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1.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并-1,4-二氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US09096546B2
公开(公告)日：2015-08-04
申请号：US12598882
申请日：2008-05-08
申请人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
发明人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
IPC分类号： A61K31/5513 , C07D243/14 , C07D401/02 , C07D403/02 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
CPC分类号： C07D243/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1-R8 are as defined herein.
摘要翻译： 本发明的芳基 - 和杂芳基取代的四氢苯并-1,4-二氮杂衍生物化合物由具有以下结构的式1（A-D）表示：其中取代基X和R 1 -R 8如本文所定义。
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2.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08791101B2
公开(公告)日：2014-07-29
申请号：US12917066
申请日：2010-11-01
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61K31/55 , C07D401/04
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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3.发明申请ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权ARYL-和HETEROARYL取代的四氢苯并噻吩并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20110046114A1
公开(公告)日：2011-02-24
申请号：US12917066
申请日：2010-11-01
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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4.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US07956050B2
公开(公告)日：2011-06-07
申请号：US11487884
申请日：2006-07-17
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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5.发明申请ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权芳基取代四氢呋喃-1,4-二氮杂萘并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20100137287A1
公开(公告)日：2010-06-03
申请号：US12598882
申请日：2008-05-08
申请人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson
发明人： Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson
IPC分类号： A61K31/5513 , C07D243/14 , A61P25/00
CPC分类号： C07D243/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1-R8 are as defined herein.
摘要翻译： 本发明的芳基 - 和杂芳基取代的四氢苯并-1,4-二氮杂衍生物化合物由具有以下结构的式1（A-D）表示：其中取代基X和R 1 -R 8如本文所定义。
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6.发明授权2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权2,5-亚甲基和2,5-乙基 - 四氢苯并氮杂衍生物及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US09045468B2
公开(公告)日：2015-06-02
申请号：US13211678
申请日：2011-08-17
申请人： Peter R. Guzzo , Shuang Liu , Kristen N. Ryan , Bruce F. Molino , Russell DeOrazio , Richard E. Olson , John E. Macor
发明人： Peter R. Guzzo , Shuang Liu , Kristen N. Ryan , Bruce F. Molino , Russell DeOrazio , Richard E. Olson , John E. Macor
IPC分类号： A61K31/55 , C07D453/00 , C07D519/00
CPC分类号： C07D453/00 , C07D519/00
摘要： The compounds of the present invention are represented by the following 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives having formula (I): where the carbon atom designated * is in the R or S configuration when n is 1 and the substituents X and R1-R7 are as defined herein.
摘要翻译： 本发明的化合物由以下具有式（I）的2,5-亚甲基 - 和2,5-亚乙基 - 四氢苯并吖庚因衍生物表示：当n为1时，其中指定为*为R或S构型的碳原子， 取代基X和R 1 -R 7如本文所定义。
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7.发明授权Aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳氧基和杂芳氧基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08987252B2
公开(公告)日：2015-03-24
申请号：US12598912
申请日：2008-05-08
IPC分类号： A61K31/55 , C07D223/16 , C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04
CPC分类号： C07D471/04 , C07D223/16 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S configuration and the substituents X and R1—R9 are as defined herein.
摘要翻译： 本发明的芳氧基 - 和杂芳氧基取代的四氢苯并吖庚因衍生物化合物由具有以下结构的式（I）（AE）表示，其中指定为*的碳原子为R或S构型，取代基X和R 1 -R 9为 如本文所定义。
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8.发明申请ARYLOXY- AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权ARYLOXY-和HETEROARYLOXY取代的四氢苯并嗪和其用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20100210624A1
公开(公告)日：2010-08-19
申请号：US12598912
申请日：2008-05-08
IPC分类号： A61K31/55 , C07D223/16 , A61P21/00 , A61P25/16 , A61P25/28 , A61P3/04 , A61P3/10 , A61P15/00
CPC分类号： C07D471/04 , C07D223/16 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S configuration and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的芳氧基 - 和杂芳氧基取代的四氢苯并吖庚因衍生物化合物由具有以下结构的式（I）（AE）表示，其中指定为*的碳原子为R或S构型，取代基X和R 1 -R 9为 如本文所定义。
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9.发明申请Aza-Bicyclic Amine N-Oxide Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligand Pro-Drugs 有权氮杂双环胺氧化物作为α-7烟碱乙酰胆碱受体配体药物公开(公告)号：US20120108596A1
公开(公告)日：2012-05-03
申请号：US13097153
申请日：2011-04-29
申请人： Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
发明人： Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
IPC分类号： A61K31/4725 , A61P25/18 , A61P25/28 , A61K31/439 , A61K31/498 , A61K31/506 , A61K31/444 , A61K31/497 , C07D498/20 , C07D519/00
CPC分类号： C07D498/10
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是用于烟碱型α7受体的配体，激动剂和部分激动剂的前药，并且可用于治疗中枢神经系统的各种疾病，特别是情感和神经变性疾病。
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10.发明申请公开(公告)号：US20100099684A1
公开(公告)日：2010-04-22
申请号：US12607354
申请日：2009-10-28
申请人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A61K31/499 , C07D239/12 , C07D241/36 , C07D401/14 , A61K31/498 , A61K31/444 , A61P25/28
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
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