公开(公告)号：US20150246938A1

公开(公告)日：2015-09-03

申请号：US14343992

申请日：2012-09-07

申请人： Akira Matsumura ,  Naotake Kobayashi ,  Yuji Nishiura ,  Sachie Tagashira ,  Shiro Kida ,  Kana Kurahashi ,  Mitsuhiro Yonehara

发明人： Akira Matsumura ,  Naotake Kobayashi ,  Yuji Nishiura ,  Sachie Tagashira ,  Shiro Kida ,  Kana Kurahashi ,  Mitsuhiro Yonehara

IPC分类号： C07F7/18 ,  C07D213/643 ,  C07D401/12 ,  C07D417/04 ,  C07D213/40 ,  C07D401/06 ,  C07D239/34 ,  C07D237/14 ,  C07D277/34 ,  C07D213/69

CPC分类号： C07F7/1804 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/4858 ,  C07C217/62 ,  C07C233/18 ,  C07C271/16 ,  C07C271/22 ,  C07C275/64 ,  C07D213/40 ,  C07D213/643 ,  C07D213/65 ,  C07D213/69 ,  C07D213/73 ,  C07D213/80 ,  C07D213/81 ,  C07D213/84 ,  C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/70 ,  C07D237/14 ,  C07D239/34 ,  C07D261/12 ,  C07D277/34 ,  C07D285/06 ,  C07D309/10 ,  C07D309/12 ,  C07D319/06 ,  C07D333/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07F7/0812

摘要： The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound.A compound of formula (I′): wherein R1 is substituted or unsubstituted aryl etc., R2 is each independently hydrogen, substituted or unsubstituted alkyl etc., R3 is each independently hydrogen, substituted or unsubstituted alkyl etc., n is an integer from 0 to 3, R12 is hydrogen, substituted or unsubstituted alkyl etc., Ring A is aromatic carbocycle or aromatic heterocycle, R9 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., m is an integer from 0 to 4, R4 and R5 is each independently hydrogen, substituted or unsubstituted alkyl etc., R6 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., R13 is hydrogen, substituted or unsubstituted alkyl etc., X5 is bond etc., R7 is hydrogen or substituted or unsubstituted alkyl, R8 is substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl etc.

摘要翻译： 本发明的目的是提供具有ACC2抑制活性的新化合物。 此外，本发明的目的是提供一种包含该化合物的药物组合物。 式（I'）的化合物：其中R 1为取代或未取代的芳基等，R 2各自独立地为氢，取代或未取代的烷基等，R 3各自独立地为氢，取代或未取代的烷基等，n为 0〜3，R 12为氢，取代或未取代的烷基等，环A为芳香族碳环或芳香族杂环，R9为取代或未取代的烷基，取代或未取代的链烯基等，m为0〜4的整数，R4和R5 各自独立地为氢，取代或未取代的烷基等，R 6为取代或未取代的烷基，取代或未取代的烯基等，R 13为氢，取代或未取代的烷基等，X 5为键等，R 7为氢或取代或未取代的 烷基，R8是取代或未取代的烷基羰基，取代或未取代的烯基羰基等

公开(公告)号：US20100099676A1

公开(公告)日：2010-04-22

申请号：US12447743

申请日：2007-10-31

申请人： Takeshi Endoh ,  Yasuhiko Fujii ,  Eiichi Kojima ,  Genta Tadano ,  Naoko Yamaguchi ,  Yo Adachi ,  Sachie Tagashira ,  Yuki Tachibana ,  Naohiro Onodera

发明人： Takeshi Endoh ,  Yasuhiko Fujii ,  Eiichi Kojima ,  Genta Tadano ,  Naoko Yamaguchi ,  Yo Adachi ,  Sachie Tagashira ,  Yuki Tachibana ,  Naohiro Onodera

IPC分类号： A61K31/5377 ,  C07D417/10 ,  A61K31/497 ,  C07D413/14 ,  C07D401/02 ,  C07D413/02 ,  A61K31/4965 ,  C07D241/04

CPC分类号： C07D209/86 ,  C07D211/96 ,  C07D213/81 ,  C07D215/20 ,  C07D241/04 ,  C07D243/08 ,  C07D263/32 ,  C07D277/28 ,  C07D295/22 ,  C07D295/26 ,  C07D307/81 ,  C07D307/91

摘要： A compound represented by the general formula (I): wherein R1 is wherein R26 and R28 are each independently lower alkyloxy and the like; n1 is an integer of 0 to 3; Z is a optionally substituted C1-C5 alkynylene which may be interrupted with a substituent selected from Substituent group a and the like; A is a group represented by the formula: wherein R6 and R7 are each independently lower alkyl and the like; m and n are each independently 0, 1, or 2; R2 is a hydrogen atom and the like; R3 is optionally substituted lower alkyl and the like; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxyl and the like, or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 由通式（I）表示的化合物：其中R 1是其中R 26和R 28各自独立地为低级烷氧基等; n1为0〜3的整数， Z是可以被选自取代基组a等的取代基中断的任选取代的C 1 -C 5亚炔基; A是由下式表示的基团：其中R6和R7各自独立地为低级烷基等; m和n各自独立地为0,1或2; R2是氢原子等; R3是任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基等，或光学活性异构体，其药学上可接受的盐或溶剂化物。