公开(公告)号：US09265870B2

公开(公告)日：2016-02-23

申请号：US13273185

申请日：2011-10-13

申请人： Steven H. Reichenbach ,  Pieter W. C. J. le Blanc ,  Yi-Ren Woo ,  David Gary Eldridge ,  Stephen G. Briana ,  William V. Hodges ,  Eric Lee

发明人： Steven H. Reichenbach ,  Pieter W. C. J. le Blanc ,  Yi-Ren Woo ,  David Gary Eldridge ,  Stephen G. Briana ,  William V. Hodges ,  Eric Lee

IPC分类号： A61M1/10 ,  A61M1/12

CPC分类号： A61M1/1008 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1031 ,  A61M1/12 ,  A61M1/122 ,  A61M1/125 ,  A61M1/127 ,  A61M25/005 ,  A61M2205/04

摘要： A blood pump includes a rotor having a flared portion downstream proximate a downstream bearing that supports the rotor. The flared portion of the rotor includes a width greater than a width of an upstream portion of the rotor. A blood pump also includes a housing having an internal wall with a flared portion downstream of a motor stator and proximate a transverse outlet.

摘要翻译： 血泵包括具有支撑转子的下游轴承附近的扩张部分的转子。 转子的扩口部分的宽度大于转子上游部分的宽度。 血液泵还包括具有内壁的外壳，其具有位于马达定子下游并且靠近横向出口的扩口部分。

公开(公告)号：US20120046515A1

公开(公告)日：2012-02-23

申请号：US13213571

申请日：2011-08-19

申请人： Yi-Ren Woo ,  Steven H. Reichenbach ,  Stephen Briana ,  Kelly Walsh ,  Kevin Bourque

发明人： Yi-Ren Woo ,  Steven H. Reichenbach ,  Stephen Briana ,  Kelly Walsh ,  Kevin Bourque

IPC分类号： A61M1/12

CPC分类号： A61M39/0247 ,  A61M39/0208 ,  A61M2039/0223 ,  A61M2039/0261

摘要： A percutaneous cable is attached to a mechanical cardiac pump and is passed through the skin. Sutures can be used to stabilize the cable against movement to prevent disturbing tissue surrounding cable and thereby reduce the incidence of infection. A funnel-shaped tubular device can be used where the cable exits the skin to allow the cable to flex below or near the skin surface as may be desired to accommodate physical activity of a patient. An anchor can be attached to the cable and implanted below the skin surface to stabilize the cable against movement. The anchor can include any one or a combination of a flat mesh material, a bundle of ultrafine filaments, and a barbed filament.

摘要翻译： 经皮电缆连接到机械式心脏泵并通过皮肤。 可以使用缝合线来稳定电缆以防止运动，以防止扰乱组织周围的电缆，从而减少感染的发生。 可以使用漏斗形管状装置，其中电缆离开皮肤，以允许电缆弯曲到皮肤表面下方或附近，如可能需要的，以适应患者的身体活动。 锚固件可以附接到电缆并且植入皮肤表面以稳定电缆以防止运动。 锚固体可以包括扁平网状材料，超细丝束和带刺的细丝中的任何一种或组合。

公开(公告)号：US20100249922A1

公开(公告)日：2010-09-30

申请号：US12733762

申请日：2008-09-19

申请人： XueMei Li ,  Yi-Ren Woo

发明人： XueMei Li ,  Yi-Ren Woo

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2250/0018

摘要： A structure for use as a prosthetic heart valve leaflet includes a two-dimensional array that is made up of one or more fiber strands and that is covered by a web of polymer material to produce a sheet that is impervious to blood. This sheet is stretchable along two axes that lie in the plane of the sheet and that are at an angle to one another. The sheet may be more easily stretched along one of these axes than along the other axis. Along each axis the amount of force required to produce initial increments of stretch may be less than the amount of force required to produce subsequent increments of stretch (i.e., increments of stretch beyond the initial increments).

摘要翻译： 用作假体心脏瓣膜小叶的结构包括由一根或多根纤维束组成并由聚合物材料的网覆盖以产生不透血液的片的二维阵列。 该片材沿着位于片材平面中并且彼此成角度的两个轴线是可拉伸的。 该片材可以沿着这些轴线沿着另一个轴线更容易地拉伸。 沿着每个轴，产生初始拉伸增量所需的力的量可以小于产生随后的拉伸增量所需的力的量（即，超出初始增量的拉伸增量）。

公开(公告)号：US20090131927A1

公开(公告)日：2009-05-21

申请号：US12272185

申请日：2008-11-17

申请人： Nathan Kastelein ,  Ashwini K. Pandey ,  Yi-Ren Woo ,  Raju R. Viswanathan ,  Gareth T. Munger ,  Christopher D. Minar ,  Roger G. Riedel, JR.

发明人： Nathan Kastelein ,  Ashwini K. Pandey ,  Yi-Ren Woo ,  Raju R. Viswanathan ,  Gareth T. Munger ,  Christopher D. Minar ,  Roger G. Riedel, JR.

IPC分类号： A61B18/18 ,  A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00083 ,  A61B2018/00702 ,  A61B2018/00779 ,  A61B2018/144 ,  A61B2218/002

摘要： Devices for the generation and detection of an ablative plasma discharge in a subject are presented. Methods of use, including navigation and operation of the devices to facilitate minimally invasive therapeutic procedures are disclosed.

摘要翻译： 提出了用于产生和检测受试者中烧蚀等离子体放电的装置。 公开了使用方法，包括用于促进微创治疗程序的装置的导航和操作。

公开(公告)号：US06953332B1

公开(公告)日：2005-10-11

申请号：US09724007

申请日：2000-11-28

申请人： James L. Kurk ,  Chad Q. Cai ,  Steven D. Kruse ,  Yi-Ren Woo

发明人： James L. Kurk ,  Chad Q. Cai ,  Steven D. Kruse ,  Yi-Ren Woo

IPC分类号： A61F2/24 ,  A61F2/82 ,  B29C33/42 ,  B29C41/14

CPC分类号： B29C41/14 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0029 ,  B29C33/42 ,  B29L2031/7534 ,  Y10S264/60

摘要： Improved dip coating methods and mandrels for forming polymer leaflets and valve prostheses generally involve one or more features on the mandrel that facilitate the processing. The mandrel has a top surface and an outer surface comprising a plurality of ridges and contoured surfaces extending to the ridges. An edge on the mandrel separates the top surface and the contoured surfaces, with the mandrel edge corresponding to the free edge of the leaflet. In preferred embodiments, the edge separating the top surface from the contoured surfaces is sharp. The polymer formed on the top surface can be efficiently separated from the remaining portions of the polymer structure to form the free edges of the leaflets.

摘要翻译： 用于形成聚合物小叶和瓣膜假体的改进的浸涂方法和心轴通常涉及在心轴上的一个或多个特征，其有利于加工。 心轴具有顶表面和外表面，该外表面包括延伸到脊的多个脊和轮廓表面。 心轴上的边缘分离顶表面和轮廓表面，心轴边缘对应于传单的自由边缘。 在优选实施例中，将顶表面与轮廓表面分开的边缘是锋利的。 形成在顶表面上的聚合物可以有效地从聚合物结构的其余部分分离以形成传单的自由边缘。

公开(公告)号：US5702400A

公开(公告)日：1997-12-30

申请号：US766539

申请日：1996-12-11

申请人： Kyle Brown ,  Stephen J. Van Noy ,  Yi-Ren Woo ,  Lars D. Jensen

发明人： Kyle Brown ,  Stephen J. Van Noy ,  Yi-Ren Woo ,  Lars D. Jensen

IPC分类号： A61F2/16 ,  A61F9/00

CPC分类号： A61F2/1664 ,  Y10S623/907

摘要： A single piece intraocular lens folder that has a generally planar, open frame in the shape of a rounded "A" with a rimmed, open head at the top of the "A". The base of the "A" forms a pairs of opposing legs or handles that join to form a hinge at the intersection where the handles attach to the head. The hinge allows the handle to be squeezed together and spring apart when released. Squeezing the handles together causes the sides of the head to spread apart, thereby stretching the top edge of the head rim and pulling the top edge downward toward the hinge. The open head contains a pair of support jaws and a pair of serpentine folding jaws. The location of the serpentine jaws is such that when the top edge of the head rim moves toward the hinge, the serpentine jaws are squeezed together, causing the IOL to be folded in half. The serpentine shape of the folding jaws allow the haptics to pivot downward, thereby permitting the IOL to be folded along a plurality of axes.

摘要翻译： 单片式眼内透镜夹具，其具有大致平坦的开放框架，其形状为圆形“A”，在“A”的顶部具有边缘的开放头部。 “A”的底部形成一对相对的腿部或手柄，这些腿或手柄在手柄附接到头部的交叉处形成铰链。 铰链允许将手柄挤压在一起，释放时弹开。 将手柄压在一起使头部的两侧分开，从而拉伸头部边缘的顶部边缘并将顶部边缘向下拉向铰链。 敞开的头部包含一对支撑爪和一对蛇形折叠夹。 蛇形爪的位置使得当头部边缘的顶部边缘朝向铰链移动时，蛇形钳口被挤压在一起，使IOL折叠成一半。 折叠爪的蛇形形状允许触觉件向下枢转，从而允许IOL沿着多个轴线折叠。

公开(公告)号：US08409274B2

公开(公告)日：2013-04-02

申请号：US11796471

申请日：2007-04-26

申请人： XueMei Li ,  Yi-Ren Woo

发明人： XueMei Li ,  Yi-Ren Woo

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409

摘要： A prosthetic heart valve has an annular valve-perimeter-shape-defining structure having a radially outer surface. A clip structure is provided on the outer surface. This clip structure is used to attach flexible valve leaflets to the shape-defining structure. One or more retainer members may be used to help hold the leaflets in the clip structure.

摘要翻译： 假体心脏瓣膜具有具有径向外表面的环形阀周边形状限定结构。 夹子结构设置在外表面上。 该夹子结构用于将柔性瓣叶附接到形状限定结构。 可以使用一个或多个保持器构件来帮助将传单保持在夹子结构中。

公开(公告)号：US07578842B2

公开(公告)日：2009-08-25

申请号：US11542903

申请日：2006-10-03

申请人： Yi-Ren Woo

发明人： Yi-Ren Woo

IPC分类号： A61F2/24

CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/42

摘要： A prosthetic heart valve includes a hydrogel material in its sewing cuff. The hydrogel material may be accompanied by an anticoagulant. If the hydrogel (and/or any included anticoagulant) might react with a packaging solution in which the valve is stored after inclusion of the hydrogel (and any anticoagulant), the hydrogel (and any anticoagulant) may be included in a protective but deliberately frangible pouch in the sewing cuff. After the valve is out of the packaging solution, the pouch can be broken to render the hydrogel (and any coagulant) effective following implantation of the valve in a patient.

摘要翻译： 假体心脏瓣膜包括其缝合袖口中的水凝胶材料。 水凝胶材料可以伴随有抗凝剂。 如果水凝胶（和/或任何包含的抗凝血剂）可能在包含水凝胶（和任何抗凝血剂）之后与其中储存阀的包装溶液发生反应，则可将水凝胶（和任何抗凝血剂）包含在保护性但故意易碎的 袋缝在袖口。 在阀门脱离包装溶液之后，袋子可以被破坏，使得在将患者植入瓣膜之后使水凝胶（和任何凝结剂）有效。

公开(公告)号：US20080228264A1

公开(公告)日：2008-09-18

申请号：US11717305

申请日：2007-03-12

申请人： XueMei Li ,  Yi-Ren Woo

发明人： XueMei Li ,  Yi-Ren Woo

IPC分类号： A61F2/24 ,  A61B17/08 ,  A61F2/06

CPC分类号： A61F2/2415

摘要： A prosthetic heart valve of the type that includes a hollow annular stent and a plurality of flexible leaflets that are attached to the stent. One or more fixture structures are used to attach the leaflets to the stent so that sutures do not have to be used for that purpose. The fixture structures preferably extend annularly at least substantially all the way around the valve. Surfaces of the fixture structures that can come into contact with portions of the leaflets that move during use of the valve can be shaped to help beneficially shape those leaflet portions during their movements.

摘要翻译： 一种假体心脏瓣膜，其类型包括中空环形支架和附接到支架的多个柔性小叶。 使用一个或多个夹具结构将传单附接到支架上，使得缝合线不必用于该目的。 固定结构优选地至少基本上围绕阀全部地环向延伸。 能够与使用阀门期间移动的小叶的部分接触的夹具结构的表面可以被成形为有助于在移动过程中有利地塑造这些叶片部分。

公开(公告)号：US06562069B2

公开(公告)日：2003-05-13

申请号：US09955703

申请日：2001-09-19

申请人： Chad Q. Cai ,  Steven D. Kruse ,  James L. Kurk ,  Yi-Ren Woo

发明人： Chad Q. Cai ,  Steven D. Kruse ,  James L. Kurk ,  Yi-Ren Woo

IPC分类号： A61F206

CPC分类号： A61F2/2412 ,  A61F2250/0029

摘要： Valved prostheses include a support structure and a plurality of flexible polymer leaflets connected to the support structure, in which the leaflets have an improved structural design. The support structure has a plurality of commissure supports and scallops between the commissure supports. Generally, the flexible polymer leaflets project away from the support structure at an attachment edge where the leaflets connect to the support structure. In particular embodiments, the leaflets at the attachment edge are at an angle from about 5 degrees to about 85 degrees relative to a plane normal to the valve axis. In some embodiments, the flexible polymer leaflets having a coaptation depth from about 0.3 times the valve radius to about 0.8 times the valve radius. In further embodiments, the flexible polymer leaflets form a valve with a valve height from about one times the valve radius to about 2 times the valve radius and have leaflet lengths at least about 1 millimeter greater than the valve radius.

摘要翻译： 带阀的假体包括支撑结构和连接到支撑结构的多个柔性聚合物小叶，其中传单具有改进的结构设计。 支撑结构在连合支撑之间具有多个连合支撑和扇贝。 通常，柔性聚合物小叶在附着边缘处突出远离支撑结构，其中叶片连接到支撑结构。 在特定实施例中，附接边缘处的小叶相对于垂直于阀轴线的平面为约5度至约85度的角度。 在一些实施例中，柔性聚合物小叶具有从阀半径的约0.3倍到阀半径的约0.8倍的接合深度。 在另外的实施例中，柔性聚合物小叶形成阀的高度约为阀半径的大约一倍，大约为阀半径的2倍，并具有比阀半径至少大约1毫米的小叶长度。