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公开(公告)号:US07584087B2
公开(公告)日:2009-09-01
申请号:US11099958
申请日:2005-04-06
申请人: Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
发明人: Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
CPC分类号: C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要: A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译: 人蛋白激酶Cθ(PKCθ)的三维结构可用于设计与PKCθ相互作用的试剂的方法中。 该药物可以是PKCθ活性的抑制剂。
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公开(公告)号:US20060003431A1
公开(公告)日:2006-01-05
申请号:US11099958
申请日:2005-04-06
申请人: Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
发明人: Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
IPC分类号: G06F19/00 , G01N33/48 , G01N33/50 , C12N9/12 , A61K31/553
CPC分类号: C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要: A three-dimensional structure of protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译: 蛋白激酶Cθ(PKCθ)的三维结构可用于设计与PKCθ相互作用的试剂的方法。 该药物可以是PKCθ活性的抑制剂。
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公开(公告)号:US20050164323A1
公开(公告)日:2005-07-28
申请号:US11022327
申请日:2004-12-22
CPC分类号: C12Q1/485 , G01N33/5047 , G01N2500/00 , G01N2800/122
摘要: Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC-θ protein, as well as for agents that inhibit the kinase activity of a PKC-θ protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. The methods also include screening for agents that inhibit the production of a reporter gene product encoded by a nucleic acid sequence operably linked to a PKC-θ promoter. Also disclosed are methods of treating asthma that include administering an agent that inhibits the production of a functional PKC-θ protein or the kinase activity of a PKC-θ protein or a functional fragment thereof. An isolated mast cell lacking expression of endogenous PKC-θ is also disclosed.
摘要翻译: 公开了可用于治疗哮喘的药剂的方法。 所述方法包括筛选抑制PKC-θ蛋白的产生的试剂,以及抑制PKC-θ蛋白或其功能片段的激酶活性的试剂,其中所述试剂可用于治疗哮喘。 所述方法还包括筛选抑制由与PKC-θ启动子可操作地连接的核酸序列编码的报告基因产物的产物。 还公开了治疗哮喘的方法,其包括施用抑制功能性PKC-θ蛋白产生的药物或PKC-θ蛋白或其功能片段的激酶活性。 还公开了缺乏内源性PKC-θ表达的分离的肥大细胞。
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公开(公告)号:US20110033884A1
公开(公告)日:2011-02-10
申请号:US12761704
申请日:2010-04-16
申请人: Clive Wood , Gordon J. Freeman , Divya Chaudhary
发明人: Clive Wood , Gordon J. Freeman , Divya Chaudhary
IPC分类号: C12Q1/02
CPC分类号: G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2333/70532 , G01N2333/912
摘要: Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an activating antibody that recognizes PD-1, a form of B7-4 that binds to an inhibitory receptor, and a small molecule that binds to PD-1. Agents which are useful for inhibiting signaling via PD-1 to upregulate an immune response include a blocking antibody that recognizes PD-1, a non-activating form of B7-4, an antibody that recognizes B7-4, and a soluble form of PD-1. Also disclosed is a method for modulating the interaction of B7-4 with an inhibitory receptor on an immune cell. The method comprises contacting an antigen presenting cell which expresses B7-4 with an agent such as a form of B7-4, a form of PD-1, or an agent that modulates the interaction of B7-4 and PD-1. Also disclosed is a method for inhibiting activation of an immune cell via a non-apoptotic mechanism by increasing the activity or expression of PD-1 in the immune cell. The disclosed methods for modulating an immune response are useful, for instance as therapeutic treatment of a subject with conditions that would benefit from immune response modulation. For instance, a condition such as a tumor, a neurological disease, or an immunosuppressive disease, would be treated by upregulating an immune response, and conditions such as a transplant, an allergy, or an autoimmune disorder would benefit from downregulation of an immune response. Assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule are also disclosed. Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.
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公开(公告)号:US20080274490A1
公开(公告)日:2008-11-06
申请号:US11519186
申请日:2006-09-11
IPC分类号: C12Q1/02
CPC分类号: G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2333/70532 , G01N2333/912
摘要: Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an activating antibody that recognizes PD-1, a form of B7-4 that binds to an inhibitory receptor, and a small molecule that binds to PD-1. Agents which are useful for inhibiting signaling via PD-1 to upregulate an immune response include a blocking antibody that recognizes PD-1, a non-activating form of B7-4, an antibody that recognizes B7-4, and a soluble form of PD-1. Also disclosed is a method for modulating the interaction of B7-4 with an inhibitory receptor on an immune cell. The method comprises contacting an antigen presenting cell which expresses B7-4 with an agent such as a form of B7-4, a form of PD-1, or an agent that modulates the interaction of B7-4 and PD-1. Also disclosed is a method for inhibiting activation of an immune cell via a non-apoptotic mechanism by increasing the activity or expression of PD-1 in the immune cell. The disclosed methods for modulating an immune response are useful, for instance as therapeutic treatment of a subject with conditions that would benefit from immune response modulation. For instance, a condition such as a tumor, a neurological disease, or an immunosuppressive disease, would be treated by upregulating an immune response, and conditions such as a transplant, an allergy, or an autoimmune disorder would benefit from downregulation of an immune response. Assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule are also disclosed. Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.
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6.
公开(公告)号:US07105328B2
公开(公告)日:2006-09-12
申请号:US10115615
申请日:2002-04-02
申请人: Clive Wood , Gordon J. Freeman , Divya Chaudhary
发明人: Clive Wood , Gordon J. Freeman , Divya Chaudhary
IPC分类号: C12N9/12 , G01N33/567
CPC分类号: G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2333/70532 , G01N2333/912
摘要: Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1.
摘要翻译: 公开了用于鉴定调节B7-4或PD-1的活性或通过信号传导通过B7-4或PD-1,特别是调节B7-4或PD-1与靶分子的结合的化合物的筛选测定。进一步披露的是疫苗和 含有通过PD-1调节信号传导的试剂的其他组合物。
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7.
公开(公告)号:US07700301B2
公开(公告)日:2010-04-20
申请号:US11519186
申请日:2006-09-11
IPC分类号: G01N33/53
CPC分类号: G01N33/505 , G01N33/5052 , G01N33/6863 , G01N2333/70532 , G01N2333/912
摘要: Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule.
摘要翻译: 公开了用于鉴定调节B7-4或PD-1的活性或通过信号通路的化合物的筛选测定,特别是其调节B7-4或PD-1与靶分子的结合。
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8.
公开(公告)号:US20090325176A1
公开(公告)日:2009-12-31
申请号:US12478940
申请日:2009-06-05
申请人: Margot Mary O'Toole , Frederick William Immermann , Padmalatha Sunkara Reddy , Andrew Arthur Hill , John Louis Ryan , Andrew Joseph Dorner , Cristina Ileana Csimma , Charlotte Marie McKee , Wei Liu , Divya Chaudhary , Matthew Ren Silver
发明人: Margot Mary O'Toole , Frederick William Immermann , Padmalatha Sunkara Reddy , Andrew Arthur Hill , John Louis Ryan , Andrew Joseph Dorner , Cristina Ileana Csimma , Charlotte Marie McKee , Wei Liu , Divya Chaudhary , Matthew Ren Silver
CPC分类号: G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5047 , G01N33/6845 , G01N2800/122 , G01N2800/52 , G01N2800/60
摘要: The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma.
摘要翻译: 本发明通过评估来自患者的样品中哮喘恶化基因产物的表达水平,提供了用于评估,诊断或预测哮喘恶化的方法。 本发明的标记物可用于鉴定或评估能够调节患有哮喘的受试者的标志物表达水平的试剂的方法。
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