Hua Pan ,  Joseph W. Dolan

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12Q1/08 ,  C12N5/00 ,  C12N15/00

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/127 ,  C12N2799/021

摘要： The present invention relates to multi-ribozymes and their use to target RNA in a tissue-specific, target RNA-specific, or pathogen-specific manner for the treatment of cancers, proliferative disease, and bacterial, parasitic and viral infections. More specifically, the present invention relates to the use of virions and viral vectors to package and deliver DNA encoding the multi-ribozymes to a host. The present invention relates to the use of liposomes and lipid-DNA complexes to deliver DNA encoding ribozymes to a host. Most specifically, the invention relates to the use of target specific virions to package and deliver DNA comprising a target specific promoter and encoding a ribozyme(s) directed to the target organism nucleic acids. The present invention further relates to a novel vectors encoding a multi-ribozyme structure with enhanced 5′ and/or 3′ autocatalytically cleaving ribozymes. The invention further relates to nucleotides encoding a multi-ribozyme comprising one or more ribozyme cassettes which contain one or more trans-acting ribozymes and one or more autocatalytically cleaving ribozyme sequences.

摘要翻译： 本发明涉及多核酶及其用于以组织特异性，靶RNA特异性或病原体特异性方式靶向用于治疗癌症，增殖性疾病和细菌，寄生虫和病毒感染的RNA的用途。 更具体地，本发明涉及病毒粒子和病毒载体用于将编码多核酶的DNA包装并递送至宿主的用途。 本发明涉及脂质体和脂质DNA复合物将编码核酶的DNA递送至宿主的用途。 最具体地，本发明涉及靶特异性病毒体用于包装和递送包含靶特异性启动子并编码针对靶生物核酸的核酶的DNA的用途。 本发明还涉及编码具有增强的5'和/或3'自动催化裂解核酶的多核酶结构的新载体。 本发明还涉及编码多核酶的核苷酸，其包含一个或多个含有一个或多个反式作用核酶和一个或多个自动催化裂解核酶序列的核酶盒。

公开(公告)号：US20100036107A1

公开(公告)日：2010-02-11

申请号：US12578035

申请日：2009-10-13

申请人： Gary A. Clawson ,  Wei-Hua Pan ,  Ping Xin

发明人： Gary A. Clawson ,  Wei-Hua Pan ,  Ping Xin

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1131 ,  A61K31/19 ,  A61K31/60 ,  A61K45/06 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/317 ,  Y02A50/465 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

摘要翻译： 本发明提供了分离的核酸。 例如，本发明提供了分离的核酸，其具有至少一条具有彼此互补的有义和反义序列的链。 本发明还提供具有至少一条链的分离的核酸，其是互补互补的有义和反义序列的模板。 此外，本发明提供了含有本文提供的一种或多种分离的核酸的细胞，病毒和转基因动物（例如，转基因非人动物）以及使用本文提供的一种或多种分离的核酸的方法 降低细胞内的RNA水平（例如mRNA）。

公开(公告)号：US20090191763A1

公开(公告)日：2009-07-30

申请号：US12322230

申请日：2009-01-29

申请人： Jian-Kuang Zhu ,  Xiao-Gao Yang ,  Wei-Hua Pan

发明人： Jian-Kuang Zhu ,  Xiao-Gao Yang ,  Wei-Hua Pan

IPC分类号： H01R24/00

CPC分类号： H01R12/716 ,  H01R12/7082 ,  H01R12/725

摘要： An electrical connector includes a main board (5) with a first card edge connector (1) mounted thereon, a sub-board (6) with a second card edge connector (2) mounted thereon, and a pair of complementary board to board connectors (3, 4) mounted on the main board (5) and the sub-board (6) respectively. The first and second card edge connectors (1, 2) are aligned with each other in a vertical direction and the second card edge connector (2) is on top of the first card edge connector (1).

公开(公告)号：US20060269530A1

公开(公告)日：2006-11-30

申请号：US10552914

申请日：2004-02-23

申请人： Gary Clawson ,  Wei-Hua Pan ,  Ping Xin

发明人： Gary Clawson ,  Wei-Hua Pan ,  Ping Xin

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N5/08 ,  C12N15/86 ,  C12N7/00

CPC分类号： C12N15/1131 ,  A61K31/19 ,  A61K31/60 ,  A61K45/06 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/317 ,  Y02A50/465 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

摘要翻译： 本发明提供分离的核酸。 例如，本发明提供了分离的核酸，其具有至少一条具有彼此互补的有义和反义序列的链。 本发明还提供具有至少一条链的分离的核酸，其是互补互补的有义和反义序列的模板。 此外，本发明提供了含有本文提供的一种或多种分离的核酸的细胞，病毒和转基因动物（例如，转基因非人动物）以及使用本文提供的一种或多种分离的核酸的方法 降低细胞内的RNA水平（例如mRNA）。

公开(公告)号：US07081014B2

公开(公告)日：2006-07-25

申请号：US11028030

申请日：2004-12-31

申请人： Wei-Hua Pan ,  Zhi-Qiang Li

发明人： Wei-Hua Pan ,  Zhi-Qiang Li

IPC分类号： H01R13/60

CPC分类号： H01R12/7064 ,  H01R12/7052

摘要： An electrical connector adapted for mounting on a Printed Circuit Board (PCB), comprises an insulative housing, a plurality of terminals loaded in the insulative housing and a board lock device assembled in the insulative housing. The insulative housing comprises a base portion having a PCB mounting face and a mating portion extending from the base portion. The base portion defines a boardlock-receiving cavity and is formed with a block adjacent to the cavity. The board lock device comprises a retaining plate retained in the cavity and substantially parallel to the PCB mounting face of the base portion and a lock plate perpendicularly extending from the retaining plate beyond the PCB mounting face of the base portion for locking with the PCB. The retaining plate is supported by the block for preventing the board lock device from moving along a direction perpendicular to the PCB mounting face of the base portion.

摘要翻译： 适于安装在印刷电路板（PCB）上的电连接器包括绝缘壳体，装在绝缘壳体中的多个端子和组装在绝缘壳体中的板锁装置。 绝缘壳体包括具有PCB安装面和从基部延伸的配合部分的基部。 基座部分限定了板锁接收腔，并且形成有与腔相邻的块。 板锁定装置包括保持在腔体中并基本上平行于基部的PCB安装面的保持板，以及从保持板垂直延伸超过基座部分的PCB安装面的锁定板，用于与PCB锁定。 保持板由块支撑，用于防止板锁定装置沿着垂直于基部的PCB安装面的方向移动。