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1.发明授权Detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes 有权检测或定量所需的靶分子，新型染料，复合染料和寡核苷酸或包含这些染料的多核苷酸公开(公告)号：US08846952B2
公开(公告)日：2014-09-30
申请号：US12456514
申请日：2009-06-17
Applicant: Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
Inventor： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC: C07D209/14 , C07D235/20 , C07D277/68 , C07D263/54 , C07D417/14 , C07D401/14 , C07D405/14 , C07D417/06 , C09B23/01 , C09B23/04 , C09B23/06 , C09B23/08 , C09B23/10 , C09B23/14 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00
CPC classification number: C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
Abstract translation: 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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公开(公告)号：US08778614B2
公开(公告)日：2014-07-15
申请号：US12806950
申请日：2010-08-24
Applicant: Elazar Rabbani , Joshua Rabbani , Praveen Pande , Jannis G. Stavrianopoulos
Inventor： Elazar Rabbani , Joshua Rabbani , Praveen Pande , Jannis G. Stavrianopoulos
IPC: G01N33/53
CPC classification number: G01N33/6803 , C12Q1/485 , C12Y207/01091 , C12Y207/11001 , G01N33/92 , G01N2405/08 , G01N2410/00 , G01N2440/14 , G01N2440/30
Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
Abstract translation: 提供的方法和组合物可用于分离，分离，检测和定量已经由尚未被这样修饰的其它化合物化学，酶促或催化改性的化合物。 这些修饰可以采取由感兴趣的化合物获得，丢失或保留的官能团的形式。
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3.发明授权Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes 有权用于检测或定量所需靶分子，新染料，复合染料和寡核苷酸的组合物或包含这些染料的多核苷酸公开(公告)号：US08574881B2
公开(公告)日：2013-11-05
申请号：US12456513
申请日：2009-06-17
Applicant: Praveen Pande , Yuejun Xiang , Elazar Rabbani
Inventor： Praveen Pande , Yuejun Xiang , Elazar Rabbani
IPC: C09B23/10
CPC classification number: C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
Abstract translation: 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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公开(公告)号：US08445271B2
公开(公告)日：2013-05-21
申请号：US12799853
申请日：2010-05-03
Applicant: Irina Lebedeva , Praveen Pande , Wayne Forrest Patton
Inventor： Irina Lebedeva , Praveen Pande , Wayne Forrest Patton
IPC: C12N15/00
CPC classification number: G01N21/6486 , G01N33/502 , G01N2800/44
Abstract: This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDR1, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.
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5.发明申请Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules 有权与靶分子连接的染料，包含染料分子的寡核苷酸或多核苷酸，复合染料和可用于检测或定量所需靶分子的其它组合物公开(公告)号：US20100228008A1
公开(公告)日：2010-09-09
申请号：US12456502
申请日：2009-06-17
Applicant: Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
Inventor： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC: C07K16/00 , C07D487/06 , C07D215/06 , C07D417/14 , C07D401/14 , C07H21/02 , C07D277/64 , C07F9/40
CPC classification number: C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
Abstract translation: 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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Patent Agency Ranking
6.发明申请Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest 有权新型荧光染料和化合物，用于鉴定特定细胞器和感兴趣的细胞中的区域的方法和试剂盒公开(公告)号：US20100068752A1
公开(公告)日：2010-03-18
申请号：US12586386
申请日：2009-09-21
Applicant: Praveen Pande , Hilary J. Cox , Yuejun Xiang , Wayne Forrest Patton
Inventor： Praveen Pande , Hilary J. Cox , Yuejun Xiang , Wayne Forrest Patton
IPC: C12Q1/02 , C07F9/60 , C07F9/6533 , C07F9/6509 , C07D401/10 , C07D215/04
CPC classification number: G01N21/6486 , B82Y30/00 , C07D215/12 , C07D215/14 , C07D401/14 , C07D405/14 , C07D417/06 , C07D417/14 , C09B23/145 , G01N33/533 , G01N33/582 , Y10T436/16
Abstract: The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been substituted with specific groups to provide beneficial properties.
Abstract translation: 本发明提供可用于检测或定量所需靶分子如蛋白质，核酸和细胞器的染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 在本发明中提供的染料可以包含反应性基团，其可以用于将染料连接到将与所需靶分子结合的探针上。 本发明的新型染料已经被特定的基团取代以提供有益的性质。
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7.发明申请公开(公告)号：US20060269926A1
公开(公告)日：2006-11-30
申请号：US11137771
申请日：2005-05-24
Applicant: Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
Inventor： Yuejun Xiang , Praveen Pande , Rajesh Khazanchi , Elazar Rabbani , Dakai Liu , Wei Cheng
IPC: C12Q1/70 , C12Q1/68 , C07K16/46 , C07K14/705 , C07K14/52 , C07K14/575 , C07J17/00 , C07J43/00 , C07D419/02
CPC classification number: C07D417/14 , C07D209/14 , C07D235/20 , C07D401/14 , C07D405/14 , C07D417/06 , C07H19/10 , C07H21/00 , C07K14/00 , C07K16/00 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146
Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.
Abstract translation: 本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 通过加入带电极和极性基团来改进本发明的新型染料以提供有益的性质。
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公开(公告)号：US09334281B2
公开(公告)日：2016-05-10
申请号：US12231988
申请日：2008-09-08
Applicant: Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
Inventor： Wayne Forrest Patton , Praveen Pande , Yuejun Xiang , Zaiguo Li , James J. Donegan , Elazar Rabbani
IPC: C07C211/61 , C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07D213/74 , C07D295/135 , C07F9/53 , C07F9/6503 , C09B1/00 , C09B1/51 , C09B1/515 , C40B40/04 , G01N33/50
CPC classification number: C07D487/06 , C07C225/34 , C07C225/36 , C07C229/18 , C07C335/20 , C07C2603/24 , C07D213/74 , C07D295/135 , C07F9/5304 , C07F9/65038 , C09B1/005 , C09B1/51 , C09B1/512 , C09B1/5155 , C40B40/04 , G01N33/5005 , G01N33/5011
Abstract: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
Abstract translation: 提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。 这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。
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9.发明授权Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications 有权染料和组合物，以及在蛋白质聚集和其他应用的分析中使用它们的方法公开(公告)号：US09133343B2
公开(公告)日：2015-09-15
申请号：US12592639
申请日：2009-11-30
Applicant: Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda
Inventor： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda
IPC: C07D251/00 , C07D471/00 , C07D213/00 , B01L3/00 , G03C5/00 , C09B23/14 , C07H19/04
CPC classification number: C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
Abstract: Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.
Abstract translation: 提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析 。 这些染料和组合物也可用作核酸和蛋白质检测中的探针。
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公开(公告)号：US08715944B2
公开(公告)日：2014-05-06
申请号：US12287882
申请日：2008-10-13
Applicant: Praveen Pande , Yuejun Xiang , Wayne Forrest Patton
Inventor： Praveen Pande , Yuejun Xiang , Wayne Forrest Patton
IPC: G01N33/53 , G01N33/567 , C07C211/00 , C07C223/00 , C07C221/00
CPC classification number: G01N33/5076 , C07C225/34 , C07C225/36 , C07C2603/24 , G01N33/582
Abstract: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
Abstract translation: 提供了用于在感兴趣细胞中鉴定细胞器的化合物，方法和试剂盒，包括细胞核和除核以外的多种细胞器（非核细胞器）以及细胞区域或细胞结构域。 这些化合物和方法可以与其它常规检测试剂一起使用，用于鉴定细胞器的位置或位置，甚至用于鉴别感兴趣的细胞中的细胞器。
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