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1.发明申请公开(公告)号：US20100022535A1
公开(公告)日：2010-01-28
申请号：US12457479
申请日：2009-06-11
Applicant: Ju Young Lee , Jae-Sun Kim , Jung-Hoon Oh , Hoe-chul Jung , Hyun Jung Lee , Sang-hwan Kang , Yong-Hyuk Kim , Sung-hoon Park , Keun-Ho Ryu , Jung Bum Yi , Hun-Taek Kim , Key-An Um , Bong-yong Lee
Inventor： Ju Young Lee , Jae-Sun Kim , Jung-Hoon Oh , Hoe-chul Jung , Hyun Jung Lee , Sang-hwan Kang , Yong-Hyuk Kim , Sung-hoon Park , Keun-Ho Ryu , Jung Bum Yi , Hun-Taek Kim , Key-An Um , Bong-yong Lee
IPC: A61K31/5377 , A61K31/498 , A61K31/4709 , C07D413/14 , C07D401/14
CPC classification number: C04B35/632 , C07D401/14
Abstract: 2-pyridyl-substituted imidazoles which are used advantageously in the treatment of diseases mediated by ALK 5 or ALK 4 inhibitors or both.
Abstract translation: 2-吡啶基取代的咪唑，其有利地用于治疗由ALK 5或ALK 4抑制剂或两者所介导的疾病。
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2.发明申请PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME 有权吡啶酰胺和嘧啶-4-羧酰胺化合物，其制备方法和包含其的药物组合物公开(公告)号：US20130210811A1
公开(公告)日：2013-08-15
申请号：US13696400
申请日：2011-05-04
Applicant: Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
Inventor： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
IPC: C07D401/04 , C07D403/14 , C07D403/04 , C07D401/14 , C07D405/14
CPC classification number: C07D401/04 , C07D213/81 , C07D239/557 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
Abstract: Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
Abstract translation: 提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途 化合物对11beta-HSD1酶的选择性抑制活性。 本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11beta-HSD1酶的选择性抑制剂，可用于预防，调节和治疗与糖皮质激素调节相关的疾病的药剂，其中人源性11β- 涉及HSD1酶，例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成年（LADA），胰岛素耐受综合征，肥胖症，葡萄糖耐量异常（IGT），空腹血糖受损（IFG ），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。
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3.发明申请2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS 审中-公开2-PYRIDYL取代的咪唑烷作为ALK5和/或ALK4抑制剂公开(公告)号：US20130018052A1
公开(公告)日：2013-01-17
申请号：US13548785
申请日：2012-07-13
Applicant: Ju Young LEE , Keun-Ho RYU , Jae-Sun KIM , Yong-Hyuk KIM , Dong Chul SHIN , Bong-yong LEE , Sang-hwan KANG , Hyun-Jung LEE , Hoechul JUNG , Young Ah SHIN , Euisun PARK , Jaeseung AHN
Inventor： Ju Young LEE , Keun-Ho RYU , Jae-Sun KIM , Yong-Hyuk KIM , Dong Chul SHIN , Bong-yong LEE , Sang-hwan KANG , Hyun-Jung LEE , Hoechul JUNG , Young Ah SHIN , Euisun PARK , Jaeseung AHN
IPC: A61K31/444 , A61K31/498 , A61K31/519 , A61K31/4709 , C07D495/04 , A61K31/4439 , C07D498/04 , A61P13/12 , A61P1/16 , A61P11/00 , A61P9/04 , A61P9/00 , A61P27/02 , A61P9/10 , A61P17/02 , A61P19/02 , A61P19/10 , A61P25/00 , A61P15/00 , A61P17/00 , A61P25/28 , A61P7/02 , A61P35/00 , A61P35/04 , C07D487/04
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.
Abstract translation: 本发明提供了选择性抑制转化生长因子-β1的新型2-吡啶基取代咪唑衍生物或其药学上可接受的盐或溶剂合物。 （TGF-β）I型受体（ALK5）和/或激活素I型受体（ALK4）; 包含其作为活性成分的药物组合物; 以及2-吡啶基取代的咪唑衍生物在制备用于预防或治疗由哺乳动物中ALK5和/或ALK4受体介导的疾病的药物中的用途。
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4.发明申请QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY 审中-公开用于治疗和预防糖尿病和肥胖的喹诺酮衍生物公开(公告)号：US20080207614A1
公开(公告)日：2008-08-28
申请号：US11772098
申请日：2007-06-29
Applicant: Nam Kyu Lee , Jun Won Lee , Sukho Lee , Guang-Jin Im , Hye Young Han , Tae Kon Kim , Yong Hyuk Kim , Wie-Jong Kwak , Sang Woong Kim , Joohun Ha , Eon Kyum Kim , Jung Kyu Lee , Choong Yeul Yoo , Dae Yeon Lee
Inventor： Nam Kyu Lee , Jun Won Lee , Sukho Lee , Guang-Jin Im , Hye Young Han , Tae Kon Kim , Yong Hyuk Kim , Wie-Jong Kwak , Sang Woong Kim , Joohun Ha , Eon Kyum Kim , Jung Kyu Lee , Choong Yeul Yoo , Dae Yeon Lee
IPC: A61K31/517 , A61P3/10 , C07D239/72 , C07D413/02 , C07D401/02 , C07D239/86 , A61P3/04
CPC classification number: C07D239/91 , C07D239/93 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: The present invention relates to novel quinazoline derivatives effective in lowering blood glucose level and body weight, and a medicine for treatment and/or prevention of diabetes and/or obesity, which comprises the compound as an active ingredient.
Abstract translation: 本发明涉及有效降低血糖水平和体重的新型喹唑啉衍生物，以及用于治疗和/或预防糖尿病和/或肥胖症的药物，其包含该化合物作为活性成分。
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Patent Agency Ranking
5.发明授权Method for fabricating a DRAM cell capacitor using hemispherical grain (HSG) silicon 有权使用半球形晶粒（HSG）硅制造DRAM单元电容器的方法公开(公告)号：US06300192B1
公开(公告)日：2001-10-09
申请号：US09458462
申请日：1999-12-09
Applicant: Yong-Hyuk Kim
Inventor： Yong-Hyuk Kim
IPC: H01L218242
CPC classification number: H01L28/84 , H01L27/10852
Abstract: A stacked DRAM cell capacitor having HSG silicon only on a top portion of a storage node, not on a bottom portion thereof. The storage node has a double layer structure including a bottom layer and a top layer. The bottom layer is made of a conductive material that suppresses the growth of HSG seeds. Accordingly, electrical bridges between adjacent storage nodes, particularly at a bottom portion, can be prevented.
Abstract translation: 具有HSG硅的层叠DRAM单元电容器仅在存储节点的顶部上而不在其底部。 存储节点具有包括底层和顶层的双层结构。 底层由抑制HSG种子生长的导电材料制成。 因此，可以防止相邻存储节点之间，特别是底部的电桥。
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6.发明授权公开(公告)号：US08410146B2
公开(公告)日：2013-04-02
申请号：US12457479
申请日：2009-06-11
Applicant: Ju Young Lee , Jae-Sun Kim , Jung-Hoon Oh , Hoe-chul Jung , Hyun Jung Lee , Sang-hwan Kang , Yong-Hyuk Kim , Sung-hoon Park , Keun-Ho Ryu , Jung Bum Yi , Hun-Taek Kim , Key-An Um , Bong-yong Lee
Inventor： Ju Young Lee , Jae-Sun Kim , Jung-Hoon Oh , Hoe-chul Jung , Hyun Jung Lee , Sang-hwan Kang , Yong-Hyuk Kim , Sung-hoon Park , Keun-Ho Ryu , Jung Bum Yi , Hun-Taek Kim , Key-An Um , Bong-yong Lee
IPC: A61K31/44
CPC classification number: C04B35/632 , C07D401/14
Abstract: 2-pyridyl substituted imidazoles of the formula (I) as shown in claim 1, are provided, which are useful in the treatment of diseases mediated by ALK5 or ALK4 inhibitors or both.
Abstract translation: 提供了如权利要求1所述的式（I）的2-吡啶基取代的咪唑，其可用于治疗由ALK5或ALK4抑制剂或两者介导的疾病。
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7.发明授权Method for fabricating a DRAM cell capacitor using hemispherical grain (HSG) silicon 有权使用半球形晶粒（HSG）硅制造DRAM单元电容器的方法公开(公告)号：US06700148B2
公开(公告)日：2004-03-02
申请号：US09935001
申请日：2001-08-21
Applicant: Yong-Hyuk Kim
Inventor： Yong-Hyuk Kim
IPC: H01L27108
CPC classification number: H01L28/84 , H01L27/10852
Abstract: A stacked DRAM cell capacitor having HSG silicon only on a top portion of a storage node, not on a bottom portion thereof. The storage node has a double layer structure including a bottom layer and a top layer. The bottom layer is made of a conductive material that suppresses the growth of HSG seeds. Accordingly, electrical bridges between adjacent storage nodes, particularly at a bottom portion, can be prevented.
Abstract translation: 具有HSG硅的层叠DRAM单元电容器仅在存储节点的顶部上而不在其底部。 存储节点具有包括底层和顶层的双层结构。 底层由抑制HSG种子生长的导电材料制成。 因此，可以防止相邻存储节点之间，特别是底部的电桥。
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公开(公告)号：US10155763B2
公开(公告)日：2018-12-18
申请号：US13548785
申请日：2012-07-13
Applicant: Ju Young Lee , Keun-Ho Ryu , Jae-Sun Kim , Yong-Hyuk Kim , Dong-Chul Shin , Bong-yong Lee , Sang-hwan Kang , Hyun-Jung Lee , Hoechul Jung , Young Ah Shin , Euisun Park , Jaeseung Ahn , Hun-Taek Kim , Je Ho Ryu
Inventor： Ju Young Lee , Keun-Ho Ryu , Jae-Sun Kim , Yong-Hyuk Kim , Dong-Chul Shin , Bong-yong Lee , Sang-hwan Kang , Hyun-Jung Lee , Hoechul Jung , Young Ah Shin , Euisun Park , Jaeseung Ahn , Hun-Taek Kim , Je Ho Ryu
IPC: C07D487/04 , C07D519/00
Abstract: The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.
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9.发明授权Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same 有权吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法和包含其的药物组合物公开(公告)号：US09096571B2
公开(公告)日：2015-08-04
申请号：US13696400
申请日：2011-05-04
Applicant: Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
Inventor： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
IPC: A61K31/47 , A61K31/55 , A61K31/445 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D213/81 , C07D401/06 , C07D401/12 , C07D405/12 , C07D239/557
CPC classification number: C07D401/04 , C07D213/81 , C07D239/557 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
Abstract: Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
Abstract translation: 提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途 该化合物对于11-bgr-HSD1酶的选择性抑制活性。 本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11β-HSD1酶的选择性抑制剂，可用于预防，调节和治疗糖皮质激素调节相关疾病的药剂，其中人源性11β- ; -HSD1酶涉及例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成人（LADA），胰岛素耐受综合征，肥胖，葡萄糖耐量异常（IGT），空腹血糖受损 （IFG），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。
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