公开(公告)号：US20090275978A1

公开(公告)日：2009-11-05

申请号：US12498278

申请日：2009-07-06

申请人： Zia Yassinzadeh

发明人： Zia Yassinzadeh

IPC分类号： A61B17/08

CPC分类号： A61B17/0057

摘要： The present invention advantageously provides self-tensioning occlusion devices, systems, and methods for percutaneous access and closure of vascular puncture sites. One device comprises a catheter body having a proximal end and a distal end, an occlusion member, and a tensioning member. The occlusion member, such an expansible member, is disposed on a distal end of the body. The tensioning member, such as a spring or coil, is slidably disposed over the body and proximal the expansion member. Generally, during application, the tensioning member will be positionable against subcutaneous tissue so as to lodge and anchor the expansible member against the puncture site. In particular, the expansible member allows for sealing of the puncture site while the tensioning member applies and maintains tension to the expansible occluder so that it is seated against the puncture site at a vascular surface.

摘要翻译： 本发明有利地提供了用于经皮通路和闭合血管穿刺部位的自张紧闭塞装置，系统和方法。 一个装置包括具有近端和远端的导管主体，闭塞构件和张紧构件。 这种可膨胀构件的遮挡构件设置在主体的远端上。 张紧构件，例如弹簧或线圈，可滑动地设置在身体上并且靠近扩张构件。 通常，在施用期间，张紧构件将可抵靠皮下组织定位，以便将可膨胀构件保持并固定在穿刺部位上。 特别地，可膨胀构件允许在张紧构件施加并且保持对可膨胀封堵器的张力的同时密封穿刺部位，使得其在血管表面处抵靠穿刺部位。

公开(公告)号：US07344533B2

公开(公告)日：2008-03-18

申请号：US10260187

申请日：2002-09-28

申请人： Robert M. Pearson ,  Steven A. Daniel ,  Daniel J. Balbierz ,  Theodore C. Johnson ,  Zia Yassinzadeh

发明人： Robert M. Pearson ,  Steven A. Daniel ,  Daniel J. Balbierz ,  Theodore C. Johnson ,  Zia Yassinzadeh

IPC分类号： A61B18/18

CPC分类号： A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00196 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00738 ,  A61B2018/00744 ,  A61B2018/0075 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2218/002

摘要： A method and apparatus for carrying our thermal ablation of target tissue is disclosed. The apparatus includes an RF ablation device having a multi-electrode electrode assembly designed to be deployed in target tissue, defining a selected-volume tissue region to be ablated, and having infusion channels for infusing a liquid into the target tissue during the ablation process. A control unit in the apparatus is operably connected to an RF energy source, for controlling the RF power level supplied to the electrodes, and to an infusion device, for controlling the rate of infusion of a liquid through the device into the tissue. During both electrode deployment and tissue ablation, impedance and or temperature measurements made within the tissue are used to control the RF source and infusion device, for optimizing the time and extent of tissue ablation.

摘要翻译： 公开了一种用于携带我们的靶组织热消融的方法和装置。 该装置包括RF消融装置，其具有设计成部署在靶组织中的多电极电极组件，限定要消融的选择体积的组织区域，并且具有用于在消融过程期间将液体注入靶组织的输注通道。 装置中的控制单元可操作地连接到RF能量源，用于控制提供给电极的RF功率水平，以及用于控制通过装置将液体输入到组织中的输注装置。 在电极部署和组织消融期间，组织内进行的阻抗和/或温度测量用于控制RF源和输注装置，以优化组织消融的时间和程度。

公开(公告)号：US20070276435A1

公开(公告)日：2007-11-29

申请号：US11772718

申请日：2007-07-02

申请人： Zia Yassinzadeh ,  Jeffrey Weitz ,  Alan Stafford

发明人： Zia Yassinzadeh ,  Jeffrey Weitz ,  Alan Stafford

IPC分类号： A61B17/03

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00659 ,  A61B2017/00676 ,  A61B2017/00778 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/3484 ,  A61B2090/032

摘要： Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with chemical and/or biological agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A chemical and/or biological sealing member disposed proximal the expansible member is then displaced so as to expose a chemical and/or biological region or release region of the device. At least one chemical and/or biological agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.

摘要翻译： 描述了药物洗脱血管闭合装置和用于闭合设置在组织管的远端处的血管穿刺部位的方法。 装置和方法依赖于身体自身机制的组合，以实现与化学和/或生物剂的止血以加速止血过程。 一种方法包括以下步骤：通过组织管道引入闭合装置，并在血管内的装置的远端部署可膨胀构件以封闭穿刺部位。 设置在可膨胀构件附近的化学和/或生物密封构件然后被移位，以暴露设备的化学和/或生物区域或释放区域。 此后，至少一种化学和/或生物剂从该装置中释放并进入组织道，以加速该道中的闭塞过程。

公开(公告)号：US6103196A

公开(公告)日：2000-08-15

申请号：US53195

申请日：1998-04-01

申请人： Zia Yassinzadeh ,  Paul J. Lingane

发明人： Zia Yassinzadeh ,  Paul J. Lingane

IPC分类号： G01N11/04 ,  G01N33/49 ,  G01N35/00 ,  G01N33/86 ,  G01N21/03

CPC分类号： G01N11/04 ,  G01N33/4905 ,  G01N2035/00425 ,  Y10T436/117497 ,  Y10T436/25 ,  Y10T436/25625

摘要： Fluid sample tester assembly (12) comprises a cartridge (6) having a pressure chamber (22) and entrance port (20) connected by a passageway (24). An analyte reagent (36) is positioned along the fluid passageway so that when a liquid sample (28) is drawn through the entrance port into the passageway, the analyte reagent mixes with the sample. The sample is preferably drawn into the cartridge by temporarily reducing the volume of the pressure chamber, applying the sample to the entrance port and then returning the pressure chamber to its initial volume; this can also be done by heating the chamber, contacting the sample and then cooling the chamber. The end of the sample defines a boundary surface (30) along the fluid passageway. Positive and negative pressure is applied to the sample to cause the boundary surface to oscillate within the passageway. The position of the boundary surface is continuously monitored so that continuous boundary position data is obtained and is analyzed to obtain a flow-related characteristic, typically speed of coagulation, of the sample.

摘要翻译： 流体样品测试器组件（12）包括具有通过通道（24）连接的压力室（22）和入口（20）的盒（6）。 分析物试剂（36）沿着流体通道定位，使得当液体样品（28）通过入口进入通道时，分析物试剂与样品混合。 样品优选通过临时减小压力室的体积，将样品施加到入口端口，然后使压力室返回到其初始体积而被吸入筒中; 这也可以通过加热室，接触样品然后冷却室完成。 样品的末端限定沿着流体通道的边界表面（30）。 对样品施加正压和负压，使得边界面在通道内振荡。 连续监测边界面的位置，以获得连续的边界位置数据并进行分析，以获得样品的流动相关特性，即凝固速度。

公开(公告)号：US20140142547A1

公开(公告)日：2014-05-22

申请号：US13868775

申请日：2013-04-23

申请人： Zia Yassinzadeh

发明人： Zia Yassinzadeh

IPC分类号： A61B17/00 ,  A61M5/168

CPC分类号： A61B17/0057 ,  A61B2017/00557 ,  A61B2017/0061 ,  A61B2017/00623 ,  A61B2017/00637 ,  A61B2017/00676 ,  A61M5/16881

摘要： The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body.

摘要翻译： 本发明有利地提供了用于经皮通路和闭合血管穿刺部位的装置，系统和方法。 在一个实施例中，用于增强体腔或管道中穿刺部位止血的装置包括具有一个管状构件的导管，所述管状构件具有近端和远端，所述远端具有在导管管状件的至少纵向部分之间延伸的一个内腔 会员。 一个管状构件包括每个具有近端和远端的外部和内部管状体。 外部和内部管状体中的至少一个可相对于另一个纵向移动。 具有近端和远端的可膨胀构件设置在一个管状构件的远端上。 可膨胀构件的远端连接到内管体的远端，其近端连接到外管体的远端。

公开(公告)号：US08323305B2

公开(公告)日：2012-12-04

申请号：US10718504

申请日：2003-11-19

申请人： Gordon H. Epstein ,  Todd E. Lempert ,  Brian B. Martin ,  David M. Taylor ,  Richard M. Romley ,  Zia Yassinzadeh ,  Glenn Foy

发明人： Gordon H. Epstein ,  Todd E. Lempert ,  Brian B. Martin ,  David M. Taylor ,  Richard M. Romley ,  Zia Yassinzadeh ,  Glenn Foy

IPC分类号： A61M29/00

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12099 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00495 ,  A61B2017/00641

摘要： A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

摘要翻译： 一种用于在血管内扩张的装置，其具有在体内限定内腔的壁。 该装置包括具有近端和远端并具有纵向轴线的细长管状构件。 膨胀构件由细长管状构件的远端承载并且可在收缩和膨胀构型之间移动。 具有近端和远端外表面的可变形膜至少部分地覆盖处于膨胀构型的膨胀构件。 当膨胀构件处于膨胀构型时，近端和远端外表面具有基本上不同的构造。 展开装置由细长管状构件的近端承载，并且联接到膨胀构件，用于在收缩和膨胀构型之间移动膨胀构件。 手柄组件由细长管状构件的近端承载并联接到所述展开装置。

公开(公告)号：US20100168767A1

公开(公告)日：2010-07-01

申请号：US12492779

申请日：2009-06-26

申请人： Zia Yassinzadeh ,  Delfin Pelayo

发明人： Zia Yassinzadeh ,  Delfin Pelayo

IPC分类号： A61B17/10 ,  A61B17/08

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00623 ,  A61B2017/00654 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/22067 ,  A61B2090/3966

摘要： Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.

摘要翻译： 用于密封设置在组织管道末端处的血管壁穿透物的装置包括轴，闭塞元件，止血植入物和保护套管。 该装置通过组织道展开，闭塞元件暂时阻塞血管壁穿透并阻止其通过其反渗透。 通常是可生物降解的聚合物（例如携带抗增殖剂或凝​​血促进剂的胶原）的止血植入物将从密封装置展开并留在原位以增强血管壁穿透的封闭，同时具有最小的瘢痕形成。 植入物可以是不透射线的，以便在释放之前观察。

公开(公告)号：US20080154303A1

公开(公告)日：2008-06-26

申请号：US11614276

申请日：2006-12-21

申请人： Zia Yassinzadeh

发明人： Zia Yassinzadeh

IPC分类号： A61B17/03

CPC分类号： A61B17/0057 ,  A61B2017/00557 ,  A61B2017/0061 ,  A61B2017/00623 ,  A61B2017/00637 ,  A61B2017/00676 ,  A61M5/16881

摘要： The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body.

摘要翻译： 本发明有利地提供了用于经皮通路和闭合血管穿刺部位的装置，系统和方法。 在一个实施例中，用于增强体腔或管道中穿刺部位止血的装置包括具有一个管状构件的导管，所述管状构件具有近端和远端，所述远端具有在导管管状件的至少纵向部分之间延伸的一个内腔 会员。 一个管状构件包括每个具有近端和远端的外部和内部管状体。 外部和内部管状体中的至少一个可相对于另一个纵向移动。 具有近端和远端的可膨胀构件设置在一个管状构件的远端上。 可膨胀构件的远端连接到内管体的远端，其近端连接到外管体的远端。

公开(公告)号：US20050267522A1

公开(公告)日：2005-12-01

申请号：US10974008

申请日：2004-10-25

申请人： Zia Yassinzadeh ,  Delfin Pelayo

发明人： Zia Yassinzadeh ,  Delfin Pelayo

IPC分类号： A61B17/00 ,  A61B17/08 ,  A61F2/958

CPC分类号： A61B17/0057 ,  A61B2017/00659 ,  A61B2017/00986 ,  A61B2090/0807

摘要： The present invention advantageously provides self-tensioning occlusion devices, systems, and methods for percutaneous access and closure of vascular puncture sites. One device comprises a catheter body, an occlusion member, and a tensioning member. The occlusion member, such an expansible member, is disposed on a distal end of the body. The tensioning member, such as a spring or coil, is slidably disposed over the body and proximal the expansion member. Generally, during application, the tensioning member will be deployed against subcutaneous tissue so as to apply tension to the expansible member against the puncture site. The substantial hold once the tension is applied is then provided by external means, such as an anchoring clip.

摘要翻译： 本发明有利地提供了用于经皮通路和闭合血管穿刺部位的自张紧闭塞装置，系统和方法。 一个装置包括导管主体，遮挡构件和张紧构件。 这种可膨胀构件的遮挡构件设置在主体的远端上。 张紧构件，例如弹簧或线圈，可滑动地设置在身体上并且靠近扩张构件。 通常，在施用期间，张紧构件将被展开抵靠皮下组织，以便可靠地抵靠穿刺部位向可膨胀构件施加张力。 一旦施加张力，实质上的保持力然后由外部装置（例如锚固夹）提供。

公开(公告)号：US20050228443A1

公开(公告)日：2005-10-13

申请号：US10821633

申请日：2004-04-09

申请人： Zia Yassinzadeh

发明人： Zia Yassinzadeh

IPC分类号： A61B17/00 ,  A61B17/08 ,  A61B17/22

CPC分类号： A61B17/0057 ,  A61B2017/00654 ,  A61B2017/00672 ,  A61B2017/22065

摘要： The present invention provides devices, systems, and methods for percutaneously sealing a puncture site in tissue tracts and vessels in human or animal bodies. One system includes a locating assembly that is used to locate the puncture site and can also provide temporary hemostasis when the system is used for closing a vessel puncture. The system also includes a compression assembly comprising a tubular member with a balloon on a distal end thereof. This balloon is at a fixed distance from the locator tip which locates the balloon outside the vessel wall at a predetermined distance. Inflation of this balloon causes forward elongation of the balloon which compresses subcutaneous tissue between the distal tip of the balloon and the vessel wall. This tissue compression against the puncture site is the mechanism that provides hemostasis.

摘要翻译： 本发明提供了用于经皮密封人或动物体内的组织束和血管中的穿刺部位的装置，系统和方法。 一个系统包括用于定位穿刺部位的定位组件，并且当系统用于关闭血管穿刺时也可提供临时止血。 该系统还包括压缩组件，其包括在其远端上具有气囊的管状构件。 该气球距离定位器尖端固定的距离，定位器尖端将气囊定位在血管壁外部预定距离处。 该气囊的充气引起气囊的向前伸长，其压缩气囊的远端和容器壁之间的皮下组织。 针对穿刺部位的这种组织压缩是提供止血的机制。