公开(公告)号：US20130005710A1

公开(公告)日：2013-01-03

申请号：US13509668

申请日：2010-11-17

申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Norihito Tokunaga ,  Yuhei Miyanohana

发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Norihito Tokunaga ,  Yuhei Miyanohana

IPC分类号： A61K31/496 ,  A61K31/5377 ,  C07D417/14 ,  C07D401/04 ,  A61P25/28 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/551 ,  C07D413/14 ,  C07D409/14 ,  C07D413/04 ,  C07D401/14

CPC分类号： C07D213/74 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  C07D213/76 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04

摘要： The present invention provides a novel aminopyridine derivative that is excellent in pharmaceutical effects such as a neuroprotective effect, a neurogenesis or nerve regeneration promoting effect, and a cognitive function improving effect and, preferably, is low toxic and delivered at a high rate to the central nervous system. Specifically, the present invention provides a compound represented by the formula (I), wherein ring A represents a monocyclic aromatic hydrocarbon ring or the like; ring B may further have a substituent(s); ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, or a methylene group or the like; X represents —NRa- or the like, wherein Ra represents a hydrogen atom or the like; n represents 1 or 2; and R1 to R3 each represent a hydrogen atom or the like, wherein ring A and ring D each may be condensed with another ring to form a condensed ring which may have a substituent(s), and ring A-L- in the formula (I) may be bonded to X, provided that when ring A is pyrazole which may be substituted and ring D is benzene which may be substituted, L is a bond; or a salt thereof.

摘要翻译： 本发明提供一种新颖的氨基吡啶衍生物，其具有优异的药效，如神经保护作用，神经发生或神经再生促进作用，以及认知功能改善作用，优选为低毒性，高速递送至中枢 神经系统。 具体地，本发明提供式（I）表示的化合物，其中环A表示单环芳香烃环等; 环B还可以具有取代基; 环D表示单环芳香烃环等; L表示键或亚甲基等; X表示-NR a等，其中R a表示氢原子等; n表示1或2; 并且R 1至R 3各自表示氢原子等，其中环A和环D各自可与另一个环缩合形成可具有取代基的稠环，式（I）中的环 - 可以与X键合，条件是当环A是可被取代的吡唑时，环D是可被取代的苯，L是一个键; 或其盐。

公开(公告)号：US20110130384A1

公开(公告)日：2011-06-02

申请号：US13000570

申请日：2009-06-24

申请人： Masaki Setoh ,  Yuhei Miyanohana ,  Mitsunori Kouno

发明人： Masaki Setoh ,  Yuhei Miyanohana ,  Mitsunori Kouno

IPC分类号： A61K31/55 ,  C07D209/04 ,  A61K31/4045 ,  C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  A61K31/519 ,  C07D223/16 ,  A61P25/18

CPC分类号： C07D209/08 ,  C07C233/65 ,  C07C233/78 ,  C07C235/16 ,  C07C235/42 ,  C07C235/48 ,  C07C237/22 ,  C07C237/32 ,  C07C237/34 ,  C07C255/29 ,  C07C317/28 ,  C07C323/42 ,  C07C2601/02 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/10 ,  C07D209/18 ,  C07D213/81 ,  C07D223/16 ,  C07D231/56 ,  C07D265/36 ,  C07D277/20 ,  C07D277/46 ,  C07D307/14 ,  C07D307/82 ,  C07D311/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： The present invention aims to provide a prophylactic or therapeutic agent for schizophrenia and the like, containing the compound of the present invention having a GPR52 agonist activity. A compound represented by the following formula (I) or a salt thereof: wherein, A is —CONH or the like, B is a hydrogen atom or a substituent, ring Cy1 is a benzene ring or the like, X1, X2 and X3 are each independently —CH═ or —N═ or the like, ring Cy2 is a carbon ring or the like, Z is a carbon atom or a nitrogen atom, L is a bond or the like, n is 1 or 2, Rb is a hydrogen atom or a substituent, and ring Cy3 is a benzene ring or the like.

摘要翻译： 本发明旨在提供含有具有GPR52激动剂活性的本发明化合物的精神分裂症等的预防或治疗剂。 由下式（I）表示的化合物或其盐：其中A为-CONH等，B为氢原子或取代基，环为Cy1为苯环等，X1，X2，X3为 各自独立地为-CH =或-N =等，环Cy2为碳环等，Z为碳原子或氮原子，L为键等，n为1或2，Rb为 氢原子或取代基，环Cy3为苯环等。

公开(公告)号：US20100041891A1

公开(公告)日：2010-02-18

申请号：US12539559

申请日：2009-08-11

申请人： Masaki Setoh ,  Mitsunori Kouno ,  Yuhei Miyanohana ,  Masakuni Kori

发明人： Masaki Setoh ,  Mitsunori Kouno ,  Yuhei Miyanohana ,  Masakuni Kori

IPC分类号： C07D409/06 ,  C07D235/24 ,  C07D277/62

CPC分类号： C07D217/04 ,  C07D209/10 ,  C07D209/46 ,  C07D231/56 ,  C07D235/10 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30 ,  C07D263/56 ,  C07D277/64 ,  C07D277/68 ,  C07D307/79 ,  C07D333/54 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048

摘要： A compound having GPR52 agonist activity or a salt thereof is provided.The compound can be provided as a preventive/therapeutic agent for schizophrenia or the like. The compound is represented by the following formula: whereinA represents —CONRa— or —NRaCO—, Ra represents a hydrogen atom or the like, B represents a hydrogen atom or the like, a ring Cy1 represents a six-membered aromatic ring which may have one or more substituents in addition to a group represented by -A-B, a ring Cy2 represents a six-membered ring which may be substituted with a halogen atom or the like, a ring Cy3 represents a five- or six-membered ring which may have one or more substituents; X represents C1-2 alkylene or the like, m represents an integer of 0 to 2, and a ring Cy4 represents a six-membered aromatic ring which may have one or more substituents.

摘要翻译： 提供具有GPR52激动剂活性的化合物或其盐。 该化合物可以作为精神分裂症等的预防/治疗剂提供。 该化合物由下式表示：其中A表示-CONRa-或-NRaCO-，Ra表示氢原子等，B表示氢原子等，环Cy1表示可以含有六元芳环的六元芳环 除了由-AB表示的基团之外还具有一个或多个取代基，环Cy2表示可被卤素原子等取代的六元环，环Cy3表示五元或六元环，其可以 具有一个或多个取代基; X表示C1-2亚烷基等，m表示0〜2的整数，环Cy4表示可具有一个以上取代基的六元芳香环。