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    Polymer leaflet designs for medical devices
    1.
    发明授权
    Polymer leaflet designs for medical devices 有权
    用于医疗器械的聚合物小叶设计

    公开(公告)号：US06562069B2

    公开(公告)日：2003-05-13

    申请号：US09955703

    申请日：2001-09-19

    申请人： Chad Q. Cai ,  Steven D. Kruse ,  James L. Kurk ,  Yi-Ren Woo

    发明人： Chad Q. Cai ,  Steven D. Kruse ,  James L. Kurk ,  Yi-Ren Woo

    IPC分类号： A61F206

    CPC分类号： A61F2/2412 ,  A61F2250/0029

    摘要： Valved prostheses include a support structure and a plurality of flexible polymer leaflets connected to the support structure, in which the leaflets have an improved structural design. The support structure has a plurality of commissure supports and scallops between the commissure supports. Generally, the flexible polymer leaflets project away from the support structure at an attachment edge where the leaflets connect to the support structure. In particular embodiments, the leaflets at the attachment edge are at an angle from about 5 degrees to about 85 degrees relative to a plane normal to the valve axis. In some embodiments, the flexible polymer leaflets having a coaptation depth from about 0.3 times the valve radius to about 0.8 times the valve radius. In further embodiments, the flexible polymer leaflets form a valve with a valve height from about one times the valve radius to about 2 times the valve radius and have leaflet lengths at least about 1 millimeter greater than the valve radius.

    摘要翻译： 带阀的假体包括支撑结构和连接到支撑结构的多个柔性聚合物小叶，其中传单具有改进的结构设计。 支撑结构在连合支撑之间具有多个连合支撑和扇贝。 通常，柔性聚合物小叶在附着边缘处突出远离支撑结构，其中叶片连接到支撑结构。 在特定实施例中，附接边缘处的小叶相对于垂直于阀轴线的平面为约5度至约85度的角度。 在一些实施例中，柔性聚合物小叶具有从阀半径的约0.3倍到阀半径的约0.8倍的接合深度。 在另外的实施例中，柔性聚合物小叶形成阀的高度约为阀半径的大约一倍，大约为阀半径的2倍，并具有比阀半径至少大约1毫米的小叶长度。

    Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
    2.
    发明授权
    Mandrel for use in forming valved prostheses having polymer leaflets by dip coating 有权
    用于通过浸涂形成具有聚合物传单的带瓣假体的心轴

    公开(公告)号：US06953332B1

    公开(公告)日：2005-10-11

    申请号：US09724007

    申请日：2000-11-28

    申请人： James L. Kurk ,  Chad Q. Cai ,  Steven D. Kruse ,  Yi-Ren Woo

    发明人： James L. Kurk ,  Chad Q. Cai ,  Steven D. Kruse ,  Yi-Ren Woo

    IPC分类号： A61F2/24 ,  A61F2/82 ,  B29C33/42 ,  B29C41/14

    CPC分类号： B29C41/14 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0029 ,  B29C33/42 ,  B29L2031/7534 ,  Y10S264/60

    摘要： Improved dip coating methods and mandrels for forming polymer leaflets and valve prostheses generally involve one or more features on the mandrel that facilitate the processing. The mandrel has a top surface and an outer surface comprising a plurality of ridges and contoured surfaces extending to the ridges. An edge on the mandrel separates the top surface and the contoured surfaces, with the mandrel edge corresponding to the free edge of the leaflet. In preferred embodiments, the edge separating the top surface from the contoured surfaces is sharp. The polymer formed on the top surface can be efficiently separated from the remaining portions of the polymer structure to form the free edges of the leaflets.

    摘要翻译： 用于形成聚合物小叶和瓣膜假体的改进的浸涂方法和心轴通常涉及在心轴上的一个或多个特征，其有利于加工。 心轴具有顶表面和外表面，该外表面包括延伸到脊的多个脊和轮廓表面。 心轴上的边缘分离顶表面和轮廓表面，心轴边缘对应于传单的自由边缘。 在优选实施例中，将顶表面与轮廓表面分开的边缘是锋利的。 形成在顶表面上的聚合物可以有效地从聚合物结构的其余部分分离以形成传单的自由边缘。

    Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures
    3.
    发明授权
    Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures 有权
    将假性心脏瓣膜的柔性瓣附接到支撑结构的技术

    公开(公告)号：US08409274B2

    公开(公告)日：2013-04-02

    申请号：US11796471

    申请日：2007-04-26

    申请人： XueMei Li ,  Yi-Ren Woo

    发明人： XueMei Li ,  Yi-Ren Woo

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2409

    摘要： A prosthetic heart valve has an annular valve-perimeter-shape-defining structure having a radially outer surface. A clip structure is provided on the outer surface. This clip structure is used to attach flexible valve leaflets to the shape-defining structure. One or more retainer members may be used to help hold the leaflets in the clip structure.

    摘要翻译： 假体心脏瓣膜具有具有径向外表面的环形阀周边形状限定结构。 夹子结构设置在外表面上。 该夹子结构用于将柔性瓣叶附接到形状限定结构。 可以使用一个或多个保持器构件来帮助将传单保持在夹子结构中。

    Prosthetic heart valves
    4.
    发明授权
    Prosthetic heart valves 有权
    假心脏瓣膜

    公开(公告)号：US07578842B2

    公开(公告)日：2009-08-25

    申请号：US11542903

    申请日：2006-10-03

    申请人： Yi-Ren Woo

    发明人： Yi-Ren Woo

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/42

    摘要： A prosthetic heart valve includes a hydrogel material in its sewing cuff. The hydrogel material may be accompanied by an anticoagulant. If the hydrogel (and/or any included anticoagulant) might react with a packaging solution in which the valve is stored after inclusion of the hydrogel (and any anticoagulant), the hydrogel (and any anticoagulant) may be included in a protective but deliberately frangible pouch in the sewing cuff. After the valve is out of the packaging solution, the pouch can be broken to render the hydrogel (and any coagulant) effective following implantation of the valve in a patient.

    摘要翻译： 假体心脏瓣膜包括其缝合袖口中的水凝胶材料。 水凝胶材料可以伴随有抗凝剂。 如果水凝胶（和/或任何包含的抗凝血剂）可能在包含水凝胶（和任何抗凝血剂）之后与其中储存阀的包装溶液发生反应，则可将水凝胶（和任何抗凝血剂）包含在保护性但故意易碎的 袋缝在袖口。 在阀门脱离包装溶液之后，袋子可以被破坏，使得在将患者植入瓣膜之后使水凝胶（和任何凝结剂）有效。

    Prosthetic heart valves with flexible leaflets
    5.
    发明申请
    Prosthetic heart valves with flexible leaflets 有权
    假性心脏瓣膜带柔性单张

    公开(公告)号：US20080228264A1

    公开(公告)日：2008-09-18

    申请号：US11717305

    申请日：2007-03-12

    申请人： XueMei Li ,  Yi-Ren Woo

    发明人： XueMei Li ,  Yi-Ren Woo

    IPC分类号： A61F2/24 ,  A61B17/08 ,  A61F2/06

    CPC分类号： A61F2/2415

    摘要： A prosthetic heart valve of the type that includes a hollow annular stent and a plurality of flexible leaflets that are attached to the stent. One or more fixture structures are used to attach the leaflets to the stent so that sutures do not have to be used for that purpose. The fixture structures preferably extend annularly at least substantially all the way around the valve. Surfaces of the fixture structures that can come into contact with portions of the leaflets that move during use of the valve can be shaped to help beneficially shape those leaflet portions during their movements.

    摘要翻译： 一种假体心脏瓣膜，其类型包括中空环形支架和附接到支架的多个柔性小叶。 使用一个或多个夹具结构将传单附接到支架上，使得缝合线不必用于该目的。 固定结构优选地至少基本上围绕阀全部地环向延伸。 能够与使用阀门期间移动的小叶的部分接触的夹具结构的表面可以被成形为有助于在移动过程中有利地塑造这些叶片部分。

    Prosthetic heart valves with flexible leaflets and leaflet edge clamping
    7.
    发明授权
    Prosthetic heart valves with flexible leaflets and leaflet edge clamping 有权
    假体心脏瓣膜带有柔性单张和小叶边缘夹紧

    公开(公告)号：US07803186B1

    公开(公告)日：2010-09-28

    申请号：US11906181

    申请日：2007-09-28

    申请人： XueMei Li ,  Yi-Ren Woo

    发明人： XueMei Li ,  Yi-Ren Woo

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0075

    摘要： A prosthetic heart valve includes an annular stent structure having a plurality of annularly spaced stent post regions, a plurality of leaflets that extend radially inward from the stent structure and that include radially outer portions that lie against a radially outer surface of the stent structure, and a clamping structure that is radially outside the other components and that clamps the radially outer portions of the leaflets against the radially outer surface of the stent structures to secure the leaflets to the stent structure. The above-described structural arrangement applies to the stent post regions as well as to other portions of the stent structure.

    摘要翻译： 假体心脏瓣膜包括环形支架结构，其具有多个环形间隔开的支架区域，多个叶片，其从支架结构径向向内延伸并且包括位于支架结构的径向外表面的径向外部部分，以及 夹紧结构，其径向地位于其他部件外部，并将小叶的径向外部部分压靠在支架结构的径向外表面上以将小叶固定到支架结构。 上述结构布置适用于支架支柱区域以及支架结构的其它部分。

    Medical article with a diamond-like carbon coated polymer
    8.
    发明授权
    Medical article with a diamond-like carbon coated polymer 有权
    具有类金刚石碳涂层聚合物的医疗用品

    公开(公告)号：US06761736B1

    公开(公告)日：2004-07-13

    申请号：US09437167

    申请日：1999-11-10

    申请人： Yi-Ren Woo ,  Avrom M. Brendzel ,  Chad Qingshen Cai ,  Stephen A. Peterson

    发明人： Yi-Ren Woo ,  Avrom M. Brendzel ,  Chad Qingshen Cai ,  Stephen A. Peterson

    IPC分类号： A61F224

    CPC分类号： A61L33/025 ,  Y10S977/89

    摘要： Implantable vascular devices and implantable cardiovascular devices suitable for contacting a patient's blood or bodily fluids include a polymer substrate that is at least partly coated with a diamond-like carbon coating. The diamond-like carbon coated polymer substrate can be flexible or rigid. Preferred medical devices include heart valve prostheses with leaflets or orifice rings formed from diamond-like carbon coated polymer materials. Preferred approaches for the deposition of the diamond-like carbon coating are performed at low pressures and include ion beam assisted deposition.

    摘要翻译： 适于接触患者血液或体液的植入式血管装置和可植入的心血管装置包括至少部分地涂覆有类金刚石碳涂层的聚合物基底。 类金刚石碳涂覆的聚合物基材可以是柔性的或刚性的。 优选的医疗装置包括具有由类金刚石碳涂覆的聚合物材料形成的小叶或孔环的心脏瓣膜假体。 用于沉积类金刚石碳涂层的优选方法在低压下进行并且包括离子束辅助沉积。

    Bileaflet valve having non-parallel pivot axes
    9.
    发明授权
    Bileaflet valve having non-parallel pivot axes 有权
    双回流阀具有不平行的枢轴

    公开(公告)号：US6051022A

    公开(公告)日：2000-04-18

    申请号：US224239

    申请日：1998-12-30

    申请人： Qingsheng Cai ,  Yi-Ren Woo

    发明人： Qingsheng Cai ,  Yi-Ren Woo

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2403

    摘要： A bileaflet heart valve prosthesis includes an orifice body or housing defining an orifice or opening for the passage of blood therethrough. First and second leaflets or occluders are disposed in the orifice and pivotally attached to the orifice body. The first and second occluders pivot about axes between an open position and a closed position, and the axes are non-parallel. The orifice is substantially open when the first and second occluders are in their open positions and substantially closed when the occluders are in their closed position. The bileaflet heart valve may be either a central opening valve, or a side opening valve.

    摘要翻译： 双叶心脏瓣膜假体包括孔体或壳体，其限定用于血液通过的孔或开口。 第一和第二小叶或闭塞器设置在孔口中并枢转地附接到孔体上。 第一和第二闭塞器围绕打开位置和关闭位置之间的轴线枢转，并且轴线是不平行的。 当第一和第二封堵器处于其打开位置时，孔口基本打开，并且当封堵器处于其闭合位置时，孔口基本上封闭。 双叶心脏瓣膜可以是中心开启阀或侧开式阀。