公开(公告)号：US08273297B2

公开(公告)日：2012-09-25

申请号：US13279923

申请日：2011-10-24

申请人： Zhong Ding ,  Amy M. Wilson-Colley

发明人： Zhong Ding ,  Amy M. Wilson-Colley

IPC分类号： G01N21/00

CPC分类号： B01L3/0275 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2400/0409 ,  G01N33/5304 ,  G01N33/80 ,  Y10T436/25 ,  Y10T436/2575

摘要： An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays.

摘要翻译： 公开了一种用于在至少一个一次性探针尖端中进行颗粒凝集反应的装置和相关方法。 所述至少一个探针尖端包括用于样品采集的样品腔，用于通过离心或其它方法捕获颗粒的至少一个侧翼空腔，用于将样品与用于凝集的试剂混合的过渡区和用于光学的检测区 检测颗粒凝集。 可以将探针尖端附接有机构，以便通过探针尖端的内部容积控制流体的运动。 探针尖端对于高通量凝集型测定的自动化特别有用。

公开(公告)号：US20120040446A1

公开(公告)日：2012-02-16

申请号：US13279923

申请日：2011-10-24

申请人： Zhong Ding ,  Amy M. Wilson-Colley

发明人： Zhong Ding ,  Amy M. Wilson-Colley

IPC分类号： C12M1/34 ,  G01N33/536

CPC分类号： B01L3/0275 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2400/0409 ,  G01N33/5304 ,  G01N33/80 ,  Y10T436/25 ,  Y10T436/2575

摘要： An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays.

摘要翻译： 公开了一种用于在至少一个一次性探针尖端中进行颗粒凝集反应的装置和相关方法。 所述至少一个探针尖端包括用于样品采集的样品腔，用于通过离心或其它方法捕获颗粒的至少一个侧翼空腔，用于将样品与用于凝集的试剂混合的过渡区和用于光学的检测区 检测颗粒凝集。 可以将探针尖端附接机构，以便通过探针尖端的内部容积控制流体的运动。 探针尖端对于高通量凝集型测定的自动化特别有用。

公开(公告)号：US08048376B2

公开(公告)日：2011-11-01

申请号：US12953664

申请日：2010-11-24

申请人： Zhong Ding ,  Amy M. Wilson-Colley

发明人： Zhong Ding ,  Amy M. Wilson-Colley

IPC分类号： G01N21/00 ,  G01N31/00 ,  G01N33/00

CPC分类号： B01L3/0275 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2400/0409 ,  G01N33/5304 ,  G01N33/80 ,  Y10T436/25 ,  Y10T436/2575

摘要： An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays.

摘要翻译： 公开了一种用于在至少一个一次性探针尖端中进行颗粒凝集反应的装置和相关方法。 所述至少一个探针尖端包括用于样品采集的样品腔，用于通过离心或其它方法捕获颗粒的至少一个侧翼空腔，用于将样品与用于凝集的试剂混合的过渡区和用于光学的检测区 检测颗粒凝集。 可以将探针尖端附接机构，以便通过探针尖端的内部容积控制流体的运动。 探针尖端对于高通量凝集型测定的自动化特别有用。

公开(公告)号：US07792647B1

公开(公告)日：2010-09-07

申请号：US11484209

申请日：2006-07-11

申请人： Zhong Ding ,  Mark Sawczuk ,  Scott Steams ,  Muhidin Lelic

发明人： Zhong Ding ,  Mark Sawczuk ,  Scott Steams ,  Muhidin Lelic

IPC分类号： G01B5/28 ,  G01B5/30

CPC分类号： G01B13/00 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A method for quantitatively measuring error causing physical parameters in a fluid handling system, includes: measuring the pressure of air between a piston of a pump and a liquid being handled; detecting a pressure abnormality; determining the time at which the pressure abnormality begins to occur; and based on the time of the pressure abnormality determining the magnitude of the physical parameter causing the pressure abnormality. In a preferred embodiment, the error causing physical parameter is a bubble and the fluid handling is an aspirate operation in a diagnostic analyzer.

摘要翻译： 一种用于定量地测量在流体处理系统中产生物理参数的误差的方法，包括：测量泵的活塞和被处理的液体之间的空气压力; 检测压力异常; 确定压力异常开始发生的时间; 并且基于压力异常的时间来确定导致压力异常的物理参数的大小。 在优选实施例中，引起误差的物理参数是气泡，并且流体处理是诊断分析仪中的抽吸操作。

公开(公告)号：US07540200B2

公开(公告)日：2009-06-02

申请号：US10572050

申请日：2004-05-27

申请人： Tin-Woo Yung ,  Scott T. Slocum ,  Robert E. Sandstrom ,  Zhong Ding ,  Leif Smitt

发明人： Tin-Woo Yung ,  Scott T. Slocum ,  Robert E. Sandstrom ,  Zhong Ding ,  Leif Smitt

IPC分类号： G01N3/00

CPC分类号： G01M10/00

摘要： This invention relates generally to testing apparatus and methodology for measuring fluid dynamic properties of structures within fluid flows. One embodiment includes a fluid induced motion testing apparatus of the type which includes a test rig suitable for holding a test body in a fluid body. The apparatus may include any of an actuator suitable for producing a force upon the test body; a turbulence generator located in the fluid body up current from the test body suitable for generating a turbulent flow field with uniform turbulence intensity across the fluid body-test body interface, the turbulent flow field including dominate vortical structures, the axis of the vortical structures about parallel to the longitudinal axis of the test body; or a test body adjuster suitable for adjusting the test body relative to the fluid current in four or more increments, thereby enabling multiple headings of the test body to be tested against the current of the fluid body. This invention also relates to designing and constructing offshore structures and to producing hydrocarbon resources using offshore structures designed using the testing apparatus and methodology.

摘要翻译： 本发明一般涉及用于测量流体流体内结构的流体动力特性的测试装置和方法。 一个实施例包括一种类型的流体感应运动测试装置，其包括适于将测试体保持在流体体内的测试台。 该装置可以包括适于在测试体上产生力的致动器中的任何一个; 位于流体中的湍流发生器，其来自测试体的上流，其适于产生跨越流体体 - 测试体界面的均匀湍流强度的湍流流场，湍流场包括主旋涡结构，涡旋结构的轴线约为 平行于测试体的纵向轴线; 或测试体调节器，其适于以四个或更多个增量相对于流体流量调节测试体，从而能够针对流体体的电流来测试测试体的多个标题。 本发明还涉及使用测试装置和方法设计的使用海上结构设计和构造海上结构和生产碳氢化合物资源。

公开(公告)号：US07335382B1

公开(公告)日：2008-02-26

申请号：US11066802

申请日：2005-02-25

申请人： Xian-Zhong Ding ,  Thomas E. Adrian ,  Peter D. Collin

发明人： Xian-Zhong Ding ,  Thomas E. Adrian ,  Peter D. Collin

IPC分类号： A61K35/36 ,  A61K35/12

CPC分类号： A61K35/616

摘要： The present invention relates to new classes of anti-cancer agents. In particular, the present invention provides materials derived from natural sources as anti-cancer agents, alone, or in combination with other anti-cancer agents or therapies.

摘要翻译： 本发明涉及新类型的抗癌剂。 特别地，本发明提供源自天然来源的作为抗癌剂的材料，单独或与其它抗癌剂或疗法组合。

公开(公告)号：US20060149111A1

公开(公告)日：2006-07-06

申请号：US11368662

申请日：2006-03-06

申请人： Cor Van Egmond ,  Zhong Ding

发明人： Cor Van Egmond ,  Zhong Ding

IPC分类号： B01J19/00 ,  B01J8/18

CPC分类号： C07C1/20 ,  C07C2529/83 ,  C07C2529/85 ,  C10G3/49 ,  C10G3/62 ,  C10G2400/20 ,  Y02P30/20 ,  Y02P30/42 ,  Y02P30/48 ,  C07C11/02

摘要： A process is provided for converting oxygenate to olefins from a fluidized bed reactor which comprises removal of catalyst fines from a quenched vaporous effluent by contacting with a liquid low in catalyst fines content, e.g., oxygenate feedstock, or by-product water from the oxygenates to olefins conversion which is stripped and/or filtered. The process typically comprises: contacting a feedstock comprising oxygenate with a catalyst comprising a molecular sieve under conditions effective to produce a deactivated catalyst having carbonaceous deposits and a product comprising the olefins; separating the deactivated catalyst from the product to provide a separated vaporous product which contains catalyst fines; quenching the separated vaporous product with a liquid medium containing water and catalyst fines, in an amount sufficient for forming a light product fraction comprising light olefins and catalyst fines and a heavy product fraction comprising water, heavier hydrocarbons and catalyst fines; treating the light product fraction by contacting with a liquid substantially free of catalyst fines to provide a light product fraction having reduced catalyst fines content and a liquid fraction of increased fines content; compressing the light product fraction having reduced catalyst fines content; and recovering the light olefins from the compressed light product fraction.

公开(公告)号：US06606213B1

公开(公告)日：2003-08-12

申请号：US09332351

申请日：1999-06-11

申请人： Kian Keong Ooi ,  Jack Ming Teng ,  Soon Wah Leow ,  Ming Zhong Ding

发明人： Kian Keong Ooi ,  Jack Ming Teng ,  Soon Wah Leow ,  Ming Zhong Ding

IPC分类号： G11B2102

CPC分类号： G11B5/59633

摘要： A disc drive system and method of screening an actuator resonance includes a servo controller providing a multi-servo zone architecture. The servo controller partitions the disc into a plurality of servo zones. Each of the servo zones has a corresponding servo gain. When an actuator resonance is detected in one of the servo zones, the servo controller reduces the corresponding servo gain of the detected servo zone such that a drive with very low resonance at a certain zone does not affect the servo bandwidth of the other good zones. Accordingly, a drive with very low resonance is prevented from being scrapped. Further, the screening technique allows a drive to have an adequate servo margin for its normal operation after going through a resonance detection test.

摘要翻译： 盘驱动系统和筛选致动器谐振的方法包括提供多伺服区结构的伺服控制器。 伺服控制器将盘划分成多个伺服区。 每个伺服区具有相应的伺服增益。 当在其中一个伺服区域中检测到致动器谐振时，伺服控制器减小检测到的伺服区域的相应伺服增益，使得在某一区域具有非常低的共振的驱动器不影响其它良好区域的伺服带宽。 因此，防止具有非常低谐振的驱动器被报废。 此外，筛选技术允许驱动器在进行共振检测测试之后具有用于其正常操作的足够的伺服余量。

公开(公告)号：US06597528B1

公开(公告)日：2003-07-22

申请号：US09558265

申请日：2000-04-25

申请人： Louis Seng Hong Pang ,  Kian Keong Ooi ,  Jack Ming Teng ,  Ming Zhong Ding

发明人： Louis Seng Hong Pang ,  Kian Keong Ooi ,  Jack Ming Teng ,  Ming Zhong Ding

IPC分类号： G11B5596

CPC分类号： G11B5/5556

摘要： A disc drive includes a base and a disc rotatably attached to the base. The disc drive also includes an actuator assembly rotatably attached to said base and a device for moving the actuator assembly. The actuator assembly includes a transducer head in a transducing relationship with respect to the disc. The disc drive includes a disc drive controller for controlling movement of the actuator during track follow and track seek operations. The disc drive controller monitors the actuator during seek operations. The disc drive controller further computes a maximum average settle time from the monitored settle times. The dis drive controller further compares the maximum average settle time to a predetermined threshold value, and issues a command signal to adjust seek profile parameters of the disc drive to eliminate resonance in the actuator arm during a seek operation.

摘要翻译： 盘驱动器包括基座和可旋转地附接到基座的盘。 盘驱动器还包括可旋转地附接到所述基座的致动器组件和用于移动致动器组件的装置。 致动器组件包括相对于盘的换能关系的换能器头。 磁盘驱动器包括一个磁盘驱动器控制器，用于在轨道跟踪跟踪寻道操作期间控制致动器的运动。 磁盘驱动器控制器在寻道操作期间监视执行器。 磁盘驱动器控制器还从监视的安置时间计算最大平均安置时间。 驱动控制器进一步将最大平均安定时间与预定阈值进行比较，并且发出命令信号以调整盘驱动器的寻找轮廓参数，以消除在寻道操作期间致动器臂中的共振。

公开(公告)号：US20110252872A1

公开(公告)日：2011-10-20

申请号：US12759809

申请日：2010-04-14

申请人： Zhong Ding

发明人： Zhong Ding

IPC分类号： G01N11/08

CPC分类号： G01N11/08 ,  G01N35/1009

摘要： A method for estimating the viscosity of a liquid in an aspirating or dispensing probe, includes: measuring a reference pressure which is the pressure inside a metering tip when no dispense or aspirate is occurring (Pref); dispensing or aspirating a liquid having a volume of air between the liquid and the pumping mechanism of the probe; stopping the aspirate or dispense; measuring the pressure (Pstop′) inside the tip at a time (t) which is the time when the aspirate or dispense is stopped; measuring the pressure (Pstop′) inside the tip at a time (t′) after t; and estimating viscosity as a function of Pref, Pstop, and Pstop′. In a preferred embodiment, the method is carried out on a diagnostic analyzer.

摘要翻译： 一种用于估计吸入或分配探针中的液体的粘度的方法，包括：测量当不发生分配或吸出时计量尖端内的压力的参考压力（Pref）; 在液体和探针的泵送机构之间分配或吸入具有空气体积的液体; 停止抽吸或分配; 在抽吸或分配停止的时间（t）测量尖端内的压力（Pstop'）; 在t之后的时间（t'）测量尖端内的压力（Pstop'）; 并估计作为Pref，Pstop和Pstop'的函数的粘度。 在优选实施例中，该方法在诊断分析器上进行。