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公开(公告)号：US20180187211A1
公开(公告)日：2018-07-05
申请号：US15542005
申请日：2016-01-07
IPC分类号： C12N15/86 , A61K39/00 , A61P35/00 , A61P35/04 , C12N7/00 , C07K14/705 , C07K14/47 , A61K45/06 , A61K39/395 , A61P31/20
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/575 , A61K2039/585 , A61K2039/70 , A61P31/20 , A61P35/00 , A61P35/04 , C07K14/4705 , C07K14/70596 , C07K16/2818 , C07K2317/76 , C12N7/00 , C12N2710/10023 , C12N2710/10043 , C12N2710/10071 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , A61K2300/00
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US09605276B2
公开(公告)日：2017-03-28
申请号：US14422504
申请日：2013-03-15
申请人： Frank R Jones , Elizabeth Gabitzsch
发明人： Frank R Jones , Elizabeth Gabitzsch
IPC分类号： A01N63/00 , C12N15/86 , C07K14/705 , A61K39/00 , C12N7/00
CPC分类号： C12N15/86 , A61K39/0011 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70503 , C07K14/70596 , C12N7/00 , C12N2710/10034 , C12N2710/10043 , C12N2710/10343 , C12N2799/022
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US20160076053A1
公开(公告)日：2016-03-17
申请号：US14422504
申请日：2013-03-15
IPC分类号： C12N15/86 , A61K39/00 , C07K14/705 , C12N7/00
CPC分类号： C12N15/86 , A61K39/0011 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70503 , C07K14/70596 , C12N7/00 , C12N2710/10034 , C12N2710/10043 , C12N2710/10343 , C12N2799/022
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
摘要翻译： 提供了使用允许使用相同腺病毒载体进行多次疫苗接种的腺病毒载体产生免疫反应的方法，并且在具有预先存在的腺病毒免疫的个体中接种疫苗。
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公开(公告)号：US11149087B2
公开(公告)日：2021-10-19
申请号：US15564413
申请日：2016-04-20
申请人： Etubics Corporation
IPC分类号： C12N15/86 , A61K39/395 , C07K16/28 , C07K16/08 , C07K16/30 , A61K39/29 , A61K39/00 , A61K31/282 , A61K31/513 , A61K31/519 , A61K38/17 , A61K39/12
摘要： Methods and compositions for generating immune responses using adenovirus vectors that allow multiple vaccinations or in combination with other therapy and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US11116827B2
公开(公告)日：2021-09-14
申请号：US16615925
申请日：2018-06-02
申请人： ETUBICS CORPORATION
摘要： In certain embodiments, methods and compositions are provided for generating immune responses against tumor antigens such as antigens or epitopes of HER1, HER2/neu, HER3, HER4, or any combination thereof. In particular embodiments, there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor antigens such as antigens or epitopes of HER1, HER2/neu, HER3, HER4, or any combination thereof, that allow for vaccinations in individuals with preexisting immunity to adenovirus.
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公开(公告)号：US11352642B2
公开(公告)日：2022-06-07
申请号：US15542005
申请日：2016-01-07
申请人： Etubics Corporation
IPC分类号： C12N15/63 , C12N15/86 , A61K39/00 , A61K39/235 , C07K16/28 , A61K39/12 , A61K39/395 , A61P31/20 , A61P35/04 , A61P35/00 , A61K45/06 , C07K14/47 , C07K14/705 , C12N7/00
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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公开(公告)号：US11304998B2
公开(公告)日：2022-04-19
申请号：US17240285
申请日：2021-04-26
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
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公开(公告)号：US20210260175A1
公开(公告)日：2021-08-26
申请号：US17240285
申请日：2021-04-26
申请人： ETUBICS CORPORATION
摘要： Methods and compositions for generating enhanced immune responses using adenovirus vectors that allow for multiple vaccinations in combination with an IL-15 superagonist complex in subjects in need thereof are provided.
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公开(公告)号：US20190022209A1
公开(公告)日：2019-01-24
申请号：US16070104
申请日：2017-01-13
申请人： ETUBICS CORPORATION
IPC分类号： A61K39/145
摘要： Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.
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10.发明授权公开(公告)号：US10695417B2
公开(公告)日：2020-06-30
申请号：US15542003
申请日：2016-01-07
申请人： Etubics Corporation
IPC分类号： A61K39/12 , A61K38/19 , C12N15/861 , A61K35/761
摘要： Methods for generating immune responses to Ebola virus antigens using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
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