公开(公告)号：US07709242B2

公开(公告)日：2010-05-04

申请号：US12337016

申请日：2008-12-17

申请人： Atsuko Takai ,  Ranko Nishi ,  Yuji Joe ,  Hisao Ito

发明人： Atsuko Takai ,  Ranko Nishi ,  Yuji Joe ,  Hisao Ito

IPC分类号： C12N1/20

CPC分类号： C12P13/225 ,  C12N9/001 ,  C12N9/90

摘要： The present invention describes the production of L-tyrosine by culturing in a medium an Escherichia bacterium which has L-tyrosine-producing ability and which carries a mutant prephenate dehydrogenase which is desensitized to feedback inhibition by L-tyrosine, producing and accumulating L-tyrosine in the medium or in the bacterial cells, and collecting L-tyrosine from the medium or the bacterial cells.

摘要翻译： 本发明描述了通过在具有L-酪氨酸生产能力的大肠杆菌细菌培养基中培养L-酪氨酸，并携带脱敏的L-突变型预苯酸脱氢酶以产生和积累L-酪氨酸 在培养基或细菌细胞中，并从培养基或细菌细胞中收集L-酪氨酸。

公开(公告)号：US20090275090A1

公开(公告)日：2009-11-05

申请号：US12056390

申请日：2008-03-27

申请人： Takuji Ueda ,  Yuji Joe

发明人： Takuji Ueda ,  Yuji Joe

IPC分类号： C12P13/14 ,  C12P13/04 ,  C12P13/08

CPC分类号： C12P13/04 ,  C12P13/08 ,  C12P13/14

摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the medium or cells.

摘要翻译： 提供一种L-氨基酸的制造方法，其包括在培养基中培养具有产生L-氨基酸的能力的肠杆菌科的微生物，并且其被改性以增强β-葡糖苷PTS活性， 并从培养基或细胞中收集L-氨基酸。

公开(公告)号：US20090104683A1

公开(公告)日：2009-04-23

申请号：US12337016

申请日：2008-12-17

申请人： Atsuko Takai ,  Ranko Nishi ,  Yuji Joe ,  Hisao Ito

发明人： Atsuko Takai ,  Ranko Nishi ,  Yuji Joe ,  Hisao Ito

IPC分类号： C12N1/21

CPC分类号： C12P13/225 ,  C12N9/001 ,  C12N9/90

摘要： The present invention describes the production of L-tyrosine by culturing in a medium an Escherichia bacterium which has L-tyrosine-producing ability and which carries a mutant prephenate dehydrogenase which is desensitized to feedback inhibition by L-tyrosine, producing and accumulating L-tyrosine in the medium or in the bacterial cells, and collecting L-tyrosine from the medium or the bacterial cells.

摘要翻译： 本发明描述了通过在具有L-酪氨酸生产能力的大肠杆菌细菌培养基中培养L-酪氨酸，并携带脱敏的L-突变型预苯酸脱氢酶以产生和积累L-酪氨酸 在培养基或细菌细胞中，并从培养基或细菌细胞中收集L-酪氨酸。

公开(公告)号：US20090087887A1

公开(公告)日：2009-04-02

申请号：US12241233

申请日：2008-09-30

申请人： Saori Kataoka ,  Takuji Ueda ,  Yuji Joe ,  Chie Koseki

发明人： Saori Kataoka ,  Takuji Ueda ,  Yuji Joe ,  Chie Koseki

IPC分类号： C12P13/04 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/22 ,  C12P13/06

CPC分类号： C12P13/04 ,  C12N9/93

摘要： An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the acetyl-CoA synthetase activity is increased.

摘要翻译： L-氨基酸是通过培养属于肠杆菌科的L-氨基酸产生菌而进行的，其被修饰以使乙酰辅酶A合成酶活性增加。

公开(公告)号：US07300776B2

公开(公告)日：2007-11-27

申请号：US11113270

申请日：2005-04-25

申请人： Hisao Ito ,  Yuji Joe

发明人： Hisao Ito ,  Yuji Joe

IPC分类号： C12P13/04 ,  C12P13/24 ,  C12P13/22 ,  C12P13/14 ,  C12N9/10 ,  C12N1/21 ,  C07H21/04

CPC分类号： C12N1/20 ,  C12P13/08 ,  C12P13/12 ,  C12P13/14 ,  C12P13/22 ,  C12P13/24

摘要： An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group consisting of L-tryptophan, L-phenylalanine, L-lysine, L-tyrosine, L-glutamic acid, L-histidine, L-cysteine, and L-proline.

摘要翻译： 通过改变大肠杆菌K12菌株或其衍生物以使其变得对L-缬氨酸具有抗性并且具有产生一种或多种选自下组的L-氨基酸的能力来培育大肠杆菌的L-氨基酸生产菌株 由L-色氨酸，L-苯丙氨酸，L-赖氨酸，L-酪氨酸，L-谷氨酸，L-组氨酸，L-半胱氨酸和L-脯氨酸组成。

公开(公告)号：US07871801B2

公开(公告)日：2011-01-18

申请号：US12056414

申请日：2008-03-27

申请人： Takuji Ueda ,  Yuji Joe

发明人： Takuji Ueda ,  Yuji Joe

IPC分类号： C12P13/04 ,  C12N9/00 ,  C12N9/24 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12P13/14 ,  C12P13/04 ,  C12P13/08

摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium or in cells, and collecting the L-amino acid from the medium or cells.

摘要翻译： 提供L-氨基酸的制造方法，其包括在培养基中培养具有生产L-氨基酸的能力的肠杆菌科的微生物，并且已经被改性以提高甘露糖PTS活性， 培养基或细胞中的L-氨基酸，并从培养基或细胞中收集L-氨基酸。

公开(公告)号：US08383363B1

公开(公告)日：2013-02-26

申请号：US11759419

申请日：2007-06-07

申请人： Takuji Ueda ,  Yuta Nakai ,  Yoshiya Gunji ,  Rie Takikawa ,  Yuji Joe

发明人： Takuji Ueda ,  Yuta Nakai ,  Yoshiya Gunji ,  Rie Takikawa ,  Yuji Joe

IPC分类号： C12P1/00 ,  C12P1/04 ,  C12P13/08 ,  C12P13/10

CPC分类号： C12P13/10 ,  C07K14/245 ,  C12P13/04 ,  C12P13/08

摘要： L-amino acids are produced by culturing a microorganism which has an ability to produce the L-amino acid, but has been modified so that expression of the ybjE gene has been enhanced. The L-amino acid is collected from the culture medium or from the microorganism.

公开(公告)号：US08354255B2

公开(公告)日：2013-01-15

申请号：US12056390

申请日：2008-03-27

申请人： Takuji Ueda ,  Yuji Joe

发明人： Takuji Ueda ,  Yuji Joe

IPC分类号： C12P13/14 ,  C12P13/04 ,  C12P13/08

CPC分类号： C12P13/04 ,  C12P13/08 ,  C12P13/14

摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the medium or cells.

摘要翻译： 提供了一种L-氨基酸的制造方法，其包括在培养基中培养具有产生L-氨基酸的能力的肠杆菌科的微生物，并且其被修饰以增强葡萄糖苷的PTS活性 并从培养基或细胞中收集L-氨基酸。

公开(公告)号：US20090275091A1

公开(公告)日：2009-11-05

申请号：US12056414

申请日：2008-03-27

申请人： Takuji Ueda ,  Yuji Joe

发明人： Takuji Ueda ,  Yuji Joe

IPC分类号： C12P13/04 ,  C12P13/08 ,  C12P13/14

CPC分类号： C12P13/14 ,  C12P13/04 ,  C12P13/08

摘要： A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium or in cells, and collecting the L-amino acid from the medium or cells.

摘要翻译： 提供L-氨基酸的制造方法，其包括在培养基中培养具有生产L-氨基酸的能力的肠杆菌科的微生物，并且已经被改性以提高甘露糖PTS活性， 培养基或细胞中的L-氨基酸，并从培养基或细胞中收集L-氨基酸。

公开(公告)号：US20060160191A1

公开(公告)日：2006-07-20

申请号：US11275562

申请日：2006-01-17

申请人： Saori Kataoka ,  Yuuta Nakai ,  Takuji Ueda ,  Yuji Joe ,  Hisao Ito

发明人： Saori Kataoka ,  Yuuta Nakai ,  Takuji Ueda ,  Yuji Joe ,  Hisao Ito

IPC分类号： C12P13/04 ,  C12P13/14 ,  C12P13/08 ,  C12N1/21

CPC分类号： C07K14/245 ,  C12N15/70 ,  C12P13/04 ,  C12P13/08 ,  C12P13/14

摘要： An L-amino acid producing bacterium of the Enterobacteriaceae family is described, wherein the bacterium has been modified so as to not produce type I fimbrial adhesin protein is cultured in a medium to produce and excrete said L-amino acid in the medium, and collecting said L-amino acid from the medium.

摘要翻译： 描述了肠杆菌科的L-氨基酸生产细菌，其中细菌已被修饰以便不产生I型菌毛粘附素蛋白质在培养基中培养以产生并排出培养基中的所述L-氨基酸，并收集 所述L-氨基酸来自培养基。