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公开(公告)号：US10910209B2
公开(公告)日：2021-02-02
申请号：US16812883
申请日：2020-03-09
申请人： bioMérieux, Inc.
发明人： James VanGordon , Bradford Clay
摘要： MALDI-TOF MS systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the MS by a user. The (successive) different delay times can change by 1 ns to about 500 ns, and can be in a range that is between 1-2500 nanoseconds.
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2.发明申请MALDI-TOF MASS SPECTROMETERS WITH DELAY TIME VARIATIONS AND RELATED METHODS 有权具有延迟时间变化的MALDI-TOF质谱仪和相关方法公开(公告)号：US20160064202A1
公开(公告)日：2016-03-03
申请号：US14837832
申请日：2015-08-27
申请人： bioMérieux, Inc.
发明人： James VanGordon , Bradford Clay
CPC分类号： H01J49/40 , H01J49/0027 , H01J49/0418 , H01J49/164 , H01J49/403
摘要： MALDI-TOF MS systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the MS by a user. The (successive) different delay times can change by 1 ns to about 500 ns, and can be in a range that is between 1-2500 nanoseconds.
摘要翻译： MALDI-TOF MS系统具有固态激光器以及电离和加速之间的连续和变化的延迟时间（例如提取），以在单个采样信号采集期间改变聚焦质量，而不需要用户调整MS。 （连续）不同的延迟时间可以改变1ns至约500ns，并且可以在1-2500纳秒之间的范围内。
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公开(公告)号：US11104931B2
公开(公告)日：2021-08-31
申请号：US16014665
申请日：2018-06-21
申请人： bioMérieux, Inc.
发明人： Ronnie J. Robinson , Mark Joseph Fanning , Stanley Michael Philipak , Richard Scott Remes , James Clement Bishop , Gary W. Sommer , Lawrence E Guerra , Michael A Herron
摘要： A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
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公开(公告)号：US10395357B2
公开(公告)日：2019-08-27
申请号：US15606157
申请日：2017-05-26
申请人： bioMérieux, Inc.
发明人： Thierry Vivet , Dennis Connor , Mark Segrist , Mark S. Wilson , John G. Link
摘要： The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.
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公开(公告)号：US10068760B2
公开(公告)日：2018-09-04
申请号：US15362979
申请日：2016-11-29
申请人： bioMérieux, Inc.
发明人： James VanGordon , Bradford Clay
摘要： MALDI-TOF MS systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the MS by a user. The (successive) different delay times can change by 1 ns to about 500 ns, and can be in a range that is between 1-2500 nanoseconds.
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公开(公告)号：US10450144B2
公开(公告)日：2019-10-22
申请号：US15606115
申请日：2017-05-26
申请人： bioMérieux, Inc.
发明人： Thierry Vivet , Michael Belgeri , Walter Clynes
摘要： The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
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公开(公告)号：US20170341873A1
公开(公告)日：2017-11-30
申请号：US15606115
申请日：2017-05-26
申请人： bioMérieux, Inc.
发明人： Thierry Vivet , Michael Belgeri , Walter Clynes
摘要： The present invention is directed to a system and method for transferring specimen containers between detection instruments. The method may include transporting a specimen container in a locator well to a container transfer station in a first automated detection apparatus; sensing the specimen container at the container transfer station using a first sensor; transferring the specimen container from the container transfer station of the first automated microbial detection apparatus to an automated loading mechanism of a second automated microbial detection apparatus; detecting that the specimen container is positioned over the automated loading mechanism of the second automated microbial detection apparatus using a second sensor; and releasing the specimen container onto the automated loading mechanism of the second automated microbial detection apparatus.
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公开(公告)号：US11625025B2
公开(公告)日：2023-04-11
申请号：US15606133
申请日：2017-05-26
申请人： bioMérieux, Inc.
发明人： Thierry Vivet , Warren Vincent
IPC分类号： G01N35/00 , G05B19/418 , G01N35/02 , G01N35/04
摘要： The present invention is directed to a system and method for load balancing specimen containers between a plurality of automated detection apparatuses. The method may include receiving a specimen container at a container pick-up station in a first automated detection apparatus; determining loading ability, transfer status, and cell availability of the first automated detection apparatus and one or more downstream automated detection apparatuses; and transferring the specimen container from the first automated detection apparatus to a downstream automated detection apparatus when a first ratio of effective available cell count to effective capacity in the first automated detection apparatus is less than a second ratio of total effective available cell count to total effective capacity of a sum of the first automated detection apparatus and the one or more downstream automated detection apparatuses.
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公开(公告)号：US11334980B2
公开(公告)日：2022-05-17
申请号：US16549360
申请日：2019-08-23
申请人： bioMérieux, Inc.
发明人： Thierry Vivet , Dennis Connor , Mark Segrist , Mark S. Wilson , John G. Link
摘要： The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.
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公开(公告)号：US20180298418A1
公开(公告)日：2018-10-18
申请号：US16014665
申请日：2018-06-21
申请人： bioMérieux, Inc.
发明人： Ronnie J. Robinson , Mark Joseph Fanning , Stanley Michael Philipak , Richard Scott Remes , James Clement Bishop , Gary W. Sommer , Lawrence E. Guerra , Michael A. Herron
摘要： A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
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