公开(公告)号：US10688126B2

公开(公告)日：2020-06-23

申请号：US15374942

申请日：2016-12-09

申请人： nanoComposix, Inc. ,  Sebacia, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： C08K3/00 ,  A61K33/38 ,  A61K9/51 ,  A61L27/00 ,  B22F1/00 ,  B22F1/02 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  A61K47/24 ,  A61K47/32 ,  C08J3/205 ,  C08K3/08

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

公开(公告)号：US12029831B2

公开(公告)日：2024-07-09

申请号：US18089047

申请日：2022-12-27

申请人： CORONADO AESTHETICS, LLC ,  nanoComposix, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： C09D129/04 ,  A61K9/51 ,  A61K33/38 ,  A61K47/24 ,  A61K47/32 ,  A61L27/00 ,  B22F1/054 ,  B22F1/0545 ,  B22F1/14 ,  B22F1/145 ,  B22F1/16 ,  C08J3/205 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C09D125/06 ,  C09D139/06 ,  B22F1/068

CPC分类号： A61L27/00 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5138 ,  A61K33/38 ,  A61K47/24 ,  A61K47/32 ,  B22F1/0545 ,  B22F1/0551 ,  B22F1/14 ,  B22F1/145 ,  B22F1/147 ,  B22F1/16 ,  C08J3/2053 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06 ,  A61L2300/104 ,  B22F1/068 ,  B22F2301/255 ,  B22F2998/10 ,  C08J2325/18 ,  C08J2329/04 ,  C08K2003/0806

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

公开(公告)号：US09249334B2

公开(公告)日：2016-02-02

申请号：US14048996

申请日：2013-10-08

申请人： nanoComposix, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba

IPC分类号： C09D139/06 ,  A61K9/51 ,  A61K33/38 ,  A61L27/00 ,  B22F1/00 ,  C09D125/06 ,  C09D129/04 ,  B22F1/02

CPC分类号： A61K33/38 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5138 ,  A61K47/24 ,  A61K47/32 ,  A61L27/00 ,  A61L2300/104 ,  B22F1/0022 ,  B22F1/0055 ,  B22F1/0081 ,  B22F1/0088 ,  B22F1/02 ,  B22F2001/0033 ,  B22F2001/0092 ,  B22F2301/255 ,  B22F2998/10 ,  C08J3/2053 ,  C08J2325/18 ,  C08J2329/04 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C08K2003/0806 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoplates, such as silver nanoplates or silver platelet nanoparticles, and to nanoparticles, solutions and substrates prepared by said methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

摘要翻译： 本发明的实施方案涉及用于制备纳米板的高光密度溶液的方法，例如银纳米板或银片晶纳米颗粒，以及通过所述方法制备的纳米颗粒，溶液和底物。 该方法可以包括在浓缩之前，期间和/或之后稳定纳米颗粒的稳定剂（例如，与纳米颗粒表面结合或以其他方式连接的化学或生物制剂），从而允许生产稳定的高光学 银纳米片的密度溶液。 该方法还可以包括增加溶液中银纳米板的浓度，从而提高溶液光密度。

公开(公告)号：US09675953B2

公开(公告)日：2017-06-13

申请号：US15027426

申请日：2014-10-09

申请人： nanoComposix, Inc.

发明人： Steven J. Oldenburg ,  Richard K. Baldwin

IPC分类号： B01J13/20 ,  C01B33/113 ,  B22F9/16 ,  A61K9/51 ,  C01B33/18 ,  B01J13/18 ,  C09B67/02 ,  C01B33/26 ,  B22F1/00 ,  B22F1/02 ,  G01N33/543 ,  C09B67/08

CPC分类号： B01J13/20 ,  A61K9/5115 ,  B01J13/18 ,  B22F1/0018 ,  B22F1/0025 ,  B22F1/0062 ,  B22F1/02 ,  B22F9/16 ,  B22F2001/0033 ,  B22F2001/0037 ,  B22F2009/165 ,  B22F2301/255 ,  B22F2302/45 ,  C01B33/113 ,  C01B33/18 ,  C01B33/26 ,  C09B67/0007 ,  C09B67/0097 ,  G01N33/54346

摘要： The disclosed technology relates generally to material systems which include a plurality of particles and methods of making the same. The particles have a core and a shell which encapsulates the core and has at least one atomic element not included in the core. The cores of the particles have a median maximum dimension that is less than 10 microns and a median of at least one axial dimension that is between 10 nm and 500 nm. The shells of the particles have a median thickness that is less than 100 nm, a silicon concentration that is between 10% and 50% on the basis of the weight of the shells, and an aluminum concentration that is between 0.01% and 5% on the basis of the weight of the shells.

公开(公告)号：US20170087183A1

公开(公告)日：2017-03-30

申请号：US15374942

申请日：2016-12-09

申请人： nanoComposix, Inc. ,  Sienna Biopharmaceuticals, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： A61K33/38 ,  B22F1/02 ,  C08K3/08 ,  B22F1/00 ,  A61K9/51 ,  C08J3/205

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

公开(公告)号：US20160075851A1

公开(公告)日：2016-03-17

申请号：US14947508

申请日：2015-11-20

申请人： nanoComposix, Inc. ,  Sienna Labs, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： C08K3/28 ,  C08K3/38 ,  C08K5/1535 ,  C08K3/36 ,  C08K5/092

CPC分类号： A61K33/38 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5138 ,  A61K47/24 ,  A61K47/32 ,  A61L27/00 ,  A61L2300/104 ,  B22F1/0022 ,  B22F1/0055 ,  B22F1/0081 ,  B22F1/0088 ,  B22F1/02 ,  B22F2001/0033 ,  B22F2001/0092 ,  B22F2301/255 ,  B22F2998/10 ,  C08J3/2053 ,  C08J2325/18 ,  C08J2329/04 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C08K2003/0806 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

公开(公告)号：US09212294B2

公开(公告)日：2015-12-15

申请号：US14681379

申请日：2015-04-08

申请人： nanoComposix, Inc. ,  Sienna Labs, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： C09D139/06 ,  A61K9/51 ,  A61K33/38 ,  A61L27/00 ,  C09D125/06 ,  C09D129/04 ,  B22F1/00 ,  B22F1/02

CPC分类号： A61K33/38 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5138 ,  A61K47/24 ,  A61K47/32 ,  A61L27/00 ,  A61L2300/104 ,  B22F1/0022 ,  B22F1/0055 ,  B22F1/0081 ,  B22F1/0088 ,  B22F1/02 ,  B22F2001/0033 ,  B22F2001/0092 ,  B22F2301/255 ,  B22F2998/10 ,  C08J3/2053 ,  C08J2325/18 ,  C08J2329/04 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C08K2003/0806 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

摘要翻译： 本发明的实施方案涉及制备纳米颗粒的高光密度溶液的方法，例如纳米板，银纳米板或银片晶纳米颗粒，以及通过该方法制备的溶液和底物。 该方法可以包括在浓缩之前，期间和/或之后稳定纳米颗粒的稳定剂（例如，与纳米颗粒表面结合或以其他方式连接的化学或生物制剂），从而允许生产稳定的高光学 银纳米片的密度溶液。 该方法还可以包括增加溶液中银纳米板的浓度，从而提高溶液光密度。

公开(公告)号：US20150225599A1

公开(公告)日：2015-08-13

申请号：US14681379

申请日：2015-04-08

申请人： nanoComposix, Inc. ,  Sienna Labs, Inc.

发明人： Steven J. Oldenburg ,  Martin G. Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： C09D139/06 ,  C09D125/06 ,  C09D129/04

CPC分类号： A61K33/38 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5138 ,  A61K47/24 ,  A61K47/32 ,  A61L27/00 ,  A61L2300/104 ,  B22F1/0022 ,  B22F1/0055 ,  B22F1/0081 ,  B22F1/0088 ,  B22F1/02 ,  B22F2001/0033 ,  B22F2001/0092 ,  B22F2301/255 ,  B22F2998/10 ,  C08J3/2053 ,  C08J2325/18 ,  C08J2329/04 ,  C08K3/08 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  C08K2003/0806 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

摘要翻译： 本发明的实施方案涉及制备纳米颗粒的高光密度溶液的方法，例如纳米板，银纳米板或银片晶纳米颗粒，以及通过该方法制备的溶液和底物。 该方法可以包括在浓缩之前，期间和/或之后稳定纳米颗粒的稳定剂（例如，与纳米颗粒表面结合或以其他方式连接的化学或生物制剂），从而允许生产稳定的高光学 银纳米片的密度溶液。 该方法还可以包括增加溶液中银纳米板的浓度，从而提高溶液光密度。

公开(公告)号：US20230139868A1

公开(公告)日：2023-05-04

申请号：US18089047

申请日：2022-12-27

申请人： CORONADO AESTHETICS, LLC ,  nanoComposix, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： A61K33/38 ,  A61K9/51 ,  A61L27/00 ,  B22F1/14 ,  B22F1/16 ,  B22F1/145 ,  B22F1/0545 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  A61K47/24 ,  A61K47/32 ,  C08J3/205 ,  C08K3/08

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

公开(公告)号：US11583553B2

公开(公告)日：2023-02-21

申请号：US16902455

申请日：2020-06-16

申请人： nanoComposix, Inc. ,  Sebacia, Inc.

发明人： Steven J. Oldenburg ,  Martin Miranda ,  David S. Sebba ,  Todd J. Harris

IPC分类号： B22F1/14 ,  A61K33/38 ,  A61K9/51 ,  A61L27/00 ,  B22F1/16 ,  B22F1/145 ,  B22F1/0545 ,  C09D125/06 ,  C09D129/04 ,  C09D139/06 ,  C08K3/28 ,  C08K3/36 ,  C08K3/38 ,  C08K5/092 ,  C08K5/1535 ,  A61K47/24 ,  A61K47/32 ,  C08J3/205 ,  C08K3/08 ,  B22F1/068 ,  B22F1/054

摘要： Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.