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公开(公告)号：US09334281B2
公开(公告)日：2016-05-10
申请号：US12231988
申请日：2008-09-08
申请人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
发明人： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
IPC分类号： C07C211/61 , C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07D213/74 , C07D295/135 , C07F9/53 , C07F9/6503 , C09B1/00 , C09B1/51 , C09B1/515 , C40B40/04 , G01N33/50
CPC分类号： C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07C2603/24 , C07D213/74 , C07D295/135 , C07F9/5304 , C07F9/65038 , C09B1/005 , C09B1/51 , C09B1/512 , C09B1/5155 , C40B40/04 , G01N33/5005 , G01N33/5011
摘要： Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
摘要翻译： 提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。 这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。
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公开(公告)号：US08715944B2
公开(公告)日：2014-05-06
申请号：US12287882
申请日：2008-10-13
IPC分类号： G01N33/53 , G01N33/567 , C07C211/00 , C07C223/00 , C07C221/00
CPC分类号： G01N33/5076 , C07C225/34 , C07C225/36 , C07C2603/24 , G01N33/582
摘要： Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
摘要翻译： 提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。 这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。
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公开(公告)号：US20100093004A1
公开(公告)日：2010-04-15
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。 可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。 药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。 还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。
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公开(公告)号：US09250249B2
公开(公告)日：2016-02-02
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。 可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。 药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。 还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。
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5.发明授权Methods for detecting the presence, location or quantity of targets using novel dyes 有权使用新型染料检测靶的存在，位置或数量的方法公开(公告)号：US08389729B2
公开(公告)日：2013-03-05
申请号：US12456503
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C07D215/44
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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6.发明授权Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules 有权与靶分子连接的染料，包含染料分子的寡核苷酸或多核苷酸，复合染料和可用于检测或定量所需靶分子的其它组合物公开(公告)号：US08153802B2
公开(公告)日：2012-04-10
申请号：US12456502
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Elazar Rabbani , Rajesh Khazanchi , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Elazar Rabbani , Rajesh Khazanchi , Dakai Liu , Wei Cheng
IPC分类号： C07D215/44 , C07D401/02
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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7.发明申请Novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes - useful or detection or quantification of desirable target molecules 有权新型染料，复合染料和寡核苷酸或包含这种染料的多核苷酸 - 可用或检测或定量所需的靶分子公开(公告)号：US20130045480A1
公开(公告)日：2013-02-21
申请号：US12456515
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C07D417/14 , C07D277/64 , C07D417/12 , G01N21/76 , C07H21/00 , C07K16/00 , C07K17/02 , C12N9/96 , C07K14/575 , C07K14/52 , C07H15/26 , C08B37/00 , C12N1/20 , C07F7/02 , C07D455/04
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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8.发明申请Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes 有权用于检测或定量所需靶分子，新染料，复合染料和寡核苷酸的组合物或包含这些染料的多核苷酸公开(公告)号：US20120040430A1
公开(公告)日：2012-02-16
申请号：US12456513
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C09B23/10
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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9.发明申请Methods for detecting the presence, location or quantity of targets using novel dyes 有权使用新型染料检测靶的存在，位置或数量的方法公开(公告)号：US20100041020A1
公开(公告)日：2010-02-18
申请号：US12456503
申请日：2009-06-17
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： G01N33/566 , G01N33/573 , C12Q1/70 , C12Q1/02 , G01N33/567 , C12Q1/68
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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公开(公告)号：US07569695B2
公开(公告)日：2009-08-04
申请号：US11137771
申请日：2005-05-24
申请人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
发明人： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC分类号： C07D417/04
CPC分类号： C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
摘要翻译： 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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