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公开(公告)号：US20180187211A1
公开(公告)日：2018-07-05
申请号：US15542005
申请日：2016-01-07
IPC分类号： C12N15/86 , A61K39/00 , A61P35/00 , A61P35/04 , C12N7/00 , C07K14/705 , C07K14/47 , A61K45/06 , A61K39/395 , A61P31/20
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/575 , A61K2039/585 , A61K2039/70 , A61P31/20 , A61P35/00 , A61P35/04 , C07K14/4705 , C07K14/70596 , C07K16/2818 , C07K2317/76 , C12N7/00 , C12N2710/10023 , C12N2710/10043 , C12N2710/10071 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , A61K2300/00
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US11149087B2
公开(公告)日：2021-10-19
申请号：US15564413
申请日：2016-04-20
申请人： Etubics Corporation
IPC分类号： C12N15/86 , A61K39/395 , C07K16/28 , C07K16/08 , C07K16/30 , A61K39/29 , A61K39/00 , A61K31/282 , A61K31/513 , A61K31/519 , A61K38/17 , A61K39/12
摘要： Methods and compositions for generating immune responses using adenovirus vectors that allow multiple vaccinations or in combination with other therapy and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US11352642B2
公开(公告)日：2022-06-07
申请号：US15542005
申请日：2016-01-07
申请人： Etubics Corporation
IPC分类号： C12N15/63 , C12N15/86 , A61K39/00 , A61K39/235 , C07K16/28 , A61K39/12 , A61K39/395 , A61P31/20 , A61P35/04 , A61P35/00 , A61K45/06 , C07K14/47 , C07K14/705 , C12N7/00
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US11304998B2
公开(公告)日：2022-04-19
申请号：US17240285
申请日：2021-04-26
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
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公开(公告)号：US20210260175A1
公开(公告)日：2021-08-26
申请号：US17240285
申请日：2021-04-26
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
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公开(公告)号：US20190022209A1
公开(公告)日：2019-01-24
申请号：US16070104
申请日：2017-01-13
申请人： ETUBICS CORPORATION
IPC分类号： A61K39/145
摘要： Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.
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公开(公告)号：US20190030151A1
公开(公告)日：2019-01-31
申请号：US16070201
申请日：2017-01-13
申请人： ETUBICS CORPORATION
IPC分类号： A61K39/00 , C12N5/0783 , C07K16/30 , C07K14/705 , C07K14/725 , A61K45/06 , A61P35/00
摘要： Genetically modified compositions, such as adenoviral vectors and T cells, for treating diseases such as cancer and infectious diseases are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating diseases such as cancer and infectious diseases.
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公开(公告)号：US11104916B2
公开(公告)日：2021-08-31
申请号：US16317747
申请日：2017-07-14
申请人： ETUBICS CORPORATION
摘要： Compositions of a recombinant adenovirus based vector vaccine containing one or more alphavirus antigen genes are disclosed herein. Methods for constructing and producing such vaccines and methods of using these vaccines to generate broad based immune responses against alphaviruses are also described. Compositions described herein allow for vaccinations in individuals with preexisting immunity to adenovirus.
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公开(公告)号：US11020467B2
公开(公告)日：2021-06-01
申请号：US16614909
申请日：2018-05-25
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
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公开(公告)号：US11022406B2
公开(公告)日：2021-06-01
申请号：US16675981
申请日：2019-11-06
申请人： Adrian Rice
发明人： Adrian Rice
IPC分类号： F41H9/10
摘要： An defense substance spray canister is provided. The defense substance spray canister includes a cylindrical outer tube defining a longitudinal axis of the defense substance spray canister through an axial center of the cylindrical outer tube, a defense substance storage container contained within the cylindrical outer tube, the defense substance storage container including a valve operable to selectively release a flow of defense substance, an activation sleeve centered upon the longitudinal axis and, based upon relative movement of the activation sleeve relative to the cylindrical outer tube, operable to activate the valve, and a sleeve force transmission assembly operable to transform the relative movement of the activation sleeve relative to the cylindrical outer tube into an activation force upon the valve operable to selectively release the flow of defense substance.
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