公开(公告)号：US20150246938A1

公开(公告)日：2015-09-03

申请号：US14343992

申请日：2012-09-07

申请人： Akira Matsumura ,  Naotake Kobayashi ,  Yuji Nishiura ,  Sachie Tagashira ,  Shiro Kida ,  Kana Kurahashi ,  Mitsuhiro Yonehara

发明人： Akira Matsumura ,  Naotake Kobayashi ,  Yuji Nishiura ,  Sachie Tagashira ,  Shiro Kida ,  Kana Kurahashi ,  Mitsuhiro Yonehara

IPC分类号： C07F7/18 ,  C07D213/643 ,  C07D401/12 ,  C07D417/04 ,  C07D213/40 ,  C07D401/06 ,  C07D239/34 ,  C07D237/14 ,  C07D277/34 ,  C07D213/69

CPC分类号： C07F7/1804 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/4858 ,  C07C217/62 ,  C07C233/18 ,  C07C271/16 ,  C07C271/22 ,  C07C275/64 ,  C07D213/40 ,  C07D213/643 ,  C07D213/65 ,  C07D213/69 ,  C07D213/73 ,  C07D213/80 ,  C07D213/81 ,  C07D213/84 ,  C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/70 ,  C07D237/14 ,  C07D239/34 ,  C07D261/12 ,  C07D277/34 ,  C07D285/06 ,  C07D309/10 ,  C07D309/12 ,  C07D319/06 ,  C07D333/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07F7/0812

摘要： The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound.A compound of formula (I′): wherein R1 is substituted or unsubstituted aryl etc., R2 is each independently hydrogen, substituted or unsubstituted alkyl etc., R3 is each independently hydrogen, substituted or unsubstituted alkyl etc., n is an integer from 0 to 3, R12 is hydrogen, substituted or unsubstituted alkyl etc., Ring A is aromatic carbocycle or aromatic heterocycle, R9 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., m is an integer from 0 to 4, R4 and R5 is each independently hydrogen, substituted or unsubstituted alkyl etc., R6 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., R13 is hydrogen, substituted or unsubstituted alkyl etc., X5 is bond etc., R7 is hydrogen or substituted or unsubstituted alkyl, R8 is substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl etc.

摘要翻译： 本发明的目的是提供具有ACC2抑制活性的新化合物。 此外，本发明的目的是提供一种包含该化合物的药物组合物。 式（I'）的化合物：其中R 1为取代或未取代的芳基等，R 2各自独立地为氢，取代或未取代的烷基等，R 3各自独立地为氢，取代或未取代的烷基等，n为 0〜3，R 12为氢，取代或未取代的烷基等，环A为芳香族碳环或芳香族杂环，R9为取代或未取代的烷基，取代或未取代的链烯基等，m为0〜4的整数，R4和R5 各自独立地为氢，取代或未取代的烷基等，R 6为取代或未取代的烷基，取代或未取代的烯基等，R 13为氢，取代或未取代的烷基等，X 5为键等，R 7为氢或取代或未取代的 烷基，R8是取代或未取代的烷基羰基，取代或未取代的烯基羰基等