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    Tissue-specific and pathogen-specific toxic agents and ribozymes
    1.
    发明申请
    Tissue-specific and pathogen-specific toxic agents and ribozymes 失效
    组织特异性和病原体特异性毒素和核酶

    公开(公告)号：US20050107326A1

    公开(公告)日：2005-05-19

    申请号：US10935962

    申请日：2004-09-08

    申请人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    发明人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    IPC分类号： C12N15/09 ,  A61K35/74 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P31/04 ,  C08K5/20 ,  C08K5/29 ,  C12N7/00 ,  C12N9/00 ,  C12N15/113 ,  C12N15/74 ,  A01K67/00 ,  C07H21/02

    CPC分类号： C08K5/20 ,  A61K38/00 ,  A61K48/00 ,  C08K5/29 ,  C12N15/113 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/317 ,  C12N2799/021 ,  C08L69/00

    摘要： The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

    摘要翻译： 本发明涉及对病原体致死的毒性试剂的发现，鉴定和表征以及将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒物剂和用于将这些毒物剂靶向病变细胞以便治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明对消除耐药性病原体（如抗生素抗性细菌）和耐药性疾病细胞（如耐药性癌细胞）具有重要意义。

    Tissue-specific and pathogen-specific toxic agents, ribozymes, dnazymes and antisense oligonucleotides, and methods of use thereof
    2.
    发明申请
    Tissue-specific and pathogen-specific toxic agents, ribozymes, dnazymes and antisense oligonucleotides, and methods of use thereof 审中-公开
    组织特异性和病原体特异性毒性剂，核酶，dnazymes和反义寡核苷酸及其使用方法

    公开(公告)号：US20060223774A1

    公开(公告)日：2006-10-05

    申请号：US11375690

    申请日：2006-03-13

    申请人： James Norris ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Gary Clawson ,  Wei-Hua Pan

    发明人： James Norris ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Gary Clawson ,  Wei-Hua Pan

    IPC分类号： A61K48/00 ,  C07H21/02

    CPC分类号： C12N15/1131 ,  A61K38/00 ,  C12N15/113 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/317 ,  C12Q1/6811 ,  C12Q2521/337

    摘要： The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

    摘要翻译： 本发明涉及对病原体致死的毒性试剂的发现，鉴定和表征以及将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒物剂和用于将这些毒物剂靶向病变细胞以便治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明对消除耐药性病原体（如抗生素抗性细菌）和耐药性疾病细胞（如耐药性癌细胞）具有重要意义。

    Tissue-specific and pathogen-specific toxic agents and ribozymes
    3.
    发明授权
    Tissue-specific and pathogen-specific toxic agents and ribozymes 失效
    组织特异性和病原体特异性毒素和核酶

    公开(公告)号：US06271359B1

    公开(公告)日：2001-08-07

    申请号：US09291902

    申请日：1999-04-14

    申请人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    发明人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    IPC分类号： C07H2102

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2799/021

    摘要： The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention also has important implications in the eradication of drug-resistant pathogens and drug-resistant diseased cells (such as cancer cells).

    摘要翻译： 本发明涉及对病原体致死的毒性试剂的发现，鉴定和表征以及将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒物剂和用于将这些毒物剂靶向病变细胞以便治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明也对消除耐药病原体和耐药性疾病细胞（如癌细胞）具有重要意义。

    Tissue-specific and pathogen-specific ribozymes
    4.
    发明授权
    Tissue-specific and pathogen-specific ribozymes 失效
    组织特异性和病原体特异性毒素和核酶

    公开(公告)号：US07575918B2

    公开(公告)日：2009-08-18

    申请号：US10935962

    申请日：2004-09-08

    申请人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael G. Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    发明人： James Norris ,  Gary Clawson ,  Caroline Westwater ,  David Schofield ,  Michael G. Schmidt ,  Brian Hoel ,  Joseph Dolan ,  Wei-Hua Pan

    IPC分类号： C07H21/04 ,  C07H21/02 ,  C12Q1/68 ,  A61K31/70

    CPC分类号： C08K5/20 ,  A61K38/00 ,  A61K48/00 ,  C08K5/29 ,  C12N15/113 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/317 ,  C12N2799/021 ,  C08L69/00

    摘要： The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

    摘要翻译： 本发明涉及对病原体致死的毒性试剂的发现，鉴定和表征以及将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒物剂和用于将这些毒物剂靶向病变细胞以便治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明对消除耐药性病原体（如抗生素抗性细菌）和耐药性疾病细胞（如耐药性癌细胞）具有重要意义。

    Method and system for automating node configuration to facilitate peer-to-peer communication
    9.
    发明授权
    Method and system for automating node configuration to facilitate peer-to-peer communication 有权
    用于自动化节点配置以促进对等通信的方法和系统

    公开(公告)号：US07990896B1

    公开(公告)日：2011-08-02

    申请号：US11777653

    申请日：2007-07-13

    申请人： Jason Delker ,  John M. Everson ,  James Norris ,  Bryce A. Jones

    发明人： Jason Delker ,  John M. Everson ,  James Norris ,  Bryce A. Jones

    IPC分类号： H04L12/28

    CPC分类号： H04L29/12207 ,  H04L41/0843 ,  H04L41/0886 ,  H04L41/22 ,  H04L41/5012 ,  H04L61/20 ,  H04L67/34 ,  H04W8/245 ,  H04W76/14 ,  H04W92/18

    摘要： A method and system for configuring one or more prospective-participant nodes as participant nodes so as to enable the prospective-participant nodes to engage in a peer-to-peer communication is provided. In one exemplary embodiment, the method and system may be embodied as a common application that includes logic, in hardware or software form, for carrying out one or more of the functions for configuring one or more prospective-participant nodes as a participant node in a peer-to-peer network.In carrying out these functions, one of the participant nodes discovers its network-connection settings, and based on these settings, generates participant-node-configuration data that includes one or more network connection settings that define how to address the prospective-participant node as a participant node.When desiring to join the peer-to-peer network, the prospective-participant node and the participant node may establish a point-to-point communication link by engaging in a discovery process using so as to establish a data-link layer connection. After completing negotiation of the data-link-layer connection, the prospective-participant node and the participant node may communicate over the data-link-layer connection.The prospective-participant node may send to the participant node a request for network access. Responsively, the participant node sends to the prospective-participant node the participant-node-configuration data over the point-to-point connection. And the prospective-participant node configures itself using the participant-node-configuration data so as to become a participant node.

    摘要翻译： 提供了一种用于将一个或多个预期参与者节点配置为参与者节点以便使预期参与者节点参与对等通信的方法和系统。 在一个示例性实施例中，该方法和系统可以体现为一般的应用，其包括以硬件或软件形式的逻辑，用于执行用于将一个或多个预期参与者节点配置为参与者节点的一个或多个功能 对等网络。 在执行这些功能时，参与者节点之一发现其网络连接设置，并且基于这些设置，生成参与者节点配置数据，其包括一个或多个网络连接设置，其定义如何将预期参与者节点如 参与者节点。 当希望加入对等网络时，预期参与者节点和参与者节点可以通过参与使用以建立数据链路层连接的发现过程来建立点对点通信链路。 在完成数据链路层连接的协商之后，预期参与者节点和参与者节点可以通过数据链路层连接进行通信。 预期参与者节点可以向参与者节点发送网络访问请求。 响应地，参与者节点通过点到点连接向参与者节点配置数据发送参与者节点配置数据。 并且预期参与者节点使用参与者 - 节点配置数据来配置自身，以便成为参与者节点。

    Interpreting local search queries
    10.
    发明授权
    Interpreting local search queries 有权
    解读本地搜索查询

    公开(公告)号：US07917490B2

    公开(公告)日：2011-03-29

    申请号：US11775066

    申请日：2007-07-09

    申请人： James Norris ,  Gregory John Donaker ,  Nina Weiyu Kang

    发明人： James Norris ,  Gregory John Donaker ,  Nina Weiyu Kang

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3087 ,  G06Q30/0261

    摘要： A search query may be interpreted as a number of possible interpretations, and each interpretation may be explored before the results of the search are sent to a user. In one embodiment, a device may split the search query into partitions. Each of the partitions may be submitted, as a search query, to search repositories. Confidence scores based on the results returned from the repositories may be used to determine a measure of confidence of the repository in the search query interpretation.

    摘要翻译： 搜索查询可以被解释为许多可能的解释，并且可以在将搜索结果发送给用户之前探查每个解释。 在一个实施例中，设备可以将搜索查询拆分成分区。 可以将每个分区作为搜索查询提交到搜索库。 基于从存储库返回的结果的置信度分数可用于确定存储库在搜索查询解释中的置信度度。