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    SOLID-STATE SHEAR PULVERIZATION OF POLYMER MIXTURES
    1.
    发明申请
    SOLID-STATE SHEAR PULVERIZATION OF POLYMER MIXTURES 审中-公开
    聚合物混合物的固态剪切粉化

    公开(公告)号：US20160289434A1

    公开(公告)日：2016-10-06

    申请号：US15092124

    申请日：2016-04-06

    申请人： Zzyzx Polymers LLC

    发明人： Mark Tapsak ,  Philip Brunner

    IPC分类号： C08L23/06

    CPC分类号： C08L23/06 ,  C08J3/12 ,  C08J5/18 ,  C08J2323/06 ,  C08J2423/06 ,  C08L2205/025 ,  C08L2207/062 ,  C08L2207/068

    摘要： This disclosure describes a composition including an ultra-high molecular weight polymer and a low molecular weight polymer and having a bimodal molecular weight distribution and articles including the composition. This disclosure further describes methods including providing a mixture of an ultra-high molecular weight polymer and a low molecular weight polymer, and applying solid-state shear pulverization to the mixture to form a bimodal molecular weight alloy. This disclosure also describes methods that include providing a mixture including a first polymer and a second polymer, and applying solid-state shear pulverization to the mixture to disperse the first polymer in the second polymer.

    摘要翻译： 本公开内容描述了包含超高分子量聚合物和低分子量聚合物并具有双峰分子量分布的组合物和包含该组合物的制品。 本公开进一步描述了包括提供超高分子量聚合物和低分子量聚合物的混合物以及将固态剪切粉碎施加到混合物以形成双峰分子量合金的方法。 本公开还描述了包括提供包含第一聚合物和第二聚合物的混合物以及将固态剪切粉碎施加到混合物以将第一聚合物分散在第二聚合物中的方法。

    SYSTEMS AND METHODS OF REGULATING TEMPERATURE OF A SOLID-STATE SHEAR PULVERIZATION OR SOLID-STATE MELT EXTRUSION DEVICE
    4.
    发明申请
    SYSTEMS AND METHODS OF REGULATING TEMPERATURE OF A SOLID-STATE SHEAR PULVERIZATION OR SOLID-STATE MELT EXTRUSION DEVICE 审中-公开
    固态剪切或固态熔融挤出装置的温度调节系统和方法

    公开(公告)号：US20150131399A1

    公开(公告)日：2015-05-14

    申请号：US14537283

    申请日：2014-11-10

    申请人： Zzyzx Polymers LLC

    发明人： Philip BRUNNER ,  Mark TAPSAK

    IPC分类号： B29C47/60 ,  B29B7/82 ,  B29B7/46 ,  B29C47/84

    CPC分类号： B29C48/51 ,  B29B7/483 ,  B29B7/489 ,  B29B7/823 ,  B29C48/2564 ,  B29C48/402 ,  B29C48/509 ,  B29C48/625 ,  B29C48/82 ,  B29C48/845 ,  B29C48/85 ,  B29C48/92 ,  B29C2948/92704 ,  B29C2948/92876

    摘要： Systems and methods for controlling the temperature of a solid-state screw extruder may include providing an extrusion screw that incorporates one or more screw shaft channels. The shaft channels may be configured to conduct a flow of a heat conducting medium along a length of the shaft. The shaft channels may be incorporated into an exterior surface or within the body of the screw shaft. The extruder may include extrusion screw elements in mechanical communication with the shaft. Each of the elements may further include one or more element channels also configured to conduct a flow of the medium. The shaft channels and the element channels may be disposed to permit a flow of the medium therebetween. The temperature of the extrusion screws and/or screw elements may be controlled by circulating the medium from a source, through the shaft and element channels, and back to the source.

    摘要翻译： 用于控制固态螺杆挤出机的温度的系统和方法可以包括提供包括一个或多个螺杆轴通道的挤出螺杆。 轴通道可以被配置成沿着轴的长度传导导热介质的流动。 轴通道可以结合到螺钉轴的外表面或主体内。 挤出机可以包括与轴机械连通的挤压螺杆元件。 每个元件还可以包括一个或多个元件通道，该元件通道也被配置成进行介质的流动。 轴通道和元件通道可以被设置成允许介质之间的流动。 挤出螺钉和/或螺杆元件的温度可以通过使介质从源，通过轴和元件通道循环回到源来控制。

    DEVICES, COMPOSITIONS, AND METHODS FOR FABRICATING DRUG DELIVERY SYSTEMS
    6.
    发明申请
    DEVICES, COMPOSITIONS, AND METHODS FOR FABRICATING DRUG DELIVERY SYSTEMS 审中-公开
    用于制造药物递送系统的装置，组合物和方法

    公开(公告)号：US20150104508A1

    公开(公告)日：2015-04-16

    申请号：US14511688

    申请日：2014-10-10

    申请人： Zzyzx Polymers LLC

    发明人： Philip BRUNNER ,  Mark TAPSAK

    IPC分类号： A61J3/02 ,  A61K9/14

    CPC分类号： A61K9/146 ,  A61L15/22 ,  A61L15/44 ,  A61L17/005 ,  A61L27/14 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16 ,  B29C48/832 ,  B29C48/875

    摘要： Systems, methods, compositions, and devices related to the delivery of one or more biologically active agents to a body include the admixture of one or more biologically active agents with one or more biocompatible polymeric mixtures in a solid-state shear extrusion system. The extrusion systems may include one or more extrusion screws. One or more portions of the one or more extrusion screws, one or more extrusion system active elements, one or more barrel sections, and/or one or more extruder work zones may be temperature controlled to maintain a temperature of the biocompatible polymeric mixture in contact therewith at or below the liquefication temperature of the biocompatible polymeric materials. The resulting compositions from the extrusion systems may be fabricated into devices to deliver the one or more biologically active agents to a body.

    摘要翻译： 与一种或多种生物活性剂递送到身体有关的系统，方法，组合物和装置包括一种或多种生物活性剂与固态剪切挤出系统中的一种或多种生物相容性聚合物混合物的混合物。 挤出系统可以包括一个或多个挤出螺钉。 一个或多个挤出螺钉，一个或多个挤出系统活性元件，一个或多个筒部分和/或一个或多个挤出机工作区的一个或多个部分可以被温度控制以保持生物相容性聚合物混合物的温度接触 其中处于或低于生物相容性聚合物材料的液化温度。 来自挤出系统的所得组合物可以制造成将一种或多种生物活性剂递送到身体的装置。